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The secondary aim was to explore whether pre-treatment vitamin D levels could predict the treatment effect. A prospective observational study was performed, including 20 patients with psoriasis and 15 controls. Serum samples were analyzed for, among others, vitamin D metabolites, vitamin D-binding protein and highly sensitive C-reactive protein. Baseline levels of vitamin D-binding protein were higher in patients with self-reported arthropathy than in those without. After 24 weeks\u2019 treatment, an improvement in psoriasis was noted, as was a decrease in highly sensitive C-reactive protein. Vitamin D-binding protein decreased in those with self-reported arthropathy. Higher baseline levels of vitamin D were associated with faster and greater improvement in psoriasis. Vitamin D-binding protein may have an inflammatory biomarker role.<\/jats:p>","DOI":"10.2340\/actadv.v101.359","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T07:41:29Z","timestamp":1634197289000},"page":"adv00604","source":"Crossref","is-referenced-by-count":11,"title":["Impact of Etanercept on Vitamin D Status and Vitamin D-binding Protein in Bio-na\u00efve Patients with Psoriasis"],"prefix":"10.2340","volume":"101","author":[{"given":"Maria Siekkeri","family":"Vandikas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Landin-Wilhelmsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Polesie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Gillstedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amra","family":"Osmancevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2021,11,24]]},"reference":[{"key":"8673","doi-asserted-by":"crossref","unstructured":"Armstrong AW, Read C. 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