{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:07:42Z","timestamp":1790075262320,"version":"4.0.1"},"reference-count":25,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ActaO"],"abstract":"<jats:p>Background and purpose:\u00a0Although hip dysplasia is a risk factor for osteoarthritis (OA), its natural progression in adults remains poorly understood. In a longitudinal observational study, we aimed to estimate differences in OA incidence, time to OA, and minimum joint space width (JSW) between dysplastic hips and contralateral non-dysplastic hips.Methods:\u00a0Adults aged 20\u201370 years who underwent pelvic radiographs in Malm\u00f6, Sweden, during 2007\u20132008 were included. Inclusion criteria were unilateral hip dysplasia (lateral center edge angle \u2264 20\u00b0), no OA at baseline, and available follow-up imaging of both hips. OA incidence was assessed using last available follow-up imaging, whereas minimum JSW was measured bilaterally on the last available radiograph of native hips.Results:\u00a050 participants (median age 47 years, IQR 39\u201362, 36 women) were included, with median follow-up 12.5 years (IQR 7.8\u201314.7). OA developed in 19\/50 dysplastic hips and 16\/50 non-dysplastic hips, corresponding to a paired risk difference of 6 percentage points (95% confidence interval [CI] \u20137 to 20). Mean time to OA was 8.2 years (SD 5.2) for dysplastic hips and 9.6 years (SD 5.1) for non-dysplastic hips (mean difference \u20131.2 years, CI \u20134.8 to 2.4). Minimum JSW at follow-up was 3.3 mm (SD 1.3) in dysplastic hips and 3.5 mm (SD 0.9) in non-dysplastic hips (mean difference \u20130.2 mm, CI \u2013 0.6 to 0.2).Conclusion:\u00a0No clear differences were observed in OA incidence, time to OA, or minimum JSW between dysplastic and contralateral non-dysplastic hips.<\/jats:p>","DOI":"10.2340\/17453674.2026.46828","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:53:42Z","timestamp":1790074422000},"source":"Crossref","is-referenced-by-count":0,"title":["Development of osteoarthritis in adults with untreated hip dysplasia: a longitudinal observational study"],"prefix":"10.2340","volume":"97","author":[{"given":"Rebecka","family":"Vinge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6556-4320","authenticated-orcid":false,"given":"Cecilia","family":"Rogmark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8194-2432","authenticated-orcid":false,"given":"Daniel","family":"Wenger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6829-4787","authenticated-orcid":false,"given":"S\u00f8ren","family":"Overgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7717-1578","authenticated-orcid":false,"given":"Carl Johan","family":"Tiderius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"168906","doi-asserted-by":"crossref","unstructured":"Turkiewicz A, Petersson I F, Bj\u00f6rk J, Hawker G, Dahlberg L E, Lohmander L S, et al. Current and future impact of osteoarthritis on health care: a population-based study with projections to year 2032. Osteoarthritis Cartilage 2014; 22(11): 1826-32. doi: 10.1016\/j.joca.2014.07.015.","DOI":"10.1016\/j.joca.2014.07.015"},{"key":"168907","doi-asserted-by":"crossref","unstructured":"Hunter D J, Bierma-Zeinstra S. Osteoarthritis. Lancet 2019; 393(10182): 1745-59. doi: 10.1016\/s0140-6736(19)30417-9.","DOI":"10.1016\/S0140-6736(19)30417-9"},{"key":"168908","unstructured":"Wiberg G. Studies on dysplastic acetabula and congenital subluxation of the hip: with special reference to the complication of osteoarthritis. Acta Chir Scand 1939; 83(58): 5-135."