{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:52:40Z","timestamp":1788191560959,"version":"build-2803163510"},"reference-count":24,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Derm Venereol"],"abstract":"<jats:p>Real-world data on the drug survival of established and emerging treatment options in atopic dermatitis provide a comprehensive measure of the efficacy and tolerability of these interventions, which may enable improvements in clinical management. This study aimed to describe the drug survival, with associated predictors, of treatment with abrocitinib, baricitinib, cyclosporine, dupilumab, methotrexate, tralokinumab, and upadacitinib among patients with atopic dermatitis in Sweden who were recruited into the multicentre prospective SwedAD cohort between January 2017 and April 2024. A total of 1,194 patients were included with a total of 1,486 treatment episodes. The 2-year drug survival probability was 14.2% for baricitinib (treatment episodes, n\u2009=\u200930), 12.2% for cyclosporine (n\u2009=\u200940), 79.7% for dupilumab (n\u2009=\u20091,026), 45.4% for methotrexate (n\u2009=\u2009260), and 46.0% for upadacitinib (n\u2009=\u200989). Two-year follow-up data were not available for abrocitinib (n\u2009=\u200923) or tralokinumab (n\u2009=\u200918). All drugs were compared with the most used conventional systemic treatment at study baseline, methotrexate, using Cox regression. Only dupilumab showed a significantly lower hazard rate of drug discontinuation. In conclusion, dupilumab therapy demonstrated longer drug survival than methotrexate in atopic dermatitis. The impact of national treatment guidelines and time since drug approval should be considered when interpreting the results.<\/jats:p>","DOI":"10.2340\/actadv.v105.43464","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T10:23:45Z","timestamp":1754562225000},"page":"adv43464","source":"Crossref","is-referenced-by-count":10,"title":["Drug Survival and Predictors of Systemic Treatment Outcome in Atopic Dermatitis: Data From a Nationwide Swedish Cohort"],"prefix":"10.2340","volume":"105","author":[{"given":"Pontus O.","family":"Jonsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Tayefi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Svedbom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma K.","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"120027","doi-asserted-by":"crossref","unstructured":"Langan SM, Irvine AD, Weidinger S. Atopic dermatitis. Lancet 2020; 396: 345\u2013360.","DOI":"10.1016\/S0140-6736(20)31286-1"},{"key":"120028","doi-asserted-by":"crossref","unstructured":"G\u00e5nemo A, Svensson A, Lindberg M, Wahlgren CF. Quality of life in Swedish children with eczema. Acta Derm Venereol 2007; 87: 345\u2013349.","DOI":"10.2340\/00015555-0245"},{"key":"120029","doi-asserted-by":"crossref","unstructured":"Bylund S, Kobyletzki LB, Svalstedt M, Svensson \u00c5. Prevalence and incidence of atopic dermatitis: a systematic review. Acta Derm Venereol 2020; 100: adv00160.","DOI":"10.2340\/00015555-3510"},{"key":"120030","doi-asserted-by":"crossref","unstructured":"Tian J, Zhang D, Yang Y, Huang Y, Wang L, Yao X, et al. Global epidemiology of atopic dermatitis: a comprehensive systematic analysis and modelling study. Br J Dermatol 2023; 190: 55\u201361.","DOI":"10.1093\/bjd\/ljad339"},{"key":"120031","doi-asserted-by":"crossref","unstructured":"Augustin M, Misery L, von Kobyletzki L, Armario-Hita JC, Mealing S, Redding M. Unveiling the true costs and societal impacts of moderate-to-severe atopic dermatitis in Europe. J Eur Acad Dermatol Venereol 2022; 36 Suppl 7: 3\u201316.","DOI":"10.1111\/jdv.18168"},{"key":"120032","doi-asserted-by":"crossref","unstructured":"Wollenberg A, Kinberger M, Arents B, Aszodi N, Avila Valle G, Barbarot S, et al. European guideline (EuroGuiDerm) on atopic eczema: part I \u2013 systemic therapy. J Eur Acad Dermatol Venereol 2022; 36: 1409\u20131431.","DOI":"10.1111\/jdv.18345"},{"key":"120033","doi-asserted-by":"crossref","unstructured":"Seegr\u00e4ber M, Srour J, Walter A, Knop M, Wollenberg A. Dupilumab for treatment of atopic dermatitis. Expert Rev Clin Pharmacol 2018; 11: 467\u2013474.","DOI":"10.1080\/17512433.2018.1449642"},{"key":"120034","doi-asserted-by":"crossref","unstructured":"Gooderham MJ, Hong HC, Eshtiaghi P, Papp KA. Dupilumab: a review of its use in the treatment of atopic dermatitis. J Am Acad Dermatol 2018; 78: S28\u2013S36.","DOI":"10.1016\/j.jaad.2017.12.022"},{"key":"120035","doi-asserted-by":"crossref","unstructured":"Popovic B, Breed J, Rees DG, Gardener MJ, Vinall LM, Kemp B, et al. Structural characterisation reveals mechanism of IL-13-neutralising monoclonal antibody tralokinumab as inhibition of binding to IL-13R\u03b11 and IL-13R\u03b12. J Mol Biol 2017; 429: 208\u2013219.","DOI":"10.1016\/j.jmb.2016.12.005"},{"key":"120036","doi-asserted-by":"crossref","unstructured":"Potestio L, Patruno C, Napolitano M. Efficacy and safety of tralokinumab in real life: possible predictive rapid response factors. Dermatitis 2024; 35: S77\u2013S80.","DOI":"10.1089\/derm.2023.0261"},{"key":"120037","doi-asserted-by":"crossref","unstructured":"van den Reek J, Kievit W, Gniadecki R, Goeman JJ, Zweegers J, van de Kerkhof PCM, et al. Drug survival studies in dermatology: principles, purposes, and pitfalls. J Invest Dermatol 2015; 135: 1\u20135.","DOI":"10.1038\/jid.2015.171"},{"key":"120038","doi-asserted-by":"crossref","unstructured":"Alsterholm M, Svedbom A, Anderson CD, Holm Sommar L, Ivert LU, Josefson A, et al. Establishment and utility of SwedAD: a nationwide Swedish Registry for patients with atopic dermatitis receiving systemic pharmacotherapy. Acta Derm Venereol 2023; 103: adv7312.","DOI":"10.2340\/actadv.v103.7312"},{"key":"120039","doi-asserted-by":"crossref","unstructured":"Schram ME, Spuls PI, Leeflang MM, Lindeboom R, Bos JD, Schmitt J. EASI (objective) SCORAD and POEM for atopic eczema: responsiveness and minimal clinically important difference. 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Treatment of atopic dermatitis: recently approved drugs and advanced clinical development programs. 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