{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:03:02Z","timestamp":1791270182446,"version":"4.1.0"},"reference-count":39,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Derm Venereol"],"abstract":"<jats:p>A study was undertaken to compare the effectiveness and adverse effects of non-insulated microneedle fractional radiofrequency (NIMFRF) and ablative fractional carbon dioxide (AFCO2) laser on facial atrophic acne scarring in a randomized split-face model. Thirty subjects with facial atrophic acne scarring were enrolled. Each side of the face randomly received 1 session of NIMFRF or AFCO2 laser. Photographs were taken by VISIA Complexion Analysis System at baseline, 1 month, 2 months, and 6 months after treatments. Subjective evaluations included \u00c9chelle d\u2019\u00c9valuation Clinique des Cicatrices d\u2019Acn\u00e9 (ECCA) score, global improve-ment, and self-satisfaction. Potential adverse effects were also recorded. Skin melanin index and ery-thema index were measured. NIMFRF and AFCO2 laser show-ed comparable efficacies on atrophic acne scarring (p\u2009&gt;\u20090.05). ECCA scores decreased significantly at each follow-up visit, compared with baseline (p\u2009&lt;\u20090.05). Approximate 95% of subjects achieved \u201csatisfied\u201d or \u201cvery satisfied\u201d improvement. Pain was more obvious on the AFCO2 laser side. Significantly increased red area value, melanin index and erythema index levels were seen on the AFCO2 laser side at one month or 2 month, compared with the NIMFRF side (p\u2009&lt;\u20090.05). NIMFRF has milder adverse effects with shorter recovery period than AFCO2 laser. NIMFRF may be preferable for some patients due to its favourable adverse effect profile.<\/jats:p>","DOI":"10.2340\/actadv.v105.43611","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T11:33:19Z","timestamp":1750937599000},"page":"adv43611","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of Non-insulated Microneedle Fractional Radiofrequency and Ablative Fractional Carbon Dioxide Laser for the Treatment of Facial Atrophic Acne Scarring: A Pilot Randomized Split-face Clinical Study"],"prefix":"10.2340","volume":"105","author":[{"given":"Le","family":"Qu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Sha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chundi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Duo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"116542","doi-asserted-by":"crossref","unstructured":"Cohen BE, Brauer JA, Geronemus RG. 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Dermatol Res Pract 2010; 2010: 893080.","DOI":"10.1155\/2010\/893080"},{"key":"116546","doi-asserted-by":"crossref","unstructured":"El-Hawary EE, Nassar S, Hodeib AA, Shareef MM, Fawzy MM. Ablative fractional carbon dioxide laser and autologous platelet-rich plasma in the treatment of atrophic acne scars: a comparative clinico-immuno-histopathological study. Lasers Surg Med 2021; 53: 458\u2013467.","DOI":"10.1002\/lsm.23306"},{"key":"116547","doi-asserted-by":"crossref","unstructured":"Lee SR, Cho S. Clinical factors affecting the effectiveness of 1550-nm erbium-doped fractional photothermolysis laser for individual atrophic acne scar types. Dermatol Ther (Heidelb) 2023; 13: 609\u2013616.","DOI":"10.1007\/s13555-022-00887-8"},{"key":"116548","unstructured":"Agrawal K, Belgaumkar VA, Chavan RB, Pradhan SN. Evaluating the pros and cons of fractional CO2 laser versus microneedling in atrophic acne scars in the skin of color: a split face study. Indian Dermatol Online J 2024; 15: 942\u2013948."},{"key":"116549","doi-asserted-by":"crossref","unstructured":"Kwon HH, Park HY, Choi SC, Bae Y, Kang C, Jung JY, et al. Combined fractional treatment of acne scars involving non-ablative 1,550-nm erbium-glass laser and micro-needling radiofrequency: a 16-week prospective, randomized split-face study. Acta Derm Venereol 2017; 97: 947\u2013951.","DOI":"10.2340\/00015555-2701"},{"key":"116550","doi-asserted-by":"crossref","unstructured":"Kwon HH, Yang SH, Lee J, Park BC, Park KY, Jung JY, et al. Combination treatment with human adipose tissue stem cell-derived exosomes and fractional CO2 laser for acne scars: a 12-week prospective, double-blind, randomized, split-face study. Acta Derm Venereol 2020; 100: adv00310.","DOI":"10.2340\/00015555-3666"},{"key":"116551","doi-asserted-by":"crossref","unstructured":"Gallo ES, Katz U, Artzi O. Fractional radiofrequency and oral isotretinoin: a prospective