{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:25:52Z","timestamp":1789683952380,"version":"4.0.1"},"reference-count":52,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Derm Venereol"],"abstract":"<jats:p>Atopic dermatitis (AD) is a chronic skin disease that significantly affects patients\u2019 quality of life. While other dermatological conditions like psoriasis are known to impact major life-changing decisions (MLCD), no prior studies have evaluated this in AD. A descriptive cross-sectional study was conducted in patients with AD of at least 6 months\u2019 duration. Sociodemographic and clinical characteristics of the patients, as well as severity from both the physician\u2019s and patient\u2019s point of view, were assessed using different rating scales such as the Eczema Area and Severity Index (EASI). Subsequently, patients were divided according to disease severity into severe AD (EASI \u2265\u200921) or mild\u2013moderate AD (EASI &lt;\u200921). Life decisions were evaluated across several areas, including work, education, social life, reproduction, recreation, housing, and lifestyle, using a 4-point Likert scale. A total of 104 patients, with an average disease duration of 20.36 years, were included. The results showed significant MLCD impairment, especially in clothing choices (52.9%), lifestyle (48.1%), and sports activities (41.4%). Severe AD was associated with greater social and emotional challenges, such as difficulties in social interactions (48.6% vs 26.1%) and romantic relationships (48.5% vs 18.8%) compared with mild\u2013moderate AD. These findings highlight the profound impact of AD on daily life, emphasizing the need for comprehensive management strategies that address physical, psychological, and social aspects.<\/jats:p>","DOI":"10.2340\/actadv.v105.42241","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T06:42:23Z","timestamp":1743576143000},"page":"adv42241","source":"Crossref","is-referenced-by-count":8,"title":["Impact on Major Life-changing Decisions in Patients with Atopic Dermatitis"],"prefix":"10.2340","volume":"105","author":[{"given":"Lucia","family":"Fuentes-Barrag\u00e1n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Garc\u00eda-Moronta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Sanabria-de la Torre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Le\u00f3n-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Molina-Leyva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Arias-Santiago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trinidad","family":"Montero-V\u00edlchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"105539","doi-asserted-by":"crossref","unstructured":"Nutten S. 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Patient perspectives on triggers, adherence to medical recommendations, and disease control in atopic dermatitis: the DATOP Study. Actas Dermosifiliogr 2014; 105: 487\u2013496.","DOI":"10.1016\/j.adengl.2014.04.012"},{"key":"105544","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1016\/j.ad.2014.01.004","DOI":"10.1016\/j.ad.2014.01.004"},{"key":"105545","doi-asserted-by":"crossref","unstructured":"Bylund S, Kobyletzki L, Svalstedt M, Svensson. Prevalence and incidence of atopic dermatitis: a systematic review. Acta Derm Venereol 2020; 100: adv00160.","DOI":"10.2340\/00015555-3510"},{"key":"105546","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.2340\/00015555-3510","DOI":"10.2340\/00015555-3510"},{"key":"105547","doi-asserted-by":"crossref","unstructured":"Margolis JS, Abuabara K, Bilker W, Hoffstad O, Margolis DJ. Persistence of mild to moderate atopic dermatitis. JAMA Dermatol 2014; 150: 593\u2013595.","DOI":"10.1001\/jamadermatol.2013.10271"},{"key":"105548","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1001\/jamadermatol.2013.10271","DOI":"10.1001\/jamadermatol.2013.10271"},{"key":"105549","doi-asserted-by":"crossref","unstructured":"Ali F, Vyas J, Finlay A. Counting the burden: atopic dermatitis and health-related quality of life. Acta Derm Venereol 2020; 100: adv00161.","DOI":"10.2340\/00015555-3511"},{"key":"105550","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.2340\/00015555-3511","DOI":"10.2340\/00015555-3511"},{"key":"105551","doi-asserted-by":"crossref","unstructured":"Bhatti Z, Salek M, Finlay A. Chronic diseases influence major life changing decisions: a new domain in quality of life research. 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