{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T12:24:01Z","timestamp":1773404641427,"version":"3.50.1"},"reference-count":25,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Derm Venereol"],"abstract":"<jats:p>Contact urticaria syndrome, encompassing immunological contact urticaria and protein contact dermatitis, comprises immediate cutaneous reactions with potential systemic manifestations, including anaphylaxis. These conditions are frequently underdiagnosed despite their significant occupational impact. This study aimed to evaluate the clinical and laboratory features associated with distinct phenotypes of contact urticaria syndrome. A retrospective, observational analysis was performed at Hospital del Mar (Barcelona) from January 2010 to January 2024, including adult patients diagnosed with immunological contact urticaria and\/or protein contact dermatitis and a positive prick test. Demographic data, clinical data, and complementary test results, including culprit agents, were compared between patients with isolated contact urticaria and those with protein contact dermatitis. A total of 95 patients were included. Results indicated that isolated contact urticaria was more frequently associated with facial involvement (n\u2009=\u200919, 28.8%) and a higher rate of systemic reactions (n\u2009=\u200918, 27.3%), including anaphylaxis, whereas protein contact dermatitis was frequently occupational-related (n\u2009=\u200919, 65.5%), and with a trend toward higher atopic dermatitis comorbidity (n\u2009=\u200912, 41.4%). These findings emphasize the heterogeneity of contact urticaria syndrome and underscore the importance of comprehensive clinical evaluation for effective diagnosis and management.<\/jats:p>","DOI":"10.2340\/actadv.v105.43837","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T12:58:04Z","timestamp":1761137884000},"page":"adv43837","source":"Crossref","is-referenced-by-count":2,"title":["Characterization of Contact Urticaria Syndrome Phenotypes: A Retrospective Study of 95 Cases"],"prefix":"10.2340","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5821-9780","authenticated-orcid":false,"given":"David","family":"Pesqu\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paloma","family":"Torros-Bos\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2166-6760","authenticated-orcid":false,"given":"Evelyn","family":"Andrades","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5622-6055","authenticated-orcid":false,"given":"Ramon M.","family":"Pujol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8996-3828","authenticated-orcid":false,"given":"Fernando","family":"Gallardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5434-7753","authenticated-orcid":false,"given":"Ana M.","family":"Gimenez-Arnau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1183","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"130460","doi-asserted-by":"crossref","unstructured":"Gim\u00e9nez-Arnau AM, Pesqu\u00e9 D, Maibach HI. Contact urticaria syndrome: a comprehensive review. Curr Derm Rep 2022; 11: 194\u2013201.","DOI":"10.1007\/s13671-022-00379-0"},{"key":"130461","doi-asserted-by":"crossref","unstructured":"Grattan CE, Mahler V. Immediate contact reactions: pathomechanisms and clinical presentation. In: Johansen JD, Mahler V, Lepoittevin J-P, Frosch PJ, editors. Contact dermatitis. Cham: Springer International Publishing, 2020; p. 1\u201316.","DOI":"10.1007\/978-3-319-72451-5_60-1"},{"key":"130462","doi-asserted-by":"crossref","unstructured":"Bizjak M, Aerts O, Pesqu\u00e9 D, Mu\u00f1oz M, Asero R, Gon\u00e7alo M, et al. Contact urticaria and related conditions: clinical review. Contact Dermatitis 2025; 93: 87-107.","DOI":"10.1111\/cod.14794"},{"key":"130463","doi-asserted-by":"crossref","unstructured":"Gimenez-Arnau AM, Maibach H. Contact urticaria. Immunol Allergy Clin North Am 2021; 41: 467\u2013480.","DOI":"10.1016\/j.iac.2021.04.007"},{"key":"130464","doi-asserted-by":"crossref","unstructured":"Barbaud A, Poreaux C, Penven E, Waton J. Occupational protein contact dermatitis. Eur J Dermatol 2015; 25: 527\u2013534.","DOI":"10.1684\/ejd.2015.2593"},{"key":"130465","doi-asserted-by":"crossref","unstructured":"Pesonen M, Koskela K, Aalto-Korte