{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:19:48Z","timestamp":1770682788910,"version":"3.49.0"},"reference-count":63,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Derm Venereol"],"abstract":"<jats:p>Sweet\u2019s syndrome (or acute febrile dermatosis) is a neutrophilic dermatosis with a characteristic presentation encompassing specific clinical (fever and erythemato-violaceous oedematous papules, plaques and nodules), laboratory (neutrophilia and increased inflammatory markers), and histological (dermal neutrophilic infiltrate without vasculitis) features. Its pathophysiology is poorly understood but there seems to be an auto-inflammatory component related to mutations in inflammasome genes. It has been subdivided into its classic form, malignancy-associated, and drug-induced, according to its aetiology. The condition usually responds rapidly to steroid therapy, but recurrences are common. This report presents an extremely rare case of hydroxychloroquine-induced Sweet\u2019s syndrome, plus a review of the literature, which encompasses 3 previous cases of Sweet\u2019s syndrome induced by hydroxychloroquine and 1 induced by chloroquine. Despite being relatively easy to diagnose, aetiological investigation poses challenges to the clinician, especially in the elderly population, as several confounding factors might be present. Further studies are necessary to shed light on the pathophysiology behind this entity, to further facilitate diagnostic workup and treatment strategies.<\/jats:p>","DOI":"10.2340\/actadv.v105.41333","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T05:53:31Z","timestamp":1736402011000},"page":"adv41333","source":"Crossref","is-referenced-by-count":4,"title":["Hydroxychloroquine-induced Sweet\u2019s Syndrome: A Case Report and Literature Review"],"prefix":"10.2340","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0669-5366","authenticated-orcid":false,"given":"Gustavo","family":"Almeida-Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0221-7193","authenticated-orcid":false,"given":"Joana","family":"Antunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4497-9763","authenticated-orcid":false,"given":"In\u00eas","family":"Tribolet de Abreu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9950-1521","authenticated-orcid":false,"given":"Filipe","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Vasconcelos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4026-6105","authenticated-orcid":false,"given":"Lu\u00eds","family":"Soares-Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo","family":"Filipe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1183","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"89739","doi-asserted-by":"crossref","unstructured":"Starita-Fajardo G, Lucena-L\u00f3pez D, Ballester-Mart\u00ednez MA, Fern\u00e1ndez-Guarino M, Gonz\u00e1lez-Garc\u00eda A, et al. Treatment strategies in neutrophilic dermatoses: a comprehensive review. Int J Mol Sci 2023; 24: 15622.","DOI":"10.3390\/ijms242115622"},{"key":"89740","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.3390\/ijms242115622","DOI":"10.3390\/ijms242115622"},{"key":"89741","doi-asserted-by":"crossref","unstructured":"Giasuddin AS, El-Orfi AH, Ziu MM, El-Barnawi NY. Sweet's syndrome: is the pathogenesis mediated by helper T cell type 1 cytokines? J Am Acad Dermatol 1998; 39: 940-943.","DOI":"10.1016\/S0190-9622(98)70266-X"},{"key":"89742","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1016\/S0190-9622(98)70266-X","DOI":"10.1016\/S0190-9622(98)70266-X"},{"key":"89743","doi-asserted-by":"crossref","unstructured":"Weiss EH, Ko CJ, Leung TH, Micheletti RG, Mostaghimi A, Ramachandran SM, et al. Neutrophilic dermatoses: a clinical update. 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