{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T19:39:06Z","timestamp":1787859546491,"version":"build-2784847793"},"reference-count":31,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ActaO"],"abstract":"<jats:p>Background and purpose: Bilateral femoral distraction osteogenesis in patients with achondroplasia is insufficiently reported. We aimed to perform the first study that exclusively analyzed simultaneous bilateral femoral distraction osteogenesis with motorized intramedullary lengthening nails via an antegrade approach in patients with achondroplasia focused on reliability, accuracy, precision, and the evolving complications.Patients and methods: In this retrospective singlecenter study we analyzed patients with achondroplasia who underwent simultaneous bilateral femoral lengthening with antegrade intramedullary lengthening nails between October 2014 and April 2019. 15 patients (30 femoral segments) of median age 14 years (interquartile range [IQR] 12\u201315) were available for analysis. The median follow-up was 29 months (IQR 27\u201337) after nail implantation. Results: The median distraction length per segment was 49 mm (IQR 47\u201351) with a median distraction index of 1.0 mm\/day (IQR 0.9\u20131.0), and a median consolidation index of 20 days\/cm (IQR 17\u201323). Reliability of the lengthening nails was 97% and their calculated accuracy and precision were 96% and 95%, respectively. The most common complication was temporary restriction of knee range of motion during distraction in 10 of 30 of the lengthened segments. 1 patient was treated with 2 unplanned additional surgeries due to premature consolidation.Conclusion: The method is reliable and accurate with few complications.<\/jats:p>","DOI":"10.2340\/17453674.2024.35226","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T03:15:11Z","timestamp":1706584511000},"page":"47-54","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of simultaneous bilateral femoral distraction osteogenesis with antegrade intramedullary lengthening nails in achondroplasia with rhizomelic short stature: a retrospective study of 15 patients with a minimum follow-up of 2 years"],"prefix":"10.2340","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8781-2751","authenticated-orcid":false,"given":"Bj\u00f6rn","family":"Vogt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5658-2298","authenticated-orcid":false,"given":"Andrea","family":"Laufer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Gosheger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Toporowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Antfang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7934-2983","authenticated-orcid":false,"given":"Jan Duedal","family":"R\u00f6lfing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1731-6293","authenticated-orcid":false,"given":"Robert","family":"R\u00f6dl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Frommer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2024,1,30]]},"reference":[{"key":"47646","doi-asserted-by":"crossref","unstructured":"Foreman P K, van Kessel F, van Hoorn R, van den Bosch J, Shediac R, Landis S. Birth prevalence of achondroplasia: a systematic literature review and meta-analysis. Am J Med Genet A 2020; 182: 2297-316. doi: 10.1002\/ajmg.a.61787.","DOI":"10.1002\/ajmg.a.61787"},{"key":"47647","doi-asserted-by":"crossref","unstructured":"Coi A, Santoro M, Garne E, Pierini A, Addor M C, Alessandri J L, et al. Epidemiology of achondroplasia: a population-based study in Europe. Am J Med Genet A 2019; 179: 1791-8. doi: 10.1002\/ajmg.a.61289.","DOI":"10.1002\/ajmg.a.61289"},{"key":"47648","doi-asserted-by":"crossref","unstructured":"Lavini F, Renzi-Brivio L, de Bastiani G. Psychologic, vascular, and physiologic aspects of lower limb lengthening in achondroplastics. Clin Orthop Relat Res 1990: 138-42.","DOI":"10.1097\/00003086-199001000-00016"},{"key":"47649","doi-asserted-by":"crossref","unstructured":"Kim S J, Balce G C, Agashe M V, Song S H, Song H R. Is bilateral lower limb lengthening appropriate for achondroplasia?: midterm analysis of the complications and quality of life. 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Simultaneous bilateral femoral and tibial lengthening in achondroplasia. Children (Basel) 2021; 8. doi: 10.3390\/children8090749.","DOI":"10.3390\/children8090749"},{"key":"47656","doi-asserted-by":"crossref","unstructured":"Hafez M, Nicolaou N, Offiah A, Giles S N, Madan S S, Fernandes J A. Femoral lengthening in children: a comparison between magnetic intramedullary lengthening nails and external fixators. J Pediatr Orthop 2021; 10.1097\/BPO.0000000000002039. doi: 10.1097\/BPO.0000000000002039.","DOI":"10.1097\/BPO.0000000000002039"},{"key":"47657","doi-asserted-by":"crossref","unstructured":"Calder P R, McKay J E, Timms A J, Roskrow T, Fugazzotto S, Edel P, et al. Femoral lengthening using the Precice intramedullary limblengthening system: outcome comparison following antegrade and retrograde nails. 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[Application of motorized intramedullary lengthening nails in skeletally immature patients: undications and limitations]. Unfallchirurg 2018; 121: 860-7. doi: 10.1007\/s00113-018-0541-4.","DOI":"10.1007\/s00113-018-0541-4"},{"key":"47661","doi-asserted-by":"crossref","unstructured":"Radler C, Mindler G T, Stauffer A, Weiss C, Ganger R. Limb lengthening with Precice intramedullary lengthening nails in children and adolescents. J Pediatr Orthop 2022; 42: e192-e200. doi: 10.1097\/BPO.0000000000002016.","DOI":"10.1097\/BPO.0000000000002016"},{"key":"47662","doi-asserted-by":"crossref","unstructured":"Iliadis A D, Palloni V, Wright J, Goodier D, Calder P. Pediatric lower limb lengthening using the PRECICE nail: our experience with 50 cases. J Pediatr Orthop 2021; 41: e44-e49. doi: 10.1097\/BPO.0000000000001672.","DOI":"10.1097\/BPO.0000000000001672"},{"key":"47663","doi-asserted-by":"crossref","unstructured":"Frommer A, Roedl R, Gosheger G, Niemann M, Turkowski D, Toporowski G, et al. 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Lengthening with monolateral external fixation versus magnetically motorized intramedullary nail in congenital femoral deficiency. J Pediatr Orthop 2019; 39: 458-65. doi: 10.1097\/BPO.0000000000001047.","DOI":"10.1097\/BPO.0000000000001047"},{"key":"47669","doi-asserted-by":"crossref","unstructured":"Frommer A, Roedl R, Gosheger G, Hasselmann J, Fuest C, Toporowski G, et al. Focal osteolysis and corrosion at the junction of Precice Stryde intramedullary lengthening device: preliminary clinical, radiological, and metallurgic analysis of 57 lengthened segments. Bone Joint Res 2021; 10: 425-36. doi: 10.1302\/2046-3758.107.BJR-2021-0146.R1.","DOI":"10.1302\/2046-3758.107.BJR-2021-0146.R1"},{"key":"47670","doi-asserted-by":"crossref","unstructured":"Masci G, Palmacci O, Vitiello R, Bonfiglio N, Bocchi MB, Cipolloni V, et al. Limb lengthening with PRECICE magnetic nail in pediatric patients: a systematic review. 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