{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:24:20Z","timestamp":1784291060189,"version":"3.55.0"},"reference-count":41,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Derm Venereol"],"abstract":"<jats:p>Lichen simplex chronicus is a chronic pruritic skin condition that significantly impacts quality of life. This retrospective study analysed 125 patients with clinically confirmed lichen simplex chronicus seen at a tertiary academic centre to characterize itch severity, anatomical distribution, and associated comorbidities. Itch intensity was assessed using the Numerical Rating Scale (NRS), and clinical data were stratified by demographics and disease extent. Most patients (75%) reported moderate-to-severe itch (NRS 4\u201310), with nearly 90% experiencing daily pruritus and half reporting both daytime and nocturnal symptoms. The limbs were the most commonly affected sites. Comorbid conditions were frequent, including generalized anxiety disorder (50% vs ~3% in the US adult population), major depressive disorder (44% vs ~8%), hypertension (61% vs ~45%), and type 2 diabetes (30% vs ~11%). Patients with multiple-lesion lichen simplex chronicus had significantly higher itch severity (mean NRS 7.81 vs 7.08, p\u2009=\u20090.001) and were more likely to be female (81% vs 46%, p\u2009=\u20090.002) compared with those with localized disease. These findings highlight the high symptom burden and frequent co-occurrence of psychiatric and metabolic comorbidities in lichen simplex chronicus. Thus, early identification and management of psychiatric, neurological, and metabolic conditions may improve outcomes for patients with lichen simplex chronicus.<\/jats:p>","DOI":"10.2340\/actadv.v105.43776","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T06:23:36Z","timestamp":1757053416000},"page":"adv43776","source":"Crossref","is-referenced-by-count":2,"title":["A Retrospective Analysis of Itch Intensity and Comorbidities in Lichen Simplex Chronicus"],"prefix":"10.2340","volume":"105","author":[{"given":"Kayla D.","family":"Mashoudy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joselyn","family":"Ye-Tay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Yosipovitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"125856","doi-asserted-by":"crossref","unstructured":"Farage MA, Miller KW, Berardesca E, Maibach HI. Clinical implications of aging skin: cutaneous disorders in the elderly. Am J Clin Dermatol 2009; 10: 73\u201386.","DOI":"10.2165\/00128071-200910020-00001"},{"key":"125857","doi-asserted-by":"crossref","unstructured":"Tianco EA, Buendia-Teodosio G, Alberto NL. Survey of skin lesions in the Filipino elderly. Int J Dermatol 1992; 31: 196\u2013198.","DOI":"10.1111\/j.1365-4362.1992.tb03935.x"},{"key":"125858","doi-asserted-by":"crossref","unstructured":"Valdes-Rodriguez R, Stull C, Yosipovitch G. Chronic pruritus in the elderly: pathophysiology, diagnosis and management. Drugs Aging 2015; 32: 201\u2013215.","DOI":"10.1007\/s40266-015-0246-0"},{"key":"125859","doi-asserted-by":"crossref","unstructured":"Konuk N, Koca R, Atik L, Muhtar S, Atasoy N, Bostanci B. Psychopathology, depression and dissociative experiences in patients with lichen simplex chronicus. 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The effect of transcutaneous electrical nerve stimulation in the treatment of lichen simplex: a prospective study. Clin Exp Dermatol 2009; 34: 324\u2013328.","DOI":"10.1111\/j.1365-2230.2008.03086.x"},{"key":"125868","doi-asserted-by":"crossref","unstructured":"Visconti MJ, Haidari W, Feldman SR. Transcutaneous electrical nerve stimulation (TENS): a review of applications in dermatology. J Dermatolog Treat 2020; 31: 846\u2013849.","DOI":"10.1080\/09546634.2019.1657227"},{"key":"125869","doi-asserted-by":"crossref","unstructured":"Goldstein AT, Parneix-Spake A, McCormick CL, Burrows LJ. Pimecrolimus cream 1% for treatment of vulvar lichen simplex chronicus: an open-label, preliminary trial. Gynecol Obstet Invest 2007; 64: 180\u2013186.","DOI":"10.1159\/000106487"},{"key":"125870","doi-asserted-by":"crossref","unstructured":"Yosipovitch G, Sugeng MW, Chan YH, Goon A, Ngim S, Goh CL. The effect of topically applied aspirin on localized circumscribed neurodermatitis. 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