{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:23:05Z","timestamp":1787062985071,"version":"build-2736575974"},"reference-count":27,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ActaO"],"abstract":"<jats:p>Background and purpose:\u00a0Awareness of socioeconomic disparities in outcomes following surgical procedures is increasing. This highlights a critical challenge for clinical practice and public health. We examined whether low socioeconomic position (SEP) was associated with the incidence of revisions due to periprosthetic joint infection (PJI) following total knee arthroplasty (TKA).Methods:\u00a0This cohort study included 75,141 patients undergoing TKA (2010\u20132021), identified from the Danish Knee Arthroplasty Registry (DKR). Individual-level SEP information, including wealth, living arrangements, and education, was obtained from Danish social and administrative registries. Revisions due to PJI were identified using a method combining the DKR and microbiology data. We calculated the cumulative incidence of revision due to PJI at 90 days and 2 years, and 2-year hazard ratios (aHRs) of revision due to PJI for lower vs. higher SEP groups, adjusted for age, sex, weight, and Charlson Comorbidity Index scores, with 95% confidence intervals (CI).Results:\u00a0The incidence of revision due to PJI after 2 years of follow-up was 1.5% (CI 1.3\u20131.6) for low-wealth patients vs. 1.2% (CI 1.1\u20131.3) for high-wealth patients (aHR 1.3, CI 1.1\u20131.5); 1.5% (CI 1.3\u20131.7) for patients living alone vs. 1.2% (CI 1.1\u20131.3) for those cohabiting (aHR 1.4, CI 1.2\u20131.6); and 1.3% (CI 1.1\u20131.4) for patients with low education vs. 1.2% (CI 1.0\u20131.4) for those with high education (aHR 1.0, CI 0.8\u20131.2).Conclusion:\u00a0Revision due to PJI among low-wealth patients and those living alone versus the corresponding high-SEP group were associated with increased risk of revision due to PJI.<\/jats:p>","DOI":"10.2340\/17453674.2025.43678","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T08:33:03Z","timestamp":1747643583000},"source":"Crossref","is-referenced-by-count":4,"title":["Association of socioeconomic inequality and risk of periprosthetic joint infection after total knee arthroplasty: a Danish cohort study of 75,141 cases"],"prefix":"10.2340","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2566-8093","authenticated-orcid":false,"given":"Marie","family":"Anneberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0132-8182","authenticated-orcid":false,"given":"Anders","family":"Troelsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3688-6865","authenticated-orcid":false,"given":"Per","family":"Gundtoft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3288-9401","authenticated-orcid":false,"given":"Alma B","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"112066","doi-asserted-by":"crossref","unstructured":"Lum Z C, Natsuhara K M, Shelton T J, Giordani M, Pereira G C, Meehan J P. Mortality during total knee periprosthetic joint infection. J Arthroplasty 2018; 33(12): 3783-8. doi: 10.1016\/j.arth.2018.08.021.","DOI":"10.1016\/j.arth.2018.08.021"},{"key":"112067","doi-asserted-by":"crossref","unstructured":"Boddapati V, Fu M C, Mayman D J, Su E P, Sculco P K, McLawhorn A S. Revision total knee arthroplasty for periprosthetic joint infection is associated with increased postoperative morbidity and mortality relative to noninfectious revisions. J Arthroplasty 2018; 33: 521-6. doi: 10.1016\/j.arth.2017.09.021.","DOI":"10.1016\/j.arth.2017.09.021"},{"key":"112068","doi-asserted-by":"crossref","unstructured":"Galobardes B. Indicators of socioeconomic position (part 1). J Epidemiol Community Health 2006; 60: 7-12. doi: 10.1136\/jech.2004.023531.","DOI":"10.1136\/jech.2004.023531"},{"key":"112069","doi-asserted-by":"crossref","unstructured":"Lenguerrand E, Whitehouse M R, Beswick A D, Kunutsor S K, Foguet P, Porter M, et