{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:08:15Z","timestamp":1791083295250,"version":"4.1.0"},"reference-count":79,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Derm Venereol"],"abstract":"<jats:p>Atopic dermatitis is a chronic inflammatory skin disease characterized by flare-ups of inflamed, dry, and itchy skin affecting over 200 million people worldwide. \u201cEmollients plus\u201d containing active cosmetic ingredients such as herbal extracts and phytochemicals have the potential to surpass the efficacy of conventional emollients, while avoiding side effects associated with pharmacological interventions. The reported 12-week clinical trial (NCT05790083) evaluated long-term efficacy and tolerability of oil-in-water emulsions BNO 3731 and BNO 3732 containing ginger extract and cannabidiol as basic emollient therapy for atopic dermatitis. A total of 100 adults and children with a history of atopic dermatitis were included and applied BNO 3732 (body lotion) twice daily and BNO 3731 (intensive care product) as needed. Over 12 weeks the emollients plus combination led to sustained improvement of peak pruritus and patient-reported outcome measures, i.e., \u201cRecap of atopic eczema\u201d. Objective dermatological evaluation showed progressive improvements for vIGA-ADTM and isolated symptoms, i.e., erythema and dryness. Instrumental analysis of intercellular lipid contents and lipid lamellae organization in the stratum corneum demonstrated recovery of the epidermal barrier integrity. The clinical results provide evidence on the efficacy of herbal emollients plus beyond mere moisturizing and occlusive properties. BNO 3731 and BNO 3732 were very well tolerated.<\/jats:p>","DOI":"10.2340\/actadv.v105.43026","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T06:17:11Z","timestamp":1750313831000},"page":"adv43026","source":"Crossref","is-referenced-by-count":5,"title":["Long-term Progressive Improvement of Atopic Dermatitis by an Herbal Emollient Plus Combination in a 12-week Clinical Trial"],"prefix":"10.2340","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9206-2115","authenticated-orcid":false,"given":"Lars","family":"Herrmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7098-4445","authenticated-orcid":false,"given":"Stanislav","family":"Andreev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramona","family":"Ziegler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Neubauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Moritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Maehler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Steindl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Daehnhardt-Pfeiffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7778-7740","authenticated-orcid":false,"given":"Christoph","family":"Abels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"115524","doi-asserted-by":"crossref","unstructured":"Tian J, Zhang D, Yang Y, Huang Y, Wang L, Yao X, et al. Global epidemiology of atopic dermatitis: a comprehensive systematic analysis and modelling study. Br J Dermatol 2024; 190: 55\u201361.","DOI":"10.1093\/bjd\/ljad339"},{"key":"115525","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1093\/bjd\/ljad339","DOI":"10.1093\/bjd\/ljad339"},{"key":"115526","doi-asserted-by":"crossref","unstructured":"Saeki H, Ohya Y, Furuta J, Arakawa H, Ichiyama S, Katsunuma T, et al. English version of Clinical Practice Guidelines for the Management of Atopic Dermatitis 2021. J Dermatol 2022; 49: e315\u2013e375.","DOI":"10.1111\/1346-8138.16527"},{"key":"115527","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/1346-8138.16527","DOI":"10.1111\/1346-8138.16527"},{"key":"115528","doi-asserted-by":"crossref","unstructured":"Silverberg JI, Mohawk JA, Cirulli J, Nograles K, Punzalan JC, Kelly KM, et al. Burden of disease and unmet needs in atopic dermatitis: results from a patient survey. Dermatitis 2023; 34: 135\u2013144.","DOI":"10.1089\/derm.2022.29015.jsi"},{"key":"115529","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1089\/derm.2022.29015.jsi","DOI":"10.1089\/derm.2022.29015.jsi"},{"key":"115530","doi-asserted-by":"crossref","unstructured":"Yosipovitch G, Misery L, Proksch E, Metz M, St\u00e4nder S, Schmelz M. Skin barrier damage and itch: review