{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T14:59:31Z","timestamp":1777215571084,"version":"3.51.4"},"reference-count":76,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Derm Venereol"],"abstract":"<jats:p>Vitamin D plays a role in inflammatory skin conditions and can improve them. Hidradenitis suppurativa (HS) is an autoinflammatory chronic skin disease in which most patients exhibit a hypovitaminosis D. However, it is uncertain whether vitamin D supplementation could relieve the severity of HS. A systematic literature search of PubMed and Web of Science was conducted on 4 September 2023. Studies that investigated vitamin D and its potential implications for the severity of HS were included. In contrast, studies that focused on the prevalence of vitamin D deficiency were excluded, as well as studies on syndromic HS. Seven studies with a total of 575 patients were included in the qualitative synthesis, of which 3 utilized a cross-sectional design, 2 were pilot studies, 1 a controlled cohort study, and 1 a prospective case-control study. In all included studies, HS patients were vitamin D deficient. There was evidence indicating that serum vitamin D levels negatively correlated with the severity of the disease, and at least suggestive evidence that vitamin D supplementation could have a positive impact on the course of HS. To better understand these correlations, conducting a randomized controlled trial study on vitamin D and its effects on HS severity is imperative.<\/jats:p>","DOI":"10.2340\/actadv.v104.40321","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T12:20:41Z","timestamp":1725970841000},"page":"adv40321","source":"Crossref","is-referenced-by-count":7,"title":["To what Extent does Vitamin D and its Serum Levels Influence the Severity of Hidradenitis Suppurativa: A Literature Review"],"prefix":"10.2340","volume":"104","author":[{"given":"Lea","family":"Lackner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit-Christiane","family":"Zyriax","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Stephan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1183","published-online":{"date-parts":[[2024,9,10]]},"reference":[{"key":"75042","doi-asserted-by":"crossref","unstructured":"Zouboulis CC, Benhadou F, Byrd AS, Chandran NS, Giamarellos-Bourboulis EJ, Fabbrocini G, et al. What causes hidradenitis suppurativa? - 15 years after. Exp Dermatol 2020; 29: 1154-1170.","DOI":"10.1111\/exd.14214"},{"key":"75043","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/exd.14214","DOI":"10.1111\/exd.14214"},{"key":"75044","doi-asserted-by":"crossref","unstructured":"Sabat R, Jemec GBE, Matusiak L, Kimball AB, Prens E, Wolk K. Hidradenitis suppurativa. Nat Rev Dis Primers 2020; 6: 18.","DOI":"10.1038\/s41572-020-0149-1"},{"key":"75045","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1038\/s41572-020-0149-1","DOI":"10.1038\/s41572-020-0149-1"},{"key":"75046","doi-asserted-by":"crossref","unstructured":"Wolk K, Join-Lambert O, Sabat R. Aetiology and pathogenesis of hidradenitis suppurativa. Br J Dermatol 2020; 183: 999-1010.","DOI":"10.1111\/bjd.19556"},{"key":"75047","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/bjd.19556","DOI":"10.1111\/bjd.19556"},{"key":"75048","doi-asserted-by":"crossref","unstructured":"Martorell A, Garcia-Martinez FJ, Jimenez-Gallo D, Pascual JC, Pereyra-Rodriguez J, Salgado L, et al. An update on hidradenitis suppurativa (part i): epidemiology, clinical aspects, and definition of disease severity. Actas Dermosifiliogr 2015; 106: 703-715.","DOI":"10.1016\/j.adengl.2015.09.008"},{"key":"75049","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1016\/j.ad.2015.06.004","DOI":"10.1016\/j.ad.2015.06.004"},{"key":"75050","doi-asserted-by":"crossref","unstructured":"Goldburg