{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:12:34Z","timestamp":1777536754331,"version":"3.51.4"},"reference-count":20,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Derm Venereol"],"abstract":"<jats:p>Abstract is missing (Short communication)<\/jats:p>","DOI":"10.2340\/actadv.v104.14720","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T09:04:37Z","timestamp":1704704677000},"page":"adv14720","source":"Crossref","is-referenced-by-count":1,"title":["Melanoma and LEOPARD Syndrome: Understanding the Role of PTPN11 Mutations in Melanomagenesis"],"prefix":"10.2340","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8353-7481","authenticated-orcid":false,"given":"Rodolfo David","family":"Palacios-Diaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nica","family":"Pozuelo-Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4073-145X","authenticated-orcid":false,"given":"Blanca","family":"De Unamuno-Bustos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita","family":"Llavador-Ros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6153-8192","authenticated-orcid":false,"given":"Rafael","family":"Botella-Estrada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1183","published-online":{"date-parts":[[2024,1,8]]},"reference":[{"key":"45170","doi-asserted-by":"crossref","unstructured":"Zenker M. Clinical overview on RASopathies. Am J Med Genet Part C Semin Med Genet 2022; 190: 414-424.","DOI":"10.1002\/ajmg.c.32015"},{"key":"45171","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1002\/ajmg.c.32015","DOI":"10.1002\/ajmg.c.32015"},{"key":"45172","doi-asserted-by":"crossref","unstructured":"Tajan M, Paccoud R, Branka S, Edouard T, Yart A. The RASopathy family: Consequences of germline activation of the RAS\/MAPK pathway. Endocr Rev 2018; 39: 676-700.","DOI":"10.1210\/er.2017-00232"},{"key":"45173","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1210\/er.2017-00232","DOI":"10.1210\/er.2017-00232"},{"key":"45174","doi-asserted-by":"crossref","unstructured":"Bessis D, Miquel J, Bourrat E, Chiaverini C, Morice-Picard F, Abadie C, et al. Dermatological manifestations in Noonan syndrome: a prospective multicentric study of 129 patients positive for mutation. Br J Dermatol 2019; 180: 1438-1448.","DOI":"10.1111\/bjd.17404"},{"key":"45175","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/bjd.17404","DOI":"10.1111\/bjd.17404"},{"key":"45176","doi-asserted-by":"crossref","unstructured":"Motegi SI, Yokoyama Y, Ogino S, Yamada K, Uchiyama A, Perera B, et al. Pathogenesis of multiple lentigines in LEOPARD syndrome with PTPN11 Gene mutation. Acta Derm Venereol 2015; 95: 978-84.","DOI":"10.2340\/00015555-2123"},{"key":"45177","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.2340\/00015555-2123","DOI":"10.2340\/00015555-2123"},{"key":"45178","doi-asserted-by":"crossref","unstructured":"Smpokou P, Zand DJ, Rosenbaum KN, Summar ML. Malignancy in Noonan syndrome and related disorders. Clin Genet 2015; 88: 516-522.","DOI":"10.1111\/cge.12568"},{"key":"45179","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/cge.12568","DOI":"10.1111\/cge.12568"},{"key":"45180","doi-asserted-by":"crossref","unstructured":"Seishima M, Mizutani Y, Shibuya Y, Arakawa C, Yoshida R, Ogata T. Malignant melanoma in a woman with LEOPARD syndrome: identification of a germline PTPN11 mutation and a somatic BRAF mutation. Br J Dermatol 2007; 157: 1297-1299.","DOI":"10.1111\/j.1365-2133.2007.08229.x"},{"key":"45181","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/j.1365-2133.2007.08229.x","DOI":"10.1111\/j.1365-2133.2007.08229.x"},{"key":"45182","doi-asserted-by":"crossref","unstructured":"Cheng YP, Chiu HY, Hsiao TL, Hsiao CH, Lin CC, Liao YH. Scalp melanoma in a woman with LEOPARD syndrome: possible implication of PTPN11 signaling in melanoma pathogenesis. J Am Acad Dermatol 2013; 69: e186-187.","DOI":"10.1016\/j.jaad.2013.04.033"},{"key":"45183","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1016\/j.jaad.2013.04.033","DOI":"10.1016\/j.jaad.2013.04.033"},{"key":"45184","doi-asserted-by":"crossref","unstructured":"Colmant C, Franck D, Marot L, Matthijs G, Sznajer Y, Blomme S, et al. Patient with confirmed LEOPARD syndrome developing multiple myeloma. Dermatol Pract Concept 2018; 8: 59-62.","DOI":"10.5826\/dpc.0801a14"},{"key":"45185","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.5826\/dpc.0801a14","DOI":"10.5826\/dpc.0801a14"},{"key":"45186","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Gil MF, \u00c1lvarez-Salafranca M, Valero-Torres A, Ara-Mart\u00edn M. Melanoma in Noonan syndrome with multiple lentigines (LEOPARD syndrome): a new case. Actas Dermosifiliogr 2020; 111: 619-621.","DOI":"10.1016\/j.adengl.2020.08.007"},{"key":"45187","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1016\/j.ad.2019.01.017","DOI":"10.1016\/j.ad.2019.01.017"},{"key":"45188","doi-asserted-by":"crossref","unstructured":"Polubothu S, Bender N, Muthiah S, Zecchin D, Demetriou C, Martin SB, et al. PTPN11 mosaicism causes a spectrum of pigmentary and vascular neurocutaneous disorders and predisposes to melanoma. J Invest Dermatol 2023; 143: 1042-1051.e3.","DOI":"10.1016\/j.jid.2022.09.661"},{"key":"45189","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1016\/j.jid.2022.09.661","DOI":"10.1016\/j.jid.2022.09.661"}],"container-title":["Acta Dermato-Venereologica"],"original-title":[],"link":[{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/download\/14720\/42368","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/download\/14720\/42368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T09:05:19Z","timestamp":1704704719000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/view\/14720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,8]]},"references-count":20,"URL":"https:\/\/doi.org\/10.2340\/actadv.v104.14720","relation":{},"ISSN":["1651-2057","0001-5555"],"issn-type":[{"value":"1651-2057","type":"electronic"},{"value":"0001-5555","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1,8]]}}}