of mechanisms, topical management and future directions. Acta Derm Venereol 2019; 99: 1201\u20131209.","DOI":"10.2340\/00015555-3296"},{"key":"115531","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.2340\/00015555-3296","DOI":"10.2340\/00015555-3296"},{"key":"115532","doi-asserted-by":"crossref","unstructured":"F\u00f6lster-Holst R, Reimer R, Neumann C, Proksch E, Rodriguez E, Weidinger S, et al. Comparison of epidermal barrier integrity in adults with classic atopic dermatitis, atopic prurigo and non-atopic prurigo nodularis. Biology 2021; 10: 1008.","DOI":"10.3390\/biology10101008"},{"key":"115533","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.3390\/biology10101008","DOI":"10.3390\/biology10101008"},{"key":"115534","doi-asserted-by":"crossref","unstructured":"Fujii M. The pathogenic and therapeutic implications of ceramide abnormalities in atopic dermatitis. Cells 2021; 10: 2386.","DOI":"10.3390\/cells10092386"},{"key":"115535","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.3390\/cells10092386","DOI":"10.3390\/cells10092386"},{"key":"115536","doi-asserted-by":"crossref","unstructured":"Daehnhardt-Pfeiffer S, Surber C, Wilhelm KP, Daehnhardt D, Springmann G, Boettcher M, et al. Noninvasive stratum corneum sampling and electron microscopical examination of skin barrier integrity: pilot study with a topical glycerin formulation for atopic dermatitis. Skin Pharmacol Physiol 2012; 25: 155\u2013161.","DOI":"10.1159\/000336789"},{"key":"115537","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1159\/000336789","DOI":"10.1159\/000336789"},{"key":"115538","doi-asserted-by":"crossref","unstructured":"D\u00e4hnhardt D, Surber C, D\u00e4hnhardt-Pfeiffer S. Influence of topical formulations: lipid lamella organization and lipid composition of stratum corneum as a surrogate marker for barrier integrity. pH of the skin: issues and challenges. Basel: Karger AG, 2018: p. 166\u2013172.","DOI":"10.1159\/000489530"},{"key":"115539","doi-asserted-by":"crossref","unstructured":"Blaak J, D\u00e4hnhardt D, Bielfeldt S, Theiss C, Simon I, Wilhelm K-P, et al. Improvement of human epidermal barrier structure and lipid profile in xerotic- and atopic-prone skin via application of a plant-oil and urea containing pH 4.5 emulsion. Cosmetics 2023; 10: 95.","DOI":"10.3390\/cosmetics10040095"},{"key":"115540","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.3390\/cosmetics10040095","DOI":"10.3390\/cosmetics10040095"},{"key":"115541","doi-asserted-by":"crossref","unstructured":"Ol\u00e1h A, Szab\u00f3-Papp J, Soeberdt M, Knie U, D\u00e4hnhardt-Pfeiffer S, Abels C, et al. Echinacea purpurea-derived alkylamides exhibit potent anti-inflammatory effects and alleviate clinical symptoms of atopic eczema. J Dermatol Sci 2017; 88: 67\u201377.","DOI":"10.1016\/j.jdermsci.2017.05.015"},{"key":"115542","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1016\/j.jdermsci.2017.05.015","DOI":"10.1016\/j.jdermsci.2017.05.015"},{"key":"115543","doi-asserted-by":"crossref","unstructured":"Hirao T, Terui T, Takeuchi I, Kobayashi H, Okada M, Takahashi M, et al. Ratio of immature cornified envelopes does not correlate with parakeratosis in inflammatory skin disorders. Exp Dermatol 2003; 12: 591\u2013601.","DOI":"10.1034\/j.1600-0625.2003.00007.x"},{"key":"115544","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1034\/j.1600-0625.2003.00007.x","DOI":"10.1034\/j.1600-0625.2003.00007.x"},{"key":"115545","doi-asserted-by":"crossref","unstructured":"Araviiskaia E, Pincelli C, Sparavigna A, Luger T. The role of a novel generation of emollients, \u2018emollients plus\u2019, in atopic dermatitis. Clin Cosmet Investig Dermatol 2022; 15: 2705\u20132719.","DOI":"10.2147\/CCID.S389697"},{"key":"115546","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.2147\/CCID.S389697","DOI":"10.2147\/CCID.S389697"},{"key":"115547","doi-asserted-by":"crossref","unstructured":"Wollenberg A, Kinberger M, Arents B, Aszodi N, Avila Valle G, Barbarot S, et al. European guideline (EuroGuiDerm) on atopic eczema \u2013 part II: non-systemic treatments and treatment recommendations for special AE patient populations. J Eur Acad Dermatol Venereol 2022; 36: 1904\u20131926.","DOI":"10.1111\/jdv.18429"},{"key":"115548","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/jdv.18429","DOI":"10.1111\/jdv.18429"},{"key":"115549","unstructured":"European Federation of Allergy and Airways Diseases Patients\u2019 Associations. The burden of atopic eczema. European consensus report 2022. 