SR, Strober BE, Payette MJ. Hidradenitis suppurativa: epidemiology, clinical presentation, and pathogenesis. J Am Acad Dermatol 2020; 82: 1045-1058.","DOI":"10.1016\/j.jaad.2019.08.090"},{"key":"75051","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1016\/j.jaad.2019.08.090","DOI":"10.1016\/j.jaad.2019.08.090"},{"key":"75052","doi-asserted-by":"crossref","unstructured":"Hessam S, Sand M, Gambichler T, Skrygan M, Ruddel I, Bechara FG. Interleukin-36 in hidradenitis suppurativa: evidence for a distinctive proinflammatory role and a key factor in the development of an inflammatory loop. Br J Dermatol 2018; 178: 761-767.","DOI":"10.1111\/bjd.16019"},{"key":"75053","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/bjd.16019","DOI":"10.1111\/bjd.16019"},{"key":"75054","doi-asserted-by":"crossref","unstructured":"Lima AL, Karl I, Giner T, Poppe H, Schmidt M, Presser D, et al. Keratinocytes and neutrophils are important sources of proinflammatory molecules in hidradenitis suppurativa. Br J Dermatol 2016; 174: 514-521.","DOI":"10.1111\/bjd.14214"},{"key":"75055","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/bjd.14214","DOI":"10.1111\/bjd.14214"},{"key":"75056","doi-asserted-by":"crossref","unstructured":"Schlapbach C, Hanni T, Yawalkar N, Hunger RE. Expression of the IL-23\/Th17 pathway in lesions of hidradenitis suppurativa. J Am Acad Dermatol 2011; 65: 790-798.","DOI":"10.1016\/j.jaad.2010.07.010"},{"key":"75057","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1016\/j.jaad.2010.07.010","DOI":"10.1016\/j.jaad.2010.07.010"},{"key":"75058","doi-asserted-by":"crossref","unstructured":"Agamia NF, Sorror OA, Sayed NM, Ghazala RA, Echy SM, Moussa DH, et al. Overexpression of hypoxia-inducible factor-1alpha in hidradenitis suppurativa: the link between deviated immunity and metabolism. Arch Dermatol Res 2023; 315: 2107-2118.","DOI":"10.1007\/s00403-023-02594-6"},{"key":"75059","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1007\/s00403-023-02594-6","DOI":"10.1007\/s00403-023-02594-6"},{"key":"75060","doi-asserted-by":"crossref","unstructured":"Gulliver W, Zouboulis CC, Prens E, Jemec GB, Tzellos T. Evidence-based approach to the treatment of hidradenitis suppurativa\/acne inversa, based on the European guidelines for hidradenitis suppurativa. Rev Endocr Metab Disord 2016; 17: 343-351.","DOI":"10.1007\/s11154-016-9328-5"},{"key":"75061","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1007\/s11154-016-9328-5","DOI":"10.1007\/s11154-016-9328-5"},{"key":"75062","doi-asserted-by":"crossref","unstructured":"Zouboulis CC, Desai N, Emtestam L, Hunger RE, Ioannides D, Juhasz I, et al. European S1 guideline for the treatment of hidradenitis suppurativa\/acne inversa. J Eur Acad Dermatol Venereol 2015; 29: 619-644.","DOI":"10.1111\/jdv.12966"},{"key":"75063","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/jdv.12966","DOI":"10.1111\/jdv.12966"},{"key":"75064","doi-asserted-by":"crossref","unstructured":"Hendricks AJ, Hsiao JL, Lowes MA, Shi VY. A comparison of international management guidelines for hidradenitis suppurativa. Dermatology 2021; 237: 81-96.","DOI":"10.1159\/000503605"},{"key":"75065","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1159\/000503605","DOI":"10.1159\/000503605"},{"key":"75066","doi-asserted-by":"crossref","unstructured":"Kechichian E, Ezzedine K. Vitamin D and the skin: an update for dermatologists. Am J Clin Dermatol 2018; 19: 223-235.","DOI":"10.1007\/s40257-017-0323-8"},{"key":"75067","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1007\/s40257-017-0323-8","DOI":"10.1007\/s40257-017-0323-8"},{"key":"75068","doi-asserted-by":"crossref","unstructured":"Passeron