{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:15:47Z","timestamp":1793391347489,"version":"4.5.0"},"reference-count":80,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Derm Venereol"],"abstract":"<jats:p>The relevance of the gut microbiota in some skin inflammatory diseases, including acne vulgaris, has been emphasized. Probiotics could play a role in the modulation of the microbiota, improving the clinical course of this disease. A 12-week randomized, double-blind, placebo-controlled, clinical trial with patients aged 12 to 30 years with acne vulgaris was conducted. The study product was a capsule composed of the probiotic Lacticaseibacillus rhamnosus (CECT 30031) and the cyanobacterium Arthrospira platensis (BEA_IDA_0074B). Patients with improvement in the Acne Global Severity Scale were 10\/34 (29.41%) in the placebo group compared with 20\/40 (50%) in the probiotic group (p\u2009=\u20090.03). A significant reduction (p\u2009=\u20090.03) in the number of non-inflammatory acne lesions was observed in the probiotic group (\u201318.60 [\u201324.38 to \u201312.82]) vs the placebo group (\u201310.54 [\u201317.43 to \u20133.66]). Regarding the number of total\u00a0 lesions, a reduction almost reaching statistical significance (p\u2009=\u20090.06) was observed in the probiotic group (\u201327.94 [\u201336.35 to \u201319.53]) compared with the placebo group (\u201318.31 [\u201328.21 to \u20138.41]). In addition, patients with improvement attending the Global Acne Grading System were 7\/34 (20.58%) in the placebo group vs 17\/40 (42.50%) in the probiotic group (p\u2009=\u20090.02). The number of adverse events was similar in both groups. The probiotic used in this study was effective and well tolerated, and it should be considered for acne vulgaris patients.<\/jats:p>","DOI":"10.2340\/actadv.v104.33206","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T06:09:58Z","timestamp":1715839798000},"page":"adv33206","source":"Crossref","is-referenced-by-count":48,"title":["A Randomized Clinical Trial to Evaluate the Efficacy of an Oral Probiotic in Acne Vulgaris"],"prefix":"10.2340","volume":"104","author":[{"given":"Cristina","family":"Eguren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariadna","family":"Navarro-Blasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Corral-Forteza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Reolid-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Set\u00f3-Torrent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Garc\u00eda-Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Prieto-Merino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"N\u00fa\u00f1ez-Delegido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"S\u00e1nchez-Pellicer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Navarro-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"60936","doi-asserted-by":"crossref","unstructured":"Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012; 380: 2163-2196.","DOI":"10.1016\/S0140-6736(12)61729-2"},{"key":"60937","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1016\/S0140-6736(12)61729-2","DOI":"10.1016\/S0140-6736(12)61729-2"},{"key":"60938","doi-asserted-by":"crossref","unstructured":"Heng AHS, Chew FT. Systematic review of the epidemiology of acne vulgaris. Sci Rep 2020; 10: 5754.","DOI":"10.1038\/s41598-020-62715-3"},{"key":"60939","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1038\/s41598-020-62715-3","DOI":"10.1038\/s41598-020-62715-3"},{"key":"60940","doi-asserted-by":"crossref","unstructured":"Bhate K, Williams HC. Epidemiology of acne vulgaris. Br J Dermatol 2013; 168: 474-485.","DOI":"10.1111\/bjd.12149"},{"key":"60941","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/bjd.12149","DOI":"10.1111\/bjd.12149"},{"key":"60942","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Pellicer P, Navarro-Moratalla L, N\u00fa\u00f1ez-Delegido E, Ruzafa-Costas B, Ag\u00fcera-Santos