al. Risk factors associated with revision for prosthetic joint infection following knee replacement: an observational cohort study from England and Wales. Lancet Infect Dis 2019; 19: 589-600. doi: 10.1016\/s1473-3099(18)30755-2.","DOI":"10.1016\/S1473-3099(18)30755-2"},{"key":"112070","doi-asserted-by":"crossref","unstructured":"Anneberg M, Troelsen A, Gundtoft P, S\u00f8rensen H T, Pedersen A B. Temporal trends in revision rate due to knee periprosthetic joint infection: a study of 115,120 cases from the Danish Knee Arthroplasty Register. Acta Orthop 2023; 94: 616-24. doi: 10.2340\/17453674.2023.33294.","DOI":"10.2340\/17453674.2023.33294"},{"key":"112071","doi-asserted-by":"crossref","unstructured":"MAC. McMaster Arthroplasty Collaborative: Incidence and predictors of prosthetic joint infection following primary total knee arthroplasty: a 15-year population-based cohort study. J Arthroplasty 2022; 37: 367-72 e361. doi: 10.1016\/j.arth.2021.10.006.","DOI":"10.1016\/j.arth.2021.10.006"},{"key":"112072","doi-asserted-by":"crossref","unstructured":"Mackenbach J P. Health inequalities: persistence and change in European welfare states. Oxford: Oxford University Press; 2019.","DOI":"10.1093\/oso\/9780198831419.001.0001"},{"key":"112073","doi-asserted-by":"crossref","unstructured":"Dekeyser G J, Anderson M B, Meeks H D, Pelt C E, Peters C L, Gililland J M. Socioeconomic status may not be a risk factor for periprosthetic joint infection. J Arthroplasty 2020; 35: 1900-5. doi: 10.1016\/j.arth.2020.02.058.","DOI":"10.1016\/j.arth.2020.02.058"},{"key":"112074","doi-asserted-by":"crossref","unstructured":"Kamath C C, O\u2019Byrne T J, Lewallen D G, Berry D J, Maradit Kremers H. Neighborhood-level socioeconomic deprivation, rurality, and long-term outcomes of patients undergoing total joint arthroplasty: analysis from a large, tertiary care hospital. Mayo Clin Proc Innov Qual Outcomes 2022; 6: 337-46. doi: 10.1016\/j.mayocpiqo.2022.06.001.","DOI":"10.1016\/j.mayocpiqo.2022.06.001"},{"key":"112075","doi-asserted-by":"crossref","unstructured":"Edwards N M, Varnum C, Nelissen R G H H, Overgaard S, Pedersen A B. The association between socioeconomic status and the 30- and 90-day risk of infection after total hip arthroplasty. Bone Joint J 2022; 104-B: 221-6. doi: 10.1302\/0301-620x.104b2.bjj-2021-1030.r1.","DOI":"10.1302\/0301-620X.104B2.BJJ-2021-1030.R1"},{"key":"112076","doi-asserted-by":"crossref","unstructured":"Barrack R L, Ruh E L, Chen J, Lombardi A V, Berend K R, Parvizi J, et al. Impact of socioeconomic factors on outcome of total knee arthroplasty. Clin Orthop Relat Res 2014; 472: 86-97. doi: 10.1007\/s11999-013-3002-y.","DOI":"10.1007\/s11999-013-3002-y"},{"key":"112077","doi-asserted-by":"crossref","unstructured":"Schmidt M, Schmidt S A J, Adelborg K, Sundboll J, Laugesen K, Ehrenstein V, et al. 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Enhancing the data capture of periprosthetic joint infections in the Danish Knee Arthroplasty Registry: validity assessment and incidence estimation. Acta Orthop 2024; 95: 166-73. doi: 10.2340\/17453674.2024.40358.","DOI":"10.2340\/17453674.2024.40358"},{"key":"112084","doi-asserted-by":"crossref","unstructured":"Klen\u00f8 A N, Stisen M B, Edwards N M, Mechlenburg I, Pedersen A B. Socioeconomic status and use of analgesic drugs before and after primary hip arthroplasty: a population-based cohort study of 103,209 patients during 1996\u20132018. Acta Orthop 2022; 93: 171-8. doi: 10.2340\/17453674.2021.955.","DOI":"10.2340\/17453674.2021.955"},{"key":"112085","doi-asserted-by":"crossref","unstructured":"Edwards N M, Varnum C, Overgaard S, Pedersen A B. Impact of socioeconomic status on the 90- and 365-day rate of revision and mortality after primary total hip arthroplasty: a cohort study based on 103,901 patients with osteoarthritis from national databases in Denmark. 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