{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:43:42Z","timestamp":1790808222724,"version":"4.1.0"},"reference-count":0,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["www.medicaljournals.se"],"crossmark-restriction":false},"short-container-title":["JRM-CC"],"abstract":"<jats:p>Objective: To evaluate the effects of personalized exposure in vivo on level of physical activity and quality of life in patients with painful diabetic neuro-pathy. \nDesign: Randomized, single-case, ABC design. \nSubjects: Twelve patients with painful diabetic neuropathy, age &gt;18 years, diabetes mellitus type II, Clinical Neurological Examination score &gt;5, Diabetic Neuropathy Symptom Score ?1 and Douleur Neuropathique 4 Questions score ?3. \nMethods: The treatment consists of an Intensive screening, followed by an 8-week exposure in vivo intervention specifically adapted to the needs\/risks of patients with painful diabetic neuropathy, and 6-months follow-up. Outcome measures included daily and non-daily measures of physical activity, quality of life, meta-bolic parameters, disability, depression, general and painful diabetic neuropathy-related anxiety, pain intensity and pain catastrophizing.\nResults: Due to high drop-out rates (n=6 during screening, n=2 during treatment, n=1 after treatment), only 3 participants complet-ed the study. Slight, but non-significant, changes in physical activity and disability were observed. In quality of life, no changes were observed.\nConclusion: Analysis of the reasons for the high drop-out rate indicate that exposure in vivo may have added value in patients with painful diabetic neuropathy only for those patients: (i) whose daily life functioning is impaired mainly by the painful diabetic neuropathy; (ii) in whom painful diabet-ic neuropathy-related fears are exaggerated and irrational; (iii) in whom specific activities evoke the painful diabetic neuropathy-related fears; (iv) whose spouse and healthcare providers are in-volved in the treatment; and (v) who are willing to change their daily behaviour. Further research is needed into this subject.<\/jats:p>","DOI":"10.2340\/20030711-1000046","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T07:52:29Z","timestamp":1612943549000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.2340\/jrm_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effectiveness of exposure in vivo for patients with painful diabetic neuropathy: A pilot study of effects on physical activity and quality of life"],"prefix":"10.2340","volume":"4","author":[{"given":"Charlotte","family":"C.M. van Laake-Geelen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"J.E.M. Smeets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marielle","family":"E.J.B. Goossens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanine","family":"A. Verbunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2021,2,10]]},"container-title":["Journal of Rehabilitation Medicine - Clinical Communications"],"original-title":[],"link":[{"URL":"https:\/\/medicaljournalssweden.se\/jrm-cc\/article\/download\/2660\/4063","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicaljournalssweden.se\/jrm-cc\/article\/download\/2660\/4063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T07:27:05Z","timestamp":1768462025000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicaljournals.se\/jrm\/content\/abstract\/10.2340\/20030711-1000046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,10]]},"references-count":0,"URL":"https:\/\/doi.org\/10.2340\/20030711-1000046","relation":{},"ISSN":["2003-0711"],"issn-type":[{"value":"2003-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,10]]}}}