2022 [last accessed 24 September 2024]. Available from: https:\/\/www.efanet.org\/inform\/patient-evidence\/atopic-eczema-consensus-europe\/report"},{"key":"115550","doi-asserted-by":"crossref","unstructured":"Arora P, Shiveena B, Garg M, Kumari S, Goyal A. Curative potency of medicinal plants in management of eczema: a conservative approach. Phytomedicine Plus 2022; 2: 100256.","DOI":"10.1016\/j.phyplu.2022.100256"},{"key":"115551","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1016\/j.phyplu.2022.100256","DOI":"10.1016\/j.phyplu.2022.100256"},{"key":"115552","doi-asserted-by":"crossref","unstructured":"Angelova-Fischer I, Rippke F, Richter D, Filbry A, Arrowitz C, Weber T, et al. Stand-alone emollient treatment reduces flares after discontinuation of topical steroid treatment in atopic dermatitis: a double-blind, randomized, vehicle-controlled, left\u2013right comparison study. Acta Derm Venereol 2018; 98: 517\u2013523.","DOI":"10.2340\/00015555-2882"},{"key":"115553","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.2340\/00015555-2882","DOI":"10.2340\/00015555-2882"},{"key":"115554","doi-asserted-by":"crossref","unstructured":"Neubauer C, Kragl M, Braun T, Filipek P, Rad EB, Grander J, et al. An oil-in-water emulsion containing a combination of ginger extract and synthetic cannabidiol with potent in vitro anti-inflammatory effects ameliorates symptoms of atopic dermatitis in a clinical trial. Eur J Dermatol 2024; 34: 416\u2013424.","DOI":"10.1684\/ejd.2024.4738"},{"key":"115555","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1684\/ejd.2024.4738","DOI":"10.1684\/ejd.2024.4738"},{"key":"115556","doi-asserted-by":"crossref","unstructured":"Blicharz L, Rudnicka L, Czuwara J, Wa\u015bkiel-Burnat A, Goldust M, Olszewska M, et al. The influence of microbiome dysbiosis and bacterial biofilms on epidermal barrier function in atopic dermatitis: an update. Int J Mol Sci 2021; 22: 8403.","DOI":"10.3390\/ijms22168403"},{"key":"115557","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.3390\/ijms22168403","DOI":"10.3390\/ijms22168403"},{"key":"115558","doi-asserted-by":"crossref","unstructured":"Andreev S, Neubauer C, M\u00e4hler N, Moritz K, Ziegler R, Apfelbacher C, et al. 50th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF): Therapeutic effects and impact of individual skin care regimes as basic therapy in the management of atopic dermatitis: a remote prospective observational study in adults and children suffering from AD. Exp Dermatol 2024; 33: e14994, P14059.","DOI":"10.1111\/exd.14994"},{"key":"115559","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/exd.14994","DOI":"10.1111\/exd.14994"},{"key":"115560","doi-asserted-by":"crossref","unstructured":"Howells LM, Chalmers JR, Gran S, Ahmed A, Apfelbacher C, Burton T, et al. Development and initial testing of a new instrument to measure the experience of eczema control in adults and children: recap of atopic eczema (RECAP). Br J Dermatol 2020; 183: 524\u2013536.","DOI":"10.1111\/bjd.18780"},{"key":"115561","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/bjd.18780","DOI":"10.1111\/bjd.18780"},{"key":"115562","doi-asserted-by":"crossref","unstructured":"Basra MKA, Fenech R, Gatt RM, Salek MS, Finlay AY. The Dermatology Life Quality Index 1994\u20132007: a comprehensive review of validation data and clinical results. Br J Dermatol 2008; 159: 997\u20131035.","DOI":"10.1111\/j.1365-2133.2008.08832.x"},{"key":"115563","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/j.1365-2133.2008.08832.x","DOI":"10.1111\/j.1365-2133.2008.08832.x"},{"key":"115564","doi-asserted-by":"crossref","unstructured":"Lewis-Jones MS, Finlay AY. The Children\u2019s Dermatology Life Quality Index (CDLQI): initial validation and practical use. Br J Dermatol 1995; 132: 942\u2013949.","DOI":"10.1111\/j.1365-2133.1995.tb16953.x"},{"key":"115565","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/j.1365-2133.1995.tb16953.x","DOI":"10.1111\/j.1365-2133.1995.tb16953.x"},{"key":"115566","doi-asserted-by":"crossref","unstructured":"Lewis-Jones MS, Finlay