T, Bouillon R, Callender V, Cestari T, Diepgen TL, Green AC, et al. Sunscreen photoprotection and vitamin D status. Br J Dermatol 2019; 181: 916-931.","DOI":"10.1111\/bjd.17992"},{"key":"75069","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/bjd.17992","DOI":"10.1111\/bjd.17992"},{"key":"75070","doi-asserted-by":"crossref","unstructured":"Brandao L, Moura R, Tricarico PM, Gratton R, Genovese G, Moltrasio C, et al. Altered keratinization and vitamin D metabolism may be key pathogenetic pathways in syndromic hidradenitis suppurativa: a novel whole exome sequencing approach. J Dermatol Sci 2020; 99: 17-22.","DOI":"10.1016\/j.jdermsci.2020.05.004"},{"key":"75071","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1016\/j.jdermsci.2020.05.004","DOI":"10.1016\/j.jdermsci.2020.05.004"},{"key":"75072","doi-asserted-by":"crossref","unstructured":"Weber I, Giefer J, Martin KL. Effects of exercise and dietary modifications on hidradenitis suppurativa: a systematic review. Am J Clin Dermatol 2023; 24: 343-357.","DOI":"10.1007\/s40257-023-00756-w"},{"key":"75073","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1007\/s40257-023-00756-w","DOI":"10.1007\/s40257-023-00756-w"},{"key":"75074","doi-asserted-by":"crossref","unstructured":"Kelly G, Sweeney CM, Fitzgerald R, O'Keane MP, Kilbane M, Lally A, et al. Vitamin D status in hidradenitis suppurativa. Br J Dermatol 2014; 170: 1379-1380.","DOI":"10.1111\/bjd.12900"},{"key":"75075","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/bjd.12900","DOI":"10.1111\/bjd.12900"},{"key":"75076","doi-asserted-by":"crossref","unstructured":"Lee JW, Heo YW, Lee JH, Lee S. Epidemiology and comorbidity of hidradenitis suppurativa in Korea for 17 years: a nationwide population-based cohort study. J Dermatol 2023; 50: 778-786.","DOI":"10.1111\/1346-8138.16747"},{"key":"75077","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/1346-8138.16747","DOI":"10.1111\/1346-8138.16747"},{"key":"75078","unstructured":"Kirsten N, Mohr N, Augustin M, Hilbring C, Girbig G, Neumann F, et al. Abstract 106: vitamin D and its correlation with the BMI and the MEDAS-Score in patients with hidradenitis suppurativa: results of a monocentric cross-sectional study. J Dtsch Dermatol Ges 2021; 19: 53."},{"key":"75079","doi-asserted-by":"crossref","unstructured":"Seetan K, Eldos B, Saraireh M, Omari R, Rubbai Y, Jayyusi A, et al. Prevalence of low vitamin D levels in patients with hidradenitis suppurativa in Jordan: a comparative cross-sectional study. PLoS One 2022; 17: e0265672.","DOI":"10.1371\/journal.pone.0265672"},{"key":"75080","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1371\/journal.pone.0265672","DOI":"10.1371\/journal.pone.0265672"},{"key":"75081","doi-asserted-by":"crossref","unstructured":"Navarro I, Gonzalez-Lopez MA, Sierra I, Olmos JM, Blanco R, Hernandez JL. Bone metabolism in patients with hidradenitis suppurativa: a case-control study. Acta Derm Venereol 2022; 102: adv00825.","DOI":"10.2340\/actadv.v102.3504"},{"key":"75082","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.2340\/actadv.v102.3504","DOI":"10.2340\/actadv.v102.3504"},{"key":"75083","doi-asserted-by":"crossref","unstructured":"Sanchez-Diaz M, Salvador-Rodriguez L, Montero-Vilchez T, Martinez-Lopez A, Arias-Santiago S, Molina-Leyva A. Cumulative inflammation and HbA1c levels correlate with increased intima-media thickness in patients with severe hidradenitis suppurativa. J Clin Med 2021; 10: 5222.","DOI":"10.3390\/jcm10225222"},{"key":"75084","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.3390\/jcm10225222","DOI":"10.3390\/jcm10225222"},{"key":"75085","doi-asserted-by":"crossref","unstructured":"Moltrasio