J, Navarro-L\u00f3pez V. Acne, microbiome, and probiotics: the gut-skin axis. Microorganisms 2022; 10: 1303.","DOI":"10.3390\/microorganisms10071303"},{"key":"60943","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.3390\/microorganisms10071303","DOI":"10.3390\/microorganisms10071303"},{"key":"60944","doi-asserted-by":"crossref","unstructured":"Ottaviani M, Camera E, Picardo M. Lipid mediators in acne. Mediators Inflamm 2010; 2010: 858176.","DOI":"10.1155\/2010\/858176"},{"key":"60945","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1155\/2010\/858176","DOI":"10.1155\/2010\/858176"},{"key":"60946","doi-asserted-by":"crossref","unstructured":"Hu T, Wei Z, Ju Q, Chen W. Sex hormones and acne: state of the art. J Dtsch Dermatol Ges 2021; 19: 509-515.","DOI":"10.1111\/ddg.14426"},{"key":"60947","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/ddg.14426","DOI":"10.1111\/ddg.14426"},{"key":"60948","doi-asserted-by":"crossref","unstructured":"Melnik BC. Linking diet to acne metabolomics, inflammation, and comedogenesis: an update. Clin Cosmet Investig Dermatol 2015; 8: 371-388.","DOI":"10.2147\/CCID.S69135"},{"key":"60949","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.2147\/CCID.S69135","DOI":"10.2147\/CCID.S69135"},{"key":"60950","doi-asserted-by":"crossref","unstructured":"Kwon HH, Yoon JY, Park SY, Suh DH. Analysis of distribution patterns of Propionibacterium acnes phylotypes and Peptostreptococcus species from acne lesions. Br J Dermatol 2013; 169: 1152-1155.","DOI":"10.1111\/bjd.12486"},{"key":"60951","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/bjd.12486","DOI":"10.1111\/bjd.12486"},{"key":"60952","doi-asserted-by":"crossref","unstructured":"Barnard E, Shi B, Kang D, Craft N, Li H. The balance of metagenomic elements shapes the skin microbiome in acne and health. Sci Rep 2016; 6: 39491.","DOI":"10.1038\/srep39491"},{"key":"60953","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1038\/srep39491","DOI":"10.1038\/srep39491"},{"key":"60954","doi-asserted-by":"crossref","unstructured":"Johnson T, Kang D, Barnard E, Li H. Strain-level differences in porphyrin production and regulation in propionibacterium acnes elucidate disease associations. mSphere 2016; 1: e00023-15.","DOI":"10.1128\/mSphere.00023-15"},{"key":"60955","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1128\/mSphere.00023-15","DOI":"10.1128\/mSphere.00023-15"},{"key":"60956","doi-asserted-by":"crossref","unstructured":"Coenye T, Spittaels KJ, Achermann Y. The role of biofilm formation in the pathogenesis and antimicrobial susceptibility of cutibacterium acnes. Biofilm 2022; 4: 100063.","DOI":"10.1016\/j.bioflm.2021.100063"},{"key":"60957","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1016\/j.bioflm.2021.100063","DOI":"10.1016\/j.bioflm.2021.100063"},{"key":"60958","doi-asserted-by":"crossref","unstructured":"Jahns AC, Lundskog B, Ganceviciene R, Palmer RH, Golovleva I, Zouboulis CC, et al. An increased incidence of Propionibacterium acnes biofilms in acne vulgaris: a case-control study. Br J Dermatol 2012; 167: 50-58.","DOI":"10.1111\/j.1365-2133.2012.10897.x"},{"key":"60959","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/j.1365-2133.2012.10897.x","DOI":"10.1111\/j.1365-2133.2012.10897.x"},{"key":"60960","doi-asserted-by":"crossref","unstructured":"Yu Y, Champer J, Agak GW, Kao S, Modlin RL, Kim J. Different Propionibacterium acnes phylotypes induce distinct immune responses and express unique surface and secreted proteomes. J Invest Dermatol 2016;1 36: 2221-2228.","DOI":"10.1016\/j.jid.2016.06.615"},{"key":"60961","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1016\/j.jid.2016.06.615","DOI":"10.1016\/j.jid.2016.06.615"},{"key":"60962","doi-asserted-by":"crossref","unstructured":"Nast A, Dr\u00e9no B, Bettoli V, Bukvic Mokos Z, Degitz K, Dressler C, et al. European evidence-based (S3) guideline for the treatment of acne - update 2016 - short version. J