AY, Dykes PJ. The Infants\u2019 Dermatitis Quality of Life Index. Br J Dermatol 2001; 144: 104\u2013110.","DOI":"10.1046\/j.1365-2133.2001.03960.x"},{"key":"115567","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1046\/j.1365-2133.2001.03960.x","DOI":"10.1046\/j.1365-2133.2001.03960.x"},{"key":"115568","doi-asserted-by":"crossref","unstructured":"Yosipovitch G, Reaney M, Mastey V, Eckert L, Abb\u00e9 A, Nelson L, et al. Peak Pruritus Numerical Rating Scale: psychometric validation and responder definition for assessing itch in moderate-to-severe atopic dermatitis. Br J Dermatol 2019; 181: 761\u2013769.","DOI":"10.1111\/bjd.17744"},{"key":"115569","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/bjd.17744","DOI":"10.1111\/bjd.17744"},{"key":"115570","doi-asserted-by":"crossref","unstructured":"Thomas KS, Apfelbacher CA, Chalmers JR, Simpson E, Spuls PI, Gerbens LAA, et al. Recommended core outcome instruments for health-related quality of life, long-term control and itch intensity in atopic eczema trials: results of the HOME VII consensus meeting. Br J Dermatol 2021; 185: 139\u2013146.","DOI":"10.1111\/bjd.19751"},{"key":"115571","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/bjd.19751","DOI":"10.1111\/bjd.19751"},{"key":"115572","doi-asserted-by":"crossref","unstructured":"Simpson EL, Bissonnette R, Paller AS, King B, Silverberg JI, Reich K, et al. The Validated Investigator Global Assessment for Atopic Dermatitis (vIGA-AD\u2122): a clinical outcome measure for the severity of atopic dermatitis. Br J Dermatol 2022; 187: 531\u2013538.","DOI":"10.1111\/bjd.21615"},{"key":"115573","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/bjd.21615","DOI":"10.1111\/bjd.21615"},{"key":"115574","doi-asserted-by":"crossref","unstructured":"Hirao T, Denda M, Takahashi M. Identification of immature cornified envelopes in the barrier-impaired epidermis by characterization of their hydrophobicity and antigenicities of the components. Exp Dermatol 2001; 10: 35\u201344.","DOI":"10.1034\/j.1600-0625.2001.100105.x"},{"key":"115575","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1034\/j.1600-0625.2001.100105.x","DOI":"10.1034\/j.1600-0625.2001.100105.x"},{"key":"115576","unstructured":"R Core Team (2022). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL https:\/\/www.R-project.org\/."},{"key":"115577","doi-asserted-by":"crossref","unstructured":"Bhanot A, Peters TJ, Ridd MJ. Assessing the validity, responsiveness and reliability of the Recap measure of eczema control. Br J Dermatol 2021; 184: 955\u2013957.","DOI":"10.1111\/bjd.19709"},{"key":"115578","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/bjd.19709","DOI":"10.1111\/bjd.19709"},{"key":"115579","doi-asserted-by":"crossref","unstructured":"Zhang J, Ragamin A, Romeijn GLE, Loman L, Oosterhaven JAF, Schuttelaar MLA. Validity, reliability, responsiveness and interpretability of the Recap of atopic eczema (RECAP) questionnaire. Br J Dermatol 2023; 189: 578\u2013587.","DOI":"10.1093\/bjd\/ljad247"},{"key":"115580","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1093\/bjd\/ljad247","DOI":"10.1093\/bjd\/ljad247"},{"key":"115581","doi-asserted-by":"crossref","unstructured":"Hongbo Y, Thomas CL, Harrison MA, Sam Salek M, Finlay AY. Translating the science of quality of life into practice: what do dermatology life quality index scores mean? J Invest Dermatol 2005; 125: 659\u2013664.","DOI":"10.1111\/j.0022-202X.2005.23621.x"},{"key":"115582","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/j.0022-202X.2005.23621.x","DOI":"10.1111\/j.0022-202X.2005.23621.x"},{"key":"115583","unstructured":"Waters A, Sandhu D, Beattie P, Ezughah F, Lewis-Jones S. PA-8: Severity stratification of Children\u2019s Dermatology Life Quality Index (CDLQI) scores. Br J Dermatol 2010; 163: 118\u2013130."