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Stabilized hypochlorous acid\/control (sterile 0.9% NaCl) solutions were assigned to either wound by randomization. Wounds were irrigated and treated on days 0, 2 and 4. Re-epithelialization was assessed blindly by digital planimetry, and bacterial growth was assessed as the number of colony-forming units cultured from surface swabs. Hypochlorous acid solution increased the degree of re-epithelialization on day 4 by 14% compared with the control solution (95% confidence interval (CI) 6.8\u201320%, p\u2009=\u20090.00051) and was not inferior (p\u2009&lt;\u20090.0001) to the control solution on day 10 (0.3%, 95% CI \u20131.3\u20131.9%). Median bacterial counts were lower with stabilized hypochlorous acid compared with control and were further reduced after irrigation and treatment of both groups on day 4, but remained lower in the stabilized hypochlorous acid group compared with the control group. This study demonstrates immediate and durable antimicrobial action and a beneficial effect on acute wound healing after irrigation and treatment with a stabilized hypochlorous acid formulation.<\/jats:p>","DOI":"10.2340\/actadv.v102.1624","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T07:27:36Z","timestamp":1652772456000},"page":"adv00727","source":"Crossref","is-referenced-by-count":27,"title":["Effect of Stabilized Hypochlorous Acid on Re-epithelialization and Bacterial Bioburden in Acute Wounds: A Randomized Controlled Trial in Healthy Volunteers"],"prefix":"10.2340","volume":"102","author":[{"given":"Ewa A.","family":"Burian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubna","family":"Sabah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Kirketerp-M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Gundersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus S.","family":"\u00c5gren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"19171","unstructured":"Anger\u00e5s MH, Brandberg A, Falk A, Seeman T. 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