{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:18:39Z","timestamp":1780503519521,"version":"3.54.1"},"reference-count":56,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Derm Venereol"],"abstract":"<jats:p>This study investigates serum cell-free DNA fluctuations in patients with herpes zoster or post-herpetic neuralgia, offering insight into the tissue damage and inflammatory dynamics associated with these conditions. A single-centre combined cross-sectional and longitudinal study was conducted with 59 patients to assess cell-free DNA levels in herpes zoster and post-herpetic neuralgia. Cell-free DNA was extracted from blood samples of patients with herpes zoster or post-herpetic neuralgia and compared with healthy controls. The findings demonstrated elevated cell-free DNA levels in patients with herpes zoster, which remained elevated for 3 months or longer following treat-ment. These results suggest the presence of a subacute inflammatory state after herpes zoster infection. Furthermore, patients who developed post-herpetic neuralgia did not show elevated cell-free DNA levels, while those who did not develop post-herpetic neuralgia exhibited increased levels. This indicates that post-herpetic neuralgia is likely a localized response to prior nerve damage rather than a systemic inflammatory process with acute tissue damage.<\/jats:p>","DOI":"10.2340\/actadv.v105.42137","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T08:46:37Z","timestamp":1735893997000},"page":"adv42137","source":"Crossref","is-referenced-by-count":2,"title":["Cell-free DNA Levels in Herpes Zoster: A Cross-sectional Longitudi\u00adnal Study"],"prefix":"10.2340","volume":"105","author":[{"given":"Chaya Bracha","family":"Gordon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaron","family":"Zenaty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayelet","family":"Ollech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gidon","family":"Test","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amos","family":"Douvdevani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Horev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"89009","unstructured":"Apr2014_session6_herpes_zoster.pdf [Internet]. 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