{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:43:04Z","timestamp":1791999784333,"version":"4.4.0"},"reference-count":53,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Derm Venereol"],"abstract":"<jats:p>Chronic pruritus is a burdensome condition that frequently affects older adults, yet its epidemiology and impact on quality of life in the ageing population remain underexplored. This cross-sectional study examined the prevalence of chronic pruritus, its associated factors, and pruritus-specific quality of life in 4,474 participants (median age: 72 years; range: 48\u201399, 58.8% female) from the population-based Rotterdam Study. Questionnaires assessed current, 12-month, and lifetime chronic pruritus, along with the ItchyQoL. Multivariable logistic regression identified factors associated with chronic pruritus, and linear regression assessed factors linked to pruritus-specific quality of life. Principal component analysis explored the ItchyQoL\u2019s dimensional structure in this older population. Chronic pruritus prevalence was 8.6% (current), 10.5% (12-month), and 18.6% (lifetime). Female sex, older age, smoking, atopic dermatitis, psoriasis, self-reported dry skin, asthma, steatotic liver disease, polyneuropathy, depressive symptoms, anxiety, and poor sleep were associated with higher odds of chronic pruritus. Among those with current chronic pruritus, pruritus-specific quality of life was moderately impaired, with the greatest impairment associated with atopic dermatitis and psychological symptoms. Principal component analysis identified 4 ItchyQoL dimensions, extending beyond the original 3 domains. Given the cross-sectional design, directionality cannot be inferred. These findings highlight chronic pruritus as a prevalent, multifactorial condition in older adults, with significant psychological impact and implications for multidisciplinary management.<\/jats:p>","DOI":"10.2340\/actadv.v105.44313","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T13:30:39Z","timestamp":1762781439000},"page":"adv44313","source":"Crossref","is-referenced-by-count":6,"title":["Chronic Pruritus in Older Adults: Prevalence, Associations, and Pruritus-specific Quality of Life"],"prefix":"10.2340","volume":"105","author":[{"given":"Juliette F.","family":"Bollemeijer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathijs R.","family":"De Veer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Weisshaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem P.","family":"Brouwer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lies","family":"Lahousse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Gunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar E.C.","family":"Nijsten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luba M.","family":"Pardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"132181","doi-asserted-by":"crossref","unstructured":"Yosipovitch G, Rosen JD, Hashimoto T. 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