},{"key":"168909","doi-asserted-by":"crossref","unstructured":"Lee C B, Mata-Fink A, Millis M B, Kim Y J. Demographic differences in adolescent-diagnosed and adult-diagnosed acetabular dysplasia compared with infantile developmental dysplasia of the hip. J Pediatr Orthop 2013; 33(2): 107-11. doi: 10.1097\/BPO.0b013e3182745456.","DOI":"10.1097\/BPO.0b013e3182745456"},{"key":"168910","doi-asserted-by":"crossref","unstructured":"Leide R, Bohman A, Wenger D, Overgaard S, Tiderius C J, Rogmark C. Hip dysplasia is not uncommon but frequently overlooked: a cross-sectional study based on radiographic examination of 1,870 adults. Acta Orthop 2021; 92(5): 575-80. doi: 10.1080\/17453674.2021.1936918.","DOI":"10.1080\/17453674.2021.1936918"},{"key":"168911","unstructured":"O\u2019Connor K P, Marshall B J, Davison J, Clohisy J C, Willey M C. Prevalence of radiographic hip dysplasia in the general adult population: a systematic review. Iowa Orthop J 2024; 44(1): 145-9. PMID: 38919354."},{"key":"168912","doi-asserted-by":"crossref","unstructured":"Riedstra N S, Boel F, van Buuren M M A, Ahedi H, Arbabi V, Arden N, et al. Acetabular dysplasia and the risk of developing hip osteoarthritis within 4-8 years: an individual participant data meta-analysis of 18,807 hips from the World COACH consortium. Osteoarthritis Cartilage 2025; 33(3): 373-82. doi: 10.1016\/j.joca.2024.12.001.","DOI":"10.1016\/j.joca.2024.12.001"},{"key":"168913","doi-asserted-by":"crossref","unstructured":"Vinge R, Riedstra N, Tiderius C J, Bierma-Zeinstra S, Agricola R, Runhaar J. Hip dysplasia as risk factor for clinically relevant and radiographic hip osteoarthritis: 10-year results from the CHECK cohort. Rheumatology (Oxford) 2025; 64(1): 149-55. doi: 10.1093\/rheumatology\/kead650.","DOI":"10.1093\/rheumatology\/kead650"},{"key":"168914","doi-asserted-by":"crossref","unstructured":"Saberi Hosnijeh F, Zuiderwijk M E, Versteeg M, Smeele H T, Hofman A, Uitterlinden A G, et al. Cam deformity and acetabular dysplasia as risk factors for hip osteoarthritis. Arthritis Rheumatol 2017; 69(1): 86-93. doi: 10.1002\/art.39929.","DOI":"10.1002\/art.39929"},{"key":"168915","doi-asserted-by":"crossref","unstructured":"Riedstra N S, Vinge R, Herfkens J, Eygendaal D, Bierma-Zeinstra S M A, Runhaar J, et al. Acetabular dysplasia and the risk of developing hip osteoarthritis at 2,5,8, and 10 years follow-up in a prospective nationwide cohort study (CHECK). Semin Arthritis Rheum 2023; 60: 152194. doi: 10.1016\/j.semarthrit.2023.152194.","DOI":"10.1016\/j.semarthrit.2023.152194"},{"key":"168916","doi-asserted-by":"crossref","unstructured":"Cooperman D R, Wallensten R, Stulberg S D. Acetabular dysplasia in the adult. Clin Orthop Relat Res 1983; (175): 79-85. PMID: 6839611.","DOI":"10.1097\/00003086-198305000-00013"},{"key":"168917","doi-asserted-by":"crossref","unstructured":"Hasegawa Y, Iwata H, Mizuno M, Genda E, Sato S, Miura T. The natural course of osteoarthritis of the hip due to subluxation or acetabular dysplasia. Arch Orthop Trauma Surg 1992; 111(4): 187-91. doi: 10.1007\/bf00571474.","DOI":"10.1007\/BF00571474"},{"key":"168918","doi-asserted-by":"crossref","unstructured":"Murphy S B, Ganz R, M\u00fcller M E. The prognosis in untreated dysplasia of the hip: a study of radiographic factors that predict the outcome. J Bone Joint Surg Am 1995; 77(7): 985-9. doi: 10.2106\/00004623-199507000-00002.","DOI":"10.2106\/00004623-199507000-00002"},{"key":"168919","doi-asserted-by":"crossref","unstructured":"Jacobsen S, Sonne-Holm S, S\u00f8balle K, Gebuhr P, Lund B. Joint space width in dysplasia of the hip: a case-control study of 81 adults followed for ten years. J Bone Joint Surg Br 2005; 87(4): 471-7. doi: 10.1302\/0301-620x.87b4.15522.","DOI":"10.1302\/0301-620X.87B4.15522"},{"key":"168920","doi-asserted-by":"crossref","unstructured":"Hisatome T, Yasunaga Y, Tanaka R, Yamasaki T, Ishida O, Ochi M. Natural course of the minimally symptomatic nonoperated hip in patients with bilateral hip