Eur Acad Dermatol Venereol 2016; 30: 1261-1268.","DOI":"10.1111\/jdv.13776"},{"key":"60963","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/jdv.13776","DOI":"10.1111\/jdv.13776"},{"key":"60964","doi-asserted-by":"crossref","unstructured":"Walsh TR, Efthimiou J, Dr\u00e9no B. Systematic review of antibiotic resistance in acne: an increasing topical and oral threat. Lancet Infect Dis 2016; 16: e23-33.","DOI":"10.1016\/S1473-3099(15)00527-7"},{"key":"60965","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1016\/S1473-3099(15)00527-7","DOI":"10.1016\/S1473-3099(15)00527-7"},{"key":"60966","doi-asserted-by":"crossref","unstructured":"Garner SE, Eady A, Bennett C, Newton JN, Thomas K, Popescu CM. Minocycline for acne vulgaris: efficacy and safety. Cochrane Database Syst Rev 2012; 2012: CD002086.","DOI":"10.1002\/14651858.CD002086.pub2"},{"key":"60967","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1002\/14651858.CD002086.pub2","DOI":"10.1002\/14651858.CD002086.pub2"},{"key":"60968","doi-asserted-by":"crossref","unstructured":"Salem I, Ramser A, Isham N, Ghannoum MA. The gut microbiome as a major regulator of the gut-skin axis. Front Microbiol 2018; 9: 1459.","DOI":"10.3389\/fmicb.2018.01459"},{"key":"60969","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.3389\/fmicb.2018.01459","DOI":"10.3389\/fmicb.2018.01459"},{"key":"60970","doi-asserted-by":"crossref","unstructured":"Gilbert JA, Blaser MJ, Caporaso JG, Jansson JK, Lynch SV, Knight R. Current understanding of the human microbiome. Nat Med 2018; 24: 392-400.","DOI":"10.1038\/nm.4517"},{"key":"60971","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1038\/nm.4517","DOI":"10.1038\/nm.4517"},{"key":"60972","doi-asserted-by":"crossref","unstructured":"Wensel CR, Pluznick JL, Salzberg SL, Sears CL. Next-generation sequencing: insights to advance clinical investigations of the microbiome. J Clin Invest 2022; 132: e154944.","DOI":"10.1172\/JCI154944"},{"key":"60973","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1172\/JCI154944","DOI":"10.1172\/JCI154944"},{"key":"60974","doi-asserted-by":"crossref","unstructured":"Deng Y, Wang H, Zhou J, Mou Y, Wang G, Xiong X. Patients with acne vulgaris have a distinct gut microbiota in comparison with healthy controls. Acta Derm Venereol 2018; 98: 783-790.","DOI":"10.2340\/00015555-2968"},{"key":"60975","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.2340\/00015555-2968","DOI":"10.2340\/00015555-2968"},{"key":"60976","doi-asserted-by":"crossref","unstructured":"Huang Y, Liu L, Chen L, Zhou L, Xiong X, Deng Y. Gender-specific differences in gut microbiota composition associated with microbial metabolites for patients with acne vulgaris. Ann Dermatol 2021; 33: 531-540.","DOI":"10.5021\/ad.2021.33.6.531"},{"key":"60977","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.5021\/ad.2021.33.6.531","DOI":"10.5021\/ad.2021.33.6.531"},{"key":"60978","doi-asserted-by":"crossref","unstructured":"Koh A, De Vadder F, Kovatcheva-Datchary P, B\u00e4ckhed F. From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell 2016; 165: 1332-1345.","DOI":"10.1016\/j.cell.2016.05.041"},{"key":"60979","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1016\/j.cell.2016.05.041","DOI":"10.1016\/j.cell.2016.05.041"},{"key":"60980","doi-asserted-by":"crossref","unstructured":"Kim CH. Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids. Cell Mol Immunol 2021; 18: 1161-1171.","DOI":"10.1038\/s41423-020-00625-0"},{"key":"60981","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1038\/s41423-020-00625-0","DOI":"10.1038\/s41423-020-00625-0"},{"key":"60982","doi-asserted-by":"crossref","unstructured":"Usuda H, Okamoto T, Wada K. leaky gut: effect of dietary fiber and fats on microbiome and intestinal barrier. Int J Mol Sci 2021; 22: 7613.","DOI":"10.3390\/ijms22147613"},{"key":"60983","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.3390\/ijms22147613","DOI":"10.3390\/ijms22147613"},{"key":"60984","doi-asserted-by":"crossref","unstructured":"Navarro-L\u00f3pez