{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:54:30Z","timestamp":1779108870235,"version":"3.51.4"},"reference-count":23,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Derm Venereol"],"abstract":"<jats:p>Prurigo nodularis (PN) is a chronic, itchy, inflammatory skin condition that negatively affects quality of life. A study was undertaken to investigate the healthcare utilization, including treatment patterns and direct costs for specialist care, for PN in Sweden. Linkage cohorts were created from national Swedish patient and prescription registers, and the cost-per-patient database of PN adults in specialist care in Sweden from 2015 to 2020. Around 875 patients were registered annually with a specialist diagnosis of PN in Sweden, with 3,548 specialist visits per year on average. In patients with severe PN with AD, the most common treatment sequence was topical treatment with corticosteroids followed by systemic prednisolone and methotrexate (32.6%). More than one-fifth of individuals with PN, and most with severe PN, had treatment for more than 1 year. For in- and outpatient care, the mean cost per visit was \u20ac458.6 and per patient per year around \u20ac1,862. The total annual cost of PN patients is estimated to be \u20ac1.6 million in Sweden. A high proportion of patients are treated for years with several, often systemic, treatment sequels. Targeted treatments for PN might improve patients\u2019 quality of life and reduce the high related costs for the healthcare system.<\/jats:p>","DOI":"10.2340\/actadv.v105.43730","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T12:04:22Z","timestamp":1755518662000},"page":"adv43730","source":"Crossref","is-referenced-by-count":1,"title":["Treatment Patterns, Healthcare Utilization, and Related Costs for Prurigo Nodularis in Sweden"],"prefix":"10.2340","volume":"105","author":[{"given":"Laura","family":"Von Kobyletzki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Metsini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon E.","family":"Regnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Carlberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c5ke","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annarita","family":"Antelmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1183","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"key":"121488","doi-asserted-by":"crossref","unstructured":"Huang AH, Williams KA, Kwatra SG. Prurigo nodularis: epidemiology and clinical features. J Am Acad Dermatol 2020; 83: 1559\u20131565.","DOI":"10.1016\/j.jaad.2020.04.183"},{"key":"121489","doi-asserted-by":"crossref","unstructured":"Kwatra SG. Breaking the itch\u2013scratch cycle in prurigo nodularis. N Engl J Med 2020; 382: 757\u2013758.","DOI":"10.1056\/NEJMe1916733"},{"key":"121490","unstructured":"Leis M, Fleming P, Lynde CW. Prurigo nodularis: review and emerging treatments. Skin Therapy Lett 2021; 26: 5\u20138. PMID: 34077168."},{"key":"121491","doi-asserted-by":"crossref","unstructured":"Mollanazar NK, Sethi M, Rodriguez RV, Nattkemper LA, Ramsey FV, Zhao H, et al. Retrospective analysis of data from an itch center: integrating validated tools in the electronic health record. J Am Acad Dermatol 2016; 75: 842\u2013844.","DOI":"10.1016\/j.jaad.2016.05.035"},{"key":"121492","doi-asserted-by":"crossref","unstructured":"Huang AH, Canner JK, Khanna R, Kang S, Kwatra SG. Real-world prevalence of prurigo nodularis and burden of associated diseases. J Invest Dermatol 2020; 140: 480\u2013483.","DOI":"10.1016\/j.jid.2019.07.697"},{"key":"121493","doi-asserted-by":"crossref","unstructured":"Larson VA, Tang O, St\u00e4nder S, Miller LS, Kang S, Kwatra SG. Association between prurigo nodularis and malignancy in middle-aged adults. J Am Acad Dermatol 2019; 81: 1198\u20131201.","DOI":"10.1016\/j.jaad.2019.03.083"},{"key":"121494","doi-asserted-by":"crossref","unstructured":"Whang KA, Le TK, Khanna R, Williams KA, Roh YS, Sutaria N, et al. Health-related quality of life and economic burden of prurigo nodularis. J Am Acad Dermatol 2022; 86: 537\u2013580.","DOI":"10.1016\/j.jaad.2021.05.036"},{"key":"121495","doi-asserted-by":"crossref","unstructured":"Antelmi A, Metsini A, Regnell SE, Carlberg M, Svensson \u00c5, von Kobyletzki L. Prevalence of prurigo nodularis in Sweden. 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