{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:19:05Z","timestamp":1787660345466,"version":"build-2736575974"},"reference-count":41,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Derm Venereol"],"abstract":"<jats:p>Neurofibromatosis type 1 (NF1) affects multiple organs progressively, leading to a shortened life expectancy. This study aimed to identify the complications that are prominent in each age group by comparing 28,082 patients with NF1 and 84,246 matched controls. Benign and malignant neoplasms along with neurological complications were the primary contributors to hospital use across most age groups. Respiratory and circulatory disorders were a common cause of hospital use in children and older adults, respectively. Except for soft tissue and central nervous system-originated malignancies, which are well-established NF1-related tumours, the highest rate ratios (RR) of malignancies with statistical significance was observed in the adrenal gland (0\u20139 years, RR 50.67, 95% CI 6.74\u2013380.76); female genital organs (10\u201314 years, RR 12.06, 95% CI 1.35\u2013107.93); respiratory and intrathoracic organs (15\u201319 years, RR 15.10, 95% CI 1.76\u2013129.22; 20\u201329 years, RR 7.59, 95% CI 2.94\u201319.56; \u2265 60 years, RR 1.38, 95% CI 1.18\u20131.61); lip, oral cavity, and pharynx (30\u201339 years, RR 6.11, 95% CI 1.53\u201324.42); and bone and articular cartilage (40\u201349 years, RR 3.06, 95% CI 1.37\u20136.81; 50\u201359 years, RR 4.73, 95% CI 2.35\u20139.50). Comorbidities and malignancies that predominantly affect patients vary by age group; physicians should be aware of the appropriate management strategies throughout their lifespan.<\/jats:p>","DOI":"10.2340\/actadv.v105.43416","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T11:40:34Z","timestamp":1750851634000},"page":"adv43416","source":"Crossref","is-referenced-by-count":3,"title":["Hospital Use, Morbidity, and Cancer Risk by Age Group in Neurofibromatosis Type 1: A Nationwide Retrospective Cohort Study"],"prefix":"10.2340","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0590-7894","authenticated-orcid":false,"given":"Minsu","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8560-5002","authenticated-orcid":false,"given":"Suhyun","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9994-8819","authenticated-orcid":false,"given":"Chong Won","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2223-1606","authenticated-orcid":false,"given":"Bo Ri","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5602-3530","authenticated-orcid":false,"given":"Sang Woong","family":"Youn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"116015","doi-asserted-by":"crossref","unstructured":"Gutmann DH, Ferner RE, Listernick RH, Korf BR, Wolters PL, Johnson KJ. 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Young Australian adults with NF1 have poor access to health care, high complication rates, and limited disease knowledge. Am J Med Genet A 2013; 161A: 659\u2013666.","DOI":"10.1002\/ajmg.a.35840"},{"key":"116020","doi-asserted-by":"crossref","unstructured":"Kokkinou E, Roka K, Alexopoulos A, Tsina E, Nikas I, Krallis P, et al. Development of a multidisciplinary clinic of neurofibromatosis type 1 and other neurocutaneous disorders in Greece: a 3-year experience. Postgrad Med 2019; 131: 445\u2013452.","DOI":"10.1080\/00325481.2019.1659708"},{"key":"116021","doi-asserted-by":"crossref","unstructured":"Zoller M, Rembeck B, Akesson HO, Angervall L. Life expectancy, mortality and prognostic factors in neurofibromatosis type 1: a twelve-year follow-up of an epidemiological study in Goteborg, Sweden. Acta Derm Venereol 1995; 75: 136\u2013140.","DOI":"10.2340\/0001555575136140"},{"key":"116022","doi-asserted-by":"crossref","unstructured":"Rasmussen SA, Yang Q, Friedman JM. Mortality in neurofibromatosis 1: an analysis using U.S. death certificates. Am J Hum Genet 2001; 68: 1110\u20131118.","DOI":"10.1086\/320121"},{"key":"116023","doi-asserted-by":"crossref","unstructured":"Duong TA, Sbidian E, Valeyrie-Allanore L, Vialette C, Ferkal S, Hadj-Rabia S, et al. Mortality associated with neurofibromatosis 1: a cohort study of 1895 patients in 1980\u20132006 in France. Orphanet J Rare Dis 2011; 6: 18.","DOI":"10.1186\/1750-1172-6-18"},{"key":"116024","doi-asserted-by":"crossref","unstructured":"Uusitalo E, Leppavirta J, Koffert A, Suominen S, Vahtera J, Vahlberg T, et al. Incidence and mortality of neurofibromatosis: a total population study in Finland. J Invest Dermatol 2015; 135: 904\u2013906.","DOI":"10.1038\/jid.2014.465"},{"key":"116025","doi-asserted-by":"crossref","unstructured":"Kenborg L, Duun-Henriksen AK, Dalton SO, Bidstrup PE, Doser K, Rugbjerg K, et al. 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Children (Basel) 2023; 10: 330.","DOI":"10.3390\/children10020330"},{"key":"116035","doi-asserted-by":"crossref","unstructured":"Kallionpaa RA, Valtanen M, Auranen K, Uusitalo E, Rinne JO, Peltonen S, et al. Increased risk for dementia in neurofibromatosis type 1. Genet Med 2021; 23: 2219\u20132222.","DOI":"10.1038\/s41436-021-01261-3"},{"key":"116036","doi-asserted-by":"crossref","unstructured":"Kenborg L, Andersen EW, Duun-Henriksen AK, Jepsen JRM, Doser K, Dalton SO, et al. Psychiatric disorders in individuals with neurofibromatosis 1 in Denmark: a nationwide register-based cohort study. Am J Med Genet A 2021; 185: 3706\u20133716.","DOI":"10.1002\/ajmg.a.62436"},{"key":"116037","doi-asserted-by":"crossref","unstructured":"Reviron-Rabec L, Girerd B, Seferian A, Campbell K, Brosseau S, Bergot E, et al. Pulmonary complications of type 1 neurofibromatosis. 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