C, Tricarico PM, Genovese G, Gratton R, Marzano AV, Crovella S. 25-Hydroxyvitamin D serum levels inversely correlate to disease severity and serum C-reactive protein levels in patients with hidradenitis suppurativa. J Dermatol 2021; 48: 715-717.","DOI":"10.1111\/1346-8138.15797"},{"key":"75086","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/1346-8138.15797","DOI":"10.1111\/1346-8138.15797"},{"key":"75087","doi-asserted-by":"crossref","unstructured":"Fabbrocini G, Marasca C, Luciano MA, Guarino M, Poggi S, Fontanella G, et al. Vitamin D deficiency and hidradenitis suppurativa: the impact on clinical severity and therapeutic responsivity. J Dermatolog Treat 2021; 32: 843-844.","DOI":"10.1080\/09546634.2020.1714538"},{"key":"75088","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1080\/09546634.2020.1714538","DOI":"10.1080\/09546634.2020.1714538"},{"key":"75089","unstructured":"Ricceri F, Pescitelli L, Di Cesare A, Rosi E, Prignano F. 053 OS11-02 - oral session: serum vitamin D in hidradenitis suppurativa patients: a pilot study. Exp Dermatol 2019; 28: 28."},{"key":"75090","doi-asserted-by":"crossref","unstructured":"Guillet A, Brocard A, Bach Ngohou K, Graveline N, Leloup AG, Ali D, et al. Verneuil's disease, innate immunity and vitamin D: a pilot study. J Eur Acad Dermatol Venereol 2015; 29: 1347-1353.","DOI":"10.1111\/jdv.12857"},{"key":"75091","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/jdv.12857","DOI":"10.1111\/jdv.12857"},{"key":"75092","doi-asserted-by":"crossref","unstructured":"Olmos JM, Hernandez JL, Garcia-Velasco P, Martinez J, Llorca J, Gonzalez-Macias J. Serum 25-hydroxyvitamin D, parathyroid hormone, calcium intake, and bone mineral density in Spanish adults. Osteoporos Int 2016; 27: 105-113.","DOI":"10.1007\/s00198-015-3219-6"},{"key":"75093","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1007\/s00198-015-3219-6","DOI":"10.1007\/s00198-015-3219-6"},{"key":"75094","doi-asserted-by":"crossref","unstructured":"Martinez J, Olmos JM, Hernandez JL, Pinedo G, Llorca J, Obregon E, et al. Bone turnover markers in Spanish postmenopausal women: the Camargo cohort study. Clin Chim Acta 2009; 409: 70-74.","DOI":"10.1016\/j.cca.2009.08.020"},{"key":"75095","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1016\/j.cca.2009.08.020","DOI":"10.1016\/j.cca.2009.08.020"},{"key":"75096","doi-asserted-by":"crossref","unstructured":"Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011; 96: 1911-1930.","DOI":"10.1210\/jc.2011-0385"},{"key":"75097","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1210\/jc.2011-0385","DOI":"10.1210\/jc.2011-0385"},{"key":"75098","doi-asserted-by":"crossref","unstructured":"Lim SK, Ha JM, Lee YH, Lee Y, Seo YJ, Kim CD, et al. Comparison of vitamin D levels in patients with and without acne: a case-control study combined with a randomized controlled. Trial PLoS One 2016; 11: e0161162.","DOI":"10.1371\/journal.pone.0161162"},{"key":"75099","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1371\/journal.pone.0161162","DOI":"10.1371\/journal.pone.0161162"},{"key":"75100","doi-asserted-by":"crossref","unstructured":"Barrea L, Savanelli MC, Di Somma C, Napolitano M, Megna M, Colao A, et al. Vitamin D and its role in psoriasis: an overview of the dermatologist and nutritionist. Rev Endocr Metab Disord 2017; 18: 195-205.","DOI":"10.1007\/s11154-017-9411-6"},{"key":"75101","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1007\/s11154-017-9411-6","DOI":"10.1007\/s11154-017-9411-6"},{"key":"75102","doi-asserted-by":"crossref","unstructured":"Bergler-Czop