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Chronic kidney disease severity was determined by the estimated glomerular filtration rate (in ml\/min\/1.73 m2) calculated from serum creatinine, and proteinuria detected with urine dipstick. Prurigo nodularis incidence during follow-up was determined. Over a median follow-up period of 9.72 years, 58,599 individuals developed prurigo nodularis, with an incidence rate of 3.59 per 10,000 person-years. Among different variables, estimated glomerular filtration rate was the strongest risk factor for prurigo nodularis. Compared with estimated glomerular filtration rate \u2265\u200990, estimat-ed glomerular filtration rate 15\u201329 (hazard ratio 1.31, 95% confidence interval 1.05\u20131.62) and end-stage renal disease (hazard ratio 1.46, 95% confidence interval 1.25\u20131.69) were associated with higher risks. The presence of proteinuria independently increased the risk of prurigo nodularis, increased risks associated with estimated glomerular filtration rate 15\u201329 and end-stage renal disease, and caused risk associated with estimated glomerular filtration rate 30\u201359 to become significant. With differential impact of chronic kidney disease severity on the risk of prurigo nodularis, preservation of renal function would potentially translate into lower risk of prurigo nodularis.<\/jats:p>","DOI":"10.2340\/actadv.v102.2227","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T08:28:55Z","timestamp":1660638535000},"page":"adv00781","source":"Crossref","is-referenced-by-count":11,"title":["Impact of Chronic Kidney Disease Severity on the Risk of Prurigo Nodularis: A Population-Based Cohort Study"],"prefix":"10.2340","volume":"102","author":[{"given":"Hei Sung","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Jung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeong Sik","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1183","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"21712","doi-asserted-by":"crossref","unstructured":"Huang AH, Williams KA, Kwatra SG. 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