dysplasia treated with contralateral rotational acetabular osteotomy. J Orthop Sci 2005; 10(6): 574-80. doi: 10.1007\/s00776-005-0949-x.","DOI":"10.1007\/s00776-005-0949-x"},{"key":"168921","doi-asserted-by":"crossref","unstructured":"Wyles C C, Heidenreich M J, Jeng J, Larson D R, Trousdale R T, Sierra R J. The John Charnley Award: Redefining the natural history of osteoarthritis in patients with hip dysplasia and impingement. Clin Orthop Relat Res 2017; 475(2): 336-50. doi: 10.1007\/s11999-016-4815-2.","DOI":"10.1007\/s11999-016-4815-2"},{"key":"168922","doi-asserted-by":"crossref","unstructured":"Amagami A, Sugiyama H, Tonotsuka H, Saito M. Long-term course of developmental dysplasia of the hip: follow-up of the non-operated hips of patients undergoing unilateral rotational acetabular osteotomy for twenty-four years. Arch Orthop Trauma Surg 2024;144(3): 997-1004. doi: 10.1007\/s00402-023-05140-1.","DOI":"10.1007\/s00402-023-05140-1"},{"key":"168923","doi-asserted-by":"crossref","unstructured":"Jacobsen S, Sonne-Holm S, Lund B, Soballe K, Kiaer T, Rovsing H, et al. Pelvic orientation and assessment of hip dysplasia in adults. Acta Orthop Scand 2004; 75(6):721-9. doi: 10.1080\/00016470410004094.","DOI":"10.1080\/00016470410004094"},{"key":"168924","doi-asserted-by":"crossref","unstructured":"Kellgren J H, Lawrence J S. Radiological assessment of osteo-arthrosis. Ann Rheum Dis 1957; 16(4): 494-502.","DOI":"10.1136\/ard.16.4.494"},{"key":"168925","doi-asserted-by":"crossref","unstructured":"Jacobsen S, Sonne-Holm S, Soballe K, Gebuhr P, Lund B. Hip dysplasia and osteoarthrosis: a survey of 4151 subjects from the Osteoarthrosis Substudy of the Copenhagen City Heart Study. Acta Orthop 2005; 76(2): 149-58. doi: 10.1080\/00016470510030517.","DOI":"10.1080\/00016470510030517"},{"key":"168926","doi-asserted-by":"crossref","unstructured":"Egund N. Comment on Mittal et al: Defining the lateral edge of the femoroacetabular articulation: correlation analysis between radiographs and computed tomography. J Child Orthop 2017; 11(3): 240-1. doi: 10.1302\/1863-2548.11.170006.","DOI":"10.1302\/1863-2548.11.170006"},{"key":"168927","doi-asserted-by":"crossref","unstructured":"Pereira D, Peleteiro B, Araujo J, Branco J, Santos R A, Ramos E. The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review. Osteoarthritis Cartilage 2011; 19(11): 1270-85. doi: 10.1016\/j.joca.2011.08.009.","DOI":"10.1016\/j.joca.2011.08.009"},{"key":"168928","doi-asserted-by":"crossref","unstructured":"Reijman M, Hazes J M, Pols H A, Koes B W, Bierma-Zeinstra S M. Acetabular dysplasia predicts incident osteoarthritis of the hip: the Rotterdam study. 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Am J Sports Med 2020; 48(9): 2314-23. doi: 10.1177\/0363546519881411.","DOI":"10.1177\/0363546519881411"}],"container-title":["Acta Orthopaedica"],"original-title":[],"link":[{"URL":"https:\/\/actaorthop.org\/actao\/article\/download\/46828\/55533","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actaorthop.org\/actao\/article\/download\/46828\/55549","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actaorthop.org\/actao\/article\/download\/46828\/55550","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actaorthop.org\/actao\/article\/download\/46828\/55533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:53:58Z","timestamp":1790074438000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaorthop.org\/actao\/article\/view\/46828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,22]]},"references-count":25,"URL":"https:\/\/doi.org\/10.2340\/17453674.2026.46828","relation":{},"ISSN":["1745-3682","1745-3674"],"issn-type":[{"value":"1745-3682","type":"electronic"},{"value":"1745-3674","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,22]]}}}