{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T05:50:01Z","timestamp":1793771401122,"version":"4.6.1"},"reference-count":30,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ActaO"],"abstract":"<jats:p>Background and purpose: The aim of this study was to identify the prevalence of modifiable risk factors of surgical site infections (SSI) in patients undergoing primary elective total joint arthroplasty (TJA) receiving conventional preoperative preparation, and to explore their association with infectious outcomes.Patients and methods:\u00a0Information regarding modifiable risk factors (anemia, diabetes, obesity, nutritional status, smoking, physical activity) was prospectively gathered in patients undergoing primary TJA of hip or knee in 2018\u20132020 at a single institution with 6 weeks\u2019 follow-up time.Results: 738 patients (median age 68 years [IQR 61\u201373], women 57%) underwent TJA (knee 64%, hip 36%). Anemia was detected in 8%, diabetes was present in 9%, an additional 2% had undiagnosed diabetes (HbA1c &gt; 47 mmol\/mol), and 8% dysglycemia (HbA1c 42\u201347 mmol\/mol). Obesity (BMI \u2265 30) was observed in 52%. Serum albumin, total lymphocyte count, and vitamin D below normal limits was identified in 0.1%, 18%, and 16%, respectively. Current smokers were 7%. Surgical site complications occurred in 116 (16%), superficial SSI in 57 (8%), progressing to periprosthetic joint infection in 7 cases. Univariate analysis identified higher odds of superficial SSI for BMI \u2265 30 (OR 2.1, 95%CI 1.2\u20133.8) and HbA1c \u2265 42 mmol\/mol (OR 2.2, CI 1.1\u20134.2), but no association was found with other factors.Conclusion: In a general population undergoing primary TJA an association was found between obesity (52%) and dysglycemia\/diabetes (19%) and superficial SSI (8%), which progressed to PJI in 12% of cases, generating a 1% total rate of PJI. Modification of these risk factors might mitigate infectious adverse outcomes.<\/jats:p>","DOI":"10.2340\/17453674.2023.8480","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T07:44:24Z","timestamp":1675323864000},"page":"38-44","source":"Crossref","is-referenced-by-count":16,"title":["Prevalence of modifiable risk factors in primary elective arthroplasty and their association with infections"],"prefix":"10.2340","volume":"94","author":[{"given":"Maria","family":"Sigurdardottir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin Ingi","family":"Sigurdsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yngvi","family":"Olafsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solveig H","family":"Sverrisdottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingibjorg","family":"Gunnarsdottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil L","family":"Sigurdsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigurbergur","family":"Karason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2023,2,2]]},"reference":[{"key":"27737","doi-asserted-by":"crossref","unstructured":"Eriksson H K, Lazarinis S. Patient-related factors associated with superficial surgical site infection and progression to a periprosthetic joint infection after elective primary total joint arthroplasty: a single-centre, retrospective study in Sweden. BMJ Open 2022; 12: e060754. doi: 10.1136\/bmjopen-2022-060754.","DOI":"10.1136\/bmjopen-2022-060754"},{"key":"27738","doi-asserted-by":"crossref","unstructured":"Gallo J, Nieslanikova E. Prevention of prosthetic joint infection: from traditional approaches towards quality improvement and data mining. J Clin Med 2020; 9. doi: 10.3390\/jcm9072190.","DOI":"10.3390\/jcm9072190"},{"key":"27739","unstructured":"Eka A, Chen A F. Patient-related medical risk factors for periprosthetic joint infection of the hip and knee. Ann Transl Med 2015; 3: 233. doi: 10.3978\/j.issn.2305-5839.2015.09.26."},{"key":"27740","doi-asserted-by":"crossref","unstructured":"Wan S, Sparring V, Cabrales D A, Jansson K, Wikman A. Clinical and budget impact of treating preoperative anemia in major orthopedic surgery: a retrospective observational study. J Arthroplasty 2020; 35: 3084-8. doi: 10.1016\/j.arth.2020.06.018.","DOI":"10.1016\/j.arth.2020.06.018"},{"key":"27741","doi-asserted-by":"crossref","unstructured":"Shohat N, Muhsen K, Gilat R, Rondon A J, Chen AF, Parvizi J. Inadequate glycemic control is associated with increased surgical site infection in total joint arthroplasty: a systematic review and meta-analysis. J Arthroplasty 2018; 33: 2312-21.e2313. doi: 10.1016\/j.arth.2018.02.020.","DOI":"10.1016\/j.arth.2018.02.020"},{"key":"27742","doi-asserted-by":"crossref","unstructured":"Citak M, Toussaint B, Abdelaziz H, Klebig F, Dobinsky A, Gebauer M, et al. Elevated HbA1c is not a risk factor for wound complications following total joint arthroplasty: a prospective study. 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