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A literature search was performed for primary studies on suspected drugs reported to induce delusional infestation. Included articles were evaluated systematically using the Naranjo criteria. In addition, drug mechanisms of action were compared. The final selection included 31 studies, in which a total of 26 classes of drugs were identified. Anti-Parkinson drugs were most frequently associated with delusional infestation, followed by antidepressants, antiepileptics, antibiotics, prescription stimulants, and a few other drug groups. The current available literature suggests that the onset of delusional infestation is initiated by drug-induced alterations in neurotransmitter levels, predominantly dopamine, in the central nervous system.<\/jats:p>","DOI":"10.2340\/actadv.v102.183","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T10:45:59Z","timestamp":1645008359000},"page":"adv00663","source":"Crossref","is-referenced-by-count":13,"title":["Drug-induced Delusional Infestation"],"prefix":"10.2340","volume":"102","author":[{"given":"Patrick M.J.H.","family":"Kemperman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan V.M.","family":"Bruijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nienke C.C.","family":"Vulink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mieke M.C.","family":"Mulder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2022,3,7]]},"reference":[{"key":"16261","doi-asserted-by":"crossref","unstructured":"Hughes JE, Barraclough BM, Hamblin LG, White JE. 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