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It investigates physician- and patient-reported disease severity (Eczema Area and Severity Index (EASI), objective Scoring Atopic Dermatitis (oSCORAD), Investigator Global Assessment, Patient-Oriented Eczema Measure (POEM), Patient Global Assessment (PGA)), patient-reported symptoms (itch, sleep loss, depressive symptoms), therapy courses and dermatological quality of life (DLQI) in moderate-to-severe atopic dermatitis with SCORAD &gt;\u200920. 1,134 atopic dermatitis patients (mean age 41.0\u2009\u00b1\u200914.7 years, 42.5% females) were enrolled by 40 German recruiting sites (dermatological clinics and practices) between June 2016 and April 2021. The current analysis focuses on itch scores obtained with a numerical rating scale (NRS)) documented for the previous 3 days prior to baseline visit. The results show that 97.2% (1,090 of 1,121) patients experienced itch. Itch severity correlated moderately with severity of atopic dermatitis oSCORAD (rho\u2009=\u20090.44 (0.39\u20130.48)) and EASI score (rho\u2009=\u20090.41 (0.36\u20130.46)). A strong correlation was found with self-reported disease severity as PGA (rho\u2009=\u20090.68 (0.65\u20130.71)), POEM sum score (rho\u2009=\u20090.66 (0.63\u20130.69)) and dermatological quality of life impairment DLQI (rho\u2009=\u20090.61 (0.57\u20130.65)). Itch as a subjective complaint is more closely correlated with patient-reported outcomes than with objective assessments by the physician.<\/jats:p>","DOI":"10.2340\/actadv.v103.4426","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T14:02:29Z","timestamp":1674482549000},"page":"adv00854","source":"Crossref","is-referenced-by-count":35,"title":["Itching in Atopic Dermatitis: Patient- and Physician-reported Outcomes in the German Atopic Dermatitis Registry 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