B, Brzezinska-Wcislo L. Serum vitamin D level: the effect on the clinical course of psoriasis. Postepy Dermatol Alergol 2016; 33: 445-449.","DOI":"10.5114\/ada.2016.63883"},{"key":"75103","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.5114\/ada.2016.63883","DOI":"10.5114\/ada.2016.63883"},{"key":"75104","doi-asserted-by":"crossref","unstructured":"Afzal S, Brondum-Jacobsen P, Bojesen SE, Nordestgaard BG. Vitamin D concentration, obesity, and risk of diabetes: a mendelian randomisation study. Lancet Diabetes Endocrinol 2014; 2: 298-306.","DOI":"10.1016\/S2213-8587(13)70200-6"},{"key":"75105","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1016\/S2213-8587(13)70200-6","DOI":"10.1016\/S2213-8587(13)70200-6"},{"key":"75106","doi-asserted-by":"crossref","unstructured":"Pereira-Santos M, Costa PR, Assis AM, Santos CA, Santos DB. Obesity and vitamin D deficiency: a systematic review and meta-analysis. Obes Rev 2015; 16: 341-349.","DOI":"10.1111\/obr.12239"},{"key":"75107","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/obr.12239","DOI":"10.1111\/obr.12239"},{"key":"75108","doi-asserted-by":"crossref","unstructured":"Tzellos T, Zouboulis CC, Gulliver W, Cohen AD, Wolkenstein P, Jemec GB. Cardiovascular disease risk factors in patients with hidradenitis suppurativa: a systematic review and meta-analysis of observational studies. Br J Dermatol 2015; 173: 1142-1155.","DOI":"10.1111\/bjd.14024"},{"key":"75109","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/bjd.14024","DOI":"10.1111\/bjd.14024"},{"key":"75110","doi-asserted-by":"crossref","unstructured":"Waldron JL, Ashby HL, Cornes MP, Bechervaise J, Razavi C, Thomas OL, et al. Vitamin D: a negative acute phase reactant. J Clin Pathol 2013; 66: 620-622.","DOI":"10.1136\/jclinpath-2012-201301"},{"key":"75111","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1136\/jclinpath-2012-201301","DOI":"10.1136\/jclinpath-2012-201301"},{"key":"75112","doi-asserted-by":"crossref","unstructured":"Lee WJ, Cha HW, Sohn MY, Lee SJ, Kim DW. Vitamin D increases expression of cathelicidin in cultured sebocytes. Arch Dermatol Res 2012; 304: 627-632.","DOI":"10.1007\/s00403-012-1255-z"},{"key":"75113","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1007\/s00403-012-1255-z","DOI":"10.1007\/s00403-012-1255-z"},{"key":"75114","doi-asserted-by":"crossref","unstructured":"An JH, Cho DH, Lee GY, Kang MS, Kim SJ, Han SN. Effects of vitamin D supplementation on CD4+ T cell subsets and mTOR signaling pathway in high-fat-diet-induced obese mice. Nutrients 2021; 13: 796.","DOI":"10.3390\/nu13030796"},{"key":"75115","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.3390\/nu13030796","DOI":"10.3390\/nu13030796"},{"key":"75116","doi-asserted-by":"crossref","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews BMJ 2021; 372: n71.","DOI":"10.1136\/bmj.n71"},{"key":"75117","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1136\/bmj.n71","DOI":"10.1136\/bmj.n71"}],"container-title":["Acta Dermato-Venereologica"],"original-title":[],"link":[{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/download\/40321\/47634","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/download\/40321\/47634","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T12:21:32Z","timestamp":1725970892000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/view\/40321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,10]]},"references-count":76,"URL":"https:\/\/doi.org\/10.2340\/actadv.v104.40321","relation":{},"ISSN":["1651-2057","0001-5555"],"issn-type":[{"value":"1651-2057","type":"electronic"},{"value":"0001-5555","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9,10]]}}}