V, N\u00fa\u00f1ez-Delegido E, Ruzafa-Costas B, S\u00e1nchez-Pellicer P, Ag\u00fcera-Santos J, Navarro-Moratalla L. Probiotics in the therapeutic arsenal of dermatologists. Microorganisms 2021; 9: 1513.","DOI":"10.3390\/microorganisms9071513"},{"key":"60985","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.3390\/microorganisms9071513","DOI":"10.3390\/microorganisms9071513"},{"key":"60986","doi-asserted-by":"crossref","unstructured":"Jung GW, Tse JE, Guiha I, Rao J. Prospective, randomized, open-label trial comparing the safety, efficacy, and tolerability of an acne treatment regimen with and without a probiotic supplement and minocycline in subjects with mild to moderate acne. J Cutan Med Surg 2013; 17: 114-122.","DOI":"10.2310\/7750.2012.12026"},{"key":"60987","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.2310\/7750.2012.12026","DOI":"10.2310\/7750.2012.12026"},{"key":"60988","doi-asserted-by":"crossref","unstructured":"Fabbrocini G, Bertona M, Picazo \u00d3, Pareja-Galeano H, Monfrecola G, Emanuele E. Supplementation with Lactobacillus rhamnosus SP1 normalises skin expression of genes implicated in insulin signalling and improves adult acne. Benef Microbes 2016; 7: 625-630.","DOI":"10.3920\/BM2016.0089"},{"key":"60989","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.3920\/BM2016.0089","DOI":"10.3920\/BM2016.0089"},{"key":"60990","doi-asserted-by":"crossref","unstructured":"Tolino E, Skroza N, Mambrin A, Bernardini N, Zuber S, Balduzzi V, et al. Novel combination for the treatment of acne differentiated based on gender: a new step towards personalized treatment. G Ital Dermatol Venereol 2018; 153: 866-871.","DOI":"10.23736\/S0392-0488.18.05710-3"},{"key":"60991","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.23736\/S0392-0488.18.05710-3","DOI":"10.23736\/S0392-0488.18.05710-3"},{"key":"60992","doi-asserted-by":"crossref","unstructured":"Manzhalii E, Hornuss D, Stremmel W. Intestinal-borne dermatoses significantly improved by oral application of Escherichia coli Nissle 1917. World J Gastroenterol 2016; 22: 5415-5421.","DOI":"10.3748\/wjg.v22.i23.5415"},{"key":"60993","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.3748\/wjg.v22.i23.5415","DOI":"10.3748\/wjg.v22.i23.5415"},{"key":"60994","doi-asserted-by":"crossref","unstructured":"Rinaldi F, Marotta L, Mascolo A, Amoruso A, Pane M, Giuliani G, et al. Facial acne: a randomized, double-blind, placebo-controlled study on the clinical efficacy of a symbiotic dietary supplement. Dermatol Ther (Heidelb) 2022; 12: 577-589.","DOI":"10.1007\/s13555-021-00664-z"},{"key":"60995","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1007\/s13555-021-00664-z","DOI":"10.1007\/s13555-021-00664-z"},{"key":"60996","doi-asserted-by":"crossref","unstructured":"Chen L, Li H, Li J, Chen Y, Yang Y. Lactobacillus rhamnosus GG treatment improves intestinal permeability and modulates microbiota dysbiosis in an experimental model of sepsis. Int J Mol Med 2019; 43: 1139-1148.","DOI":"10.3892\/ijmm.2019.4050"},{"key":"60997","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.3892\/ijmm.2019.4050","DOI":"10.3892\/ijmm.2019.4050"},{"key":"60998","doi-asserted-by":"crossref","unstructured":"Panpetch W, Hiengrach P, Nilgate S, Tumwasorn S, Somboonna N, Wilantho A, et al. Additional candida albicans administration enhances the severity of dextran sulfate solution induced colitis mouse model through leaky gut-enhanced systemic inflammation and gut-dysbiosis but attenuated by Lactobacillus rhamnosus L34. Gut Microbes 2020; 11: 465-480.","DOI":"10.1080\/19490976.2019.1662712"},{"key":"60999","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1080\/19490976.2019.1662712","DOI":"10.1080\/19490976.2019.1662712"},{"key":"61000","doi-asserted-by":"crossref","unstructured":"Jia L, Wu R, Han N, Fu J, Luo Z, Guo L, et al. Porphyromonas gingivalis