randomized controlled split-face trial comparing concurrent versus delayed fractional radiofrequency treatment for acne scars. Lasers Surg Med 2024; 56: 574\u2013580.","DOI":"10.1002\/lsm.23811"},{"key":"116552","doi-asserted-by":"crossref","unstructured":"Kim J, Lee SG, Choi S, Lee J, Lee YI, Kim J, et al. Combination of fractional microneedling radiofrequency and ablative fractional laser versus ablative fractional laser alone for acne and acne scars. Yonsei Med J 2023; 64: 721\u2013729.","DOI":"10.3349\/ymj.2023.0234"},{"key":"116553","doi-asserted-by":"crossref","unstructured":"Niaz G, Ajeebi Y, Alshamrani HM, Khalmurad M, Lee K. Fractional radiofrequency microneedling as a monotherapy in acne scar management: a systematic review of current evidence. Clin Cosmet Investig Dermatol 2025; 18: 19\u201329.","DOI":"10.2147\/CCID.S502295"},{"key":"116554","doi-asserted-by":"crossref","unstructured":"Mirza HN, Mirza FN, Khatri KA. Outcomes and adverse effects of ablative vs nonablative lasers for skin resurfacing: a systematic review of 1093 patients. Dermatol Ther 2021; 34: e14432.","DOI":"10.1111\/dth.14432"},{"key":"116555","doi-asserted-by":"crossref","unstructured":"Walgrave SE, Ortiz AE, MacFalls HT, Elkeeb L, Truitt AK, Tournas JA, et al. Evaluation of a novel fractional resurfacing device for treatment of acne scarring. Lasers Surg Med 2009; 41: 122\u2013127.","DOI":"10.1002\/lsm.20725"},{"key":"116556","doi-asserted-by":"crossref","unstructured":"Manuskiatti W, Triwongwaranat D, Varothai S, Eimpunth S, Wanitphakdeedecha R. Efficacy and safety of a carbon-dioxide ablative fractional resurfacing device for treatment of atrophic acne scars in Asians. 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Safety and efficacy of fractional radiofrequency for the treatment and reduction of acne scarring: a prospective study. Lasers Surg Med 2022; 54: 74\u201381.","DOI":"10.1002\/lsm.23453"},{"key":"116561","doi-asserted-by":"crossref","unstructured":"Al-Muriesh M, Huang CZ, Ye Z, Yang J. Dermoscopy and VISIA imager evaluations of non-insulated microneedle radiofrequency versus fractional CO(2) laser treatments of striae distensae. J Eur Acad Dermatol Venereol 2020; 34: 1859\u20131866.","DOI":"10.1111\/jdv.16266"},{"key":"116562","doi-asserted-by":"crossref","unstructured":"Lan T, Tang L, Xia A, Hamblin MR, Jian D, Yin R. Comparison of fractional micro-plasma radiofrequency and fractional microneedle radiofrequency for the treatment of atrophic acne scars: a pilot randomized split-face clinical study in China. 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J Clin Aesthet Dermatol 2018; 11: 41\u201344."},{"key":"116566","doi-asserted-by":"crossref","unstructured":"Xiao B, Jiang Y, Wang B, Hu Y, Sun Y, Wu Y, et al. A retrospective study of neck rejuvenation using a noninsulated microneedle radiofrequency in Chinese subjects. Lasers Med Sci 2021; 36: 1261\u20131266.","DOI":"10.1007\/s10103-020-03175-z"},{"key":"116567","doi-asserted-by":"crossref","unstructured":"Ong MW, Bashir SJ. Fractional laser resurfacing for acne scars: a review. Br J Dermatol 2012; 166: 1160\u20131169.","DOI":"10.1111\/j.1365-2133.2012.10870.x"},{"key":"116568","doi-asserted-by":"crossref","unstructured":"Naouri M, Mazer JM. Non-insulated microneedle fractional radiofrequency for the treatment of scars and photoaging. J Eur Acad Dermatol Venereol 2016; 30: 499\u2013502.","DOI":"10.1111\/jdv.12890"},{"key":"116569","doi-asserted-by":"crossref","unstructured":"Gold M, Taylor M, Rothaus K, Tanaka Y. 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The 1,450-nm diode laser reduces sebum production in facial skin: a possible mode of action of its effectiveness for the treatment of acne vulgaris. Lasers Surg Med 2007; 39: 189\u2013192.","DOI":"10.1002\/lsm.20465"},{"key":"116579","doi-asserted-by":"crossref","unstructured":"Rajput CD, Gore SB, Ansari MK, Shah SM. A prospective, nonrandomized, open-label study, comparing the efficacy, safety, and tolerability of fractional CO(2) laser versus fractional microneedling radio frequency in acne scars. J Cutan Aesthet Surg 2021; 14: 177\u2013183.","DOI":"10.4103\/JCAS.JCAS_65_19"},{"key":"116580","doi-asserted-by":"crossref","unstructured":"Sriram R, Chandrashekar BS, C M, Gowda HH. Comparative study in treatment of acne scars fractional carbon dioxide laser versus micro needling fractional radio frequency: a retrospective study. 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