},{"key":"115584","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/j.1365-2133.2010.09733.x","DOI":"10.1111\/j.1365-2133.2010.09733.x"},{"key":"115585","doi-asserted-by":"crossref","unstructured":"Kottner J, Lichterfeld A, Blume-Peytavi U. Transepidermal water loss in young and aged healthy humans: a systematic review and meta-analysis. Arch Dermatol Res 2013; 305: 315\u2013323.","DOI":"10.1007\/s00403-012-1313-6"},{"key":"115586","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1007\/s00403-012-1313-6","DOI":"10.1007\/s00403-012-1313-6"},{"key":"115587","doi-asserted-by":"crossref","unstructured":"Akdeniz M, Gabriel S, Lichterfeld-Kottner A, Blume-Peytavi U, Kottner J. Transepidermal water loss in healthy adults: a systematic review and meta-analysis update. Br J Dermatol 2018; 179: 1049\u20131055.","DOI":"10.1111\/bjd.17025"},{"key":"115588","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/bjd.17025","DOI":"10.1111\/bjd.17025"},{"key":"115589","doi-asserted-by":"crossref","unstructured":"Boer M, Duchnik E, Maleszka R, Marchlewicz M. Structural and biophysical characteristics of human skin in maintaining proper epidermal barrier function. Adv Dermatol Allergol 2016; 1: 1\u20135.","DOI":"10.5114\/pdia.2015.48037"},{"key":"115590","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.5114\/pdia.2015.48037","DOI":"10.5114\/pdia.2015.48037"},{"key":"115591","doi-asserted-by":"crossref","unstructured":"Quadri M, Lotti R, Bonzano L, Ciardo S, Guanti MB, Pellacani G, et al. A novel multi-action emollient plus cream improves skin barrier function in patients with atopic dermatitis: in vitro and clinical evidence. Skin Pharmacol Physiol 2021; 34: 8\u201318.","DOI":"10.1159\/000513055"},{"key":"115592","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1159\/000513055","DOI":"10.1159\/000513055"},{"key":"115593","doi-asserted-by":"crossref","unstructured":"Magnolo N, Jaenicke T, Tsianakas A, Czech W, Tha\u00e7i D, Pinter A, et al. Comparison of different skin care regimens in patients with moderate to severe atopic dermatitis receiving systemic treatment: a randomized controlled trial. J Eur Acad Dermatol Venereol 2023; 37: 18\u201326.","DOI":"10.1111\/jdv.18949"},{"key":"115594","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/jdv.18949","DOI":"10.1111\/jdv.18949"},{"key":"115595","doi-asserted-by":"crossref","unstructured":"Bouwstra JA, N\u0103d\u0103ban A, Bras W, McAbe C, Bunge A, Gooris GS. The skin barrier: an extraordinary interface with an exceptional lipid organization. Prog Lipid Res 2023; 92: 101252.","DOI":"10.1016\/j.plipres.2023.101252"},{"key":"115596","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1016\/j.plipres.2023.101252","DOI":"10.1016\/j.plipres.2023.101252"},{"key":"115597","doi-asserted-by":"crossref","unstructured":"Murphy B, Grimshaw S, Hoptroff M, Paterson S, Arnold D, Cawley A, et al. Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin. Sci Rep 2022; 12: 5223.","DOI":"10.1038\/s41598-022-09231-8"},{"key":"115598","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1038\/s41598-022-09231-8","DOI":"10.1038\/s41598-022-09231-8"},{"key":"115599","doi-asserted-by":"crossref","unstructured":"Tier HL, Balogh EA, Bashyam AM, Fleischer AB, Spergel JM, Masicampo EJ, et al. Tolerability of and adherence to topical treatments in atopic dermatitis: a narrative review. Dermatol Ther 2021; 11: 415\u2013431.","DOI":"10.1007\/s13555-021-00500-4"},{"key":"115600","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1007\/s13555-021-00500-4","DOI":"10.1007\/s13555-021-00500-4"},{"key":"115601","doi-asserted-by":"crossref","unstructured":"Maleki-Yazdi KA, Heen AF, Zhao IX, Guyatt GH, Suzumura EA, Makhdami N, et al. Values and preferences of patients and caregivers regarding treatment of atopic dermatitis (eczema): a systematic review. JAMA Dermatology 2023; 159: 320\u2013330.","DOI":"10.1001\/jamadermatol.2022.6045"},{"key":"115602","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1001\/jamadermatol.2022.6045","DOI":"10.1001\/jamadermatol.2022.6045"}],"container-title":["Acta Dermato-Venereologica"],"original-title":[],"link":[{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/download\/43026\/50513","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/download\/43026\/50513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T06:17:32Z","timestamp":1750313852000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/view\/43026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,18]]},"references-count":79,"URL":"https:\/\/doi.org\/10.2340\/actadv.v105.43026","relation":{},"ISSN":["1651-2057","0001-5555"],"issn-type":[{"value":"1651-2057","type":"electronic"},{"value":"0001-5555","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,18]]}}}