and Lactobacillus rhamnosus GG regulate the Th17\/Treg balance in colitis via TLR4 and TLR2. Clin Transl Immunology 2020; 9: e1213.","DOI":"10.1002\/cti2.1213"},{"key":"61001","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1002\/cti2.1213","DOI":"10.1002\/cti2.1213"},{"key":"61002","unstructured":"Chen JF, Zhuang Y, Jin SB, Zhang SL, Yang WW. Probiotic lactobacillus rhamnosus GG (LGG) restores intestinal dysbacteriosis to alleviate upregulated inflammatory cytokines triggered by femoral diaphyseal fracture in adolescent rodent model. Eur Rev Med Pharmacol Sci 2021; 25: 376-389."},{"key":"61003","doi-asserted-by":"crossref","unstructured":"Nihal B, Gupta NV, Gowda D, Mariapan M. Formulation and development of topical anti acne formulation of spirulina extract. Int J Appl Pharm 2018; 10: 229-233.","DOI":"10.22159\/ijap.2018v10i6.26334"},{"key":"61004","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.22159\/ijap.2018v10i6.26334","DOI":"10.22159\/ijap.2018v10i6.26334"},{"key":"61005","doi-asserted-by":"crossref","unstructured":"Dranseikien\u0117 D, Bal\u010di\u016bnait\u0117-Murzien\u0117 G, Karosien\u0117 J, Morudov D, Juod\u017eiukynien\u0117 N, Hudz N, et al. Cyano- phycocyanin: mechanisms of action on human skin and future perspectives in medicine. Plants (Basel) 2022; 11: 1249.","DOI":"10.3390\/plants11091249"},{"key":"61006","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.3390\/plants11091249","DOI":"10.3390\/plants11091249"},{"key":"61007","doi-asserted-by":"crossref","unstructured":"Kellett SC, Gawkrodger DJ. The psychological and emotional impact of acne and the effect of treatment with isotretinoin. Br J Dermatol 1999; 140: 273-282.","DOI":"10.1046\/j.1365-2133.1999.02662.x"},{"key":"61008","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1046\/j.1365-2133.1999.02662.x","DOI":"10.1046\/j.1365-2133.1999.02662.x"},{"key":"61009","doi-asserted-by":"crossref","unstructured":"Mirdamadi Y, Bommhardt U, Goihl A, Guttek K, Zouboulis CC, Quist S, et al. Insulin and insulin-like growth factor-1 can activate the phosphoinositide-3-kinase \/Akt\/FoxO1 pathway in T cells in vitro. Dermatoendocrinol 2017; 9: e1356518.","DOI":"10.1080\/19381980.2017.1356518"},{"key":"61010","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1080\/19381980.2017.1356518","DOI":"10.1080\/19381980.2017.1356518"},{"key":"61011","unstructured":"Melnik BC. The role of transcription factor FoxO1 in the pathogenesis of acne vulgaris and the mode of isotretinoin action. G Ital Dermatol Venereol 2010; 145: 559-571."},{"key":"61012","doi-asserted-by":"crossref","unstructured":"Dall'Oglio F, Nasca MR, Fiorentini F, Micali G. Diet and acne: review of the evidence from 2009 to 2020. Int J Dermatol 2021; 60: 672-685.","DOI":"10.1111\/ijd.15390"},{"key":"61013","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/ijd.15390","DOI":"10.1111\/ijd.15390"},{"key":"61014","doi-asserted-by":"crossref","unstructured":"Rocha MA, Bagatin E. Adult-onset acne: prevalence, impact, and management challenges. Clin Cosmet Investig Dermatol 2018; 11: 59-69.","DOI":"10.2147\/CCID.S137794"},{"key":"61015","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.2147\/CCID.S137794","DOI":"10.2147\/CCID.S137794"}],"container-title":["Acta Dermato-Venereologica"],"original-title":[],"link":[{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/download\/33206\/46179","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/download\/33206\/46179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T06:10:33Z","timestamp":1715839833000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/view\/33206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,15]]},"references-count":80,"URL":"https:\/\/doi.org\/10.2340\/actadv.v104.33206","relation":{},"ISSN":["1651-2057","0001-5555"],"issn-type":[{"value":"1651-2057","type":"electronic"},{"value":"0001-5555","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5,15]]}}}