K. Contact urticaria and protein contact dermatitis in the Finnish Register of Occupational Diseases in a period of 12 years. Contact Dermatitis 2020; 83: 1\u20137.","DOI":"10.1111\/cod.13547"},{"key":"130466","doi-asserted-by":"crossref","unstructured":"Pesqu\u00e9 D, Aerts O, Bizjak M, Gon\u00e7alo M, Dugonik A, Simon D, et al. Differential diagnosis of contact dermatitis: a practical-approach review by the EADV Task Force on contact dermatitis. J Eur Acad Dermatol Venereol 2024; 38: 1704\u20131722.","DOI":"10.1111\/jdv.20052"},{"key":"130467","doi-asserted-by":"crossref","unstructured":"Luk\u00e1cs J, Schliemann S, Elsner P. Occupational contact urticaria caused by food: a systematic clinical review. Contact Dermatitis 2016; 75: 195\u2013204.","DOI":"10.1111\/cod.12653"},{"key":"130468","unstructured":"Onesimo R, Giorgio V, Pill S, Monaco S, Sopo SM. Isolated contact urticaria caused by immunoglobulin E-mediated fish allergy. Isr Med Assoc J 2012; 14: 11\u201313."},{"key":"130469","doi-asserted-by":"crossref","unstructured":"Schweitzer JA, Maibach HI. Immediate-type testing: immunologic contact urticaria and immunologic contact urticaria dermatitis. In: Lachapelle J-M, Bruze M, Elsner PU, editors. Patch testing tips. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014; p. 161\u2013165.","DOI":"10.1007\/978-3-642-45395-3_15"},{"key":"130470","doi-asserted-by":"crossref","unstructured":"Johansen JD, Aalto-Korte K, Agner T, Andersen KE, Bircher A, Bruze M, et al. European Society of Contact Dermatitis guideline for diagnostic patch testing: recommendations on best practice. Contact Dermatitis 2015; 73: 195\u2013221.","DOI":"10.1111\/cod.12432"},{"key":"130471","doi-asserted-by":"crossref","unstructured":"Pesqu\u00e9 D, Ciudad A, Andrades E, Soto D, Gimeno R, Pujol RM, et al. Solar urticaria: an ambispective study in a long-term follow-up cohort with emphasis on therapeutic predictors and outcomes. Acta Derm Venereol 2024; 104: adv25576.","DOI":"10.2340\/actadv.v104.25576"},{"key":"130472","doi-asserted-by":"crossref","unstructured":"Kanerva L, Toikkanen J, Jolanki R, Estlander T. Statistical data on occupational contact urticaria. Contact Dermatitis 1996; 35: 229\u2013233.","DOI":"10.1111\/j.1600-0536.1996.tb02363.x"},{"key":"130473","doi-asserted-by":"crossref","unstructured":"Wakelin SH. Contact urticaria. Clin Exp Dermatol 2001; 26: 132\u2013136.","DOI":"10.1046\/j.1365-2230.2001.00780.x"},{"key":"130474","doi-asserted-by":"crossref","unstructured":"Chang YC, George SJ, Hsu S. Oral allergy syndrome and contact urticaria to apples. J Am Acad Dermatol 2005; 53: 736\u2013737.","DOI":"10.1016\/j.jaad.2004.09.041"},{"key":"130475","doi-asserted-by":"crossref","unstructured":"Konstantinou GN, Grattan CEH. Food contact hypersensitivity syndrome: the mucosal contact urticaria paradigm. Clin Exp Dermatol 2008; 33: 383\u2013389.","DOI":"10.1111\/j.1365-2230.2008.02893.x"},{"key":"130476","doi-asserted-by":"crossref","unstructured":"Pesqu\u00e9 D, Canal-Garcia E, Rozas-Mu\u00f1oz E, Pujol RM, Gim\u00e9nez-Arnau AM. Non-occupational protein contact dermatitis induced by mango fruit. 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SPDV 2018; 76: 143\u2013150.","DOI":"10.29021\/spdv.76.2.896"},{"key":"130484","doi-asserted-by":"crossref","unstructured":"Ansotegui IJ, Melioli G, Canonica GW, Caraballo L, Villa E, Ebisawa M, et al. IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper. World Allergy Organ J 2020; 13: 100080.","DOI":"10.1016\/j.waojou.2019.100080"}],"container-title":["Acta Dermato-Venereologica"],"original-title":[],"link":[{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/download\/43837\/51794","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/download\/43837\/51794","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T12:58:10Z","timestamp":1761137890000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/view\/43837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,22]]},"references-count":25,"URL":"https:\/\/doi.org\/10.2340\/actadv.v105.43837","relation":{},"ISSN":["1651-2057","0001-5555"],"issn-type":[{"value":"1651-2057","type":"electronic"},{"value":"0001-5555","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10,22]]}}}