{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:11:03Z","timestamp":1777633863528,"version":"3.51.4"},"reference-count":22,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Derm Venereol"],"abstract":"<jats:p>Secondary intent healing is a viable option for wound closure after facial tumour removal by Mohs micrographic surgery. Secondary intent healing involves prolonged healing time and carries risk of infection and complications related to scarring. Healing with an autologous patch made from the patient\u2019s own blood may be beneficial. This study on 22 patients evaluates the effect of applying an autologous patch to the wound after Mohs micrographic surgery. A randomized controlled assessor-blinded trial was carried out. Patients had Mohs micrographic surgery on day 0 and clinical evaluation on day 12, day 19, and after 6 months. Transepidermal water loss was measured on day 12 and day 19. Reflectance confocal microscopy was applied exploratively. At 6 months\u2019 follow-up the Patient and Observer Scar Assessment Scale was evaluated. Primary outcome was fully epithelialized wounds on day 19 and secondary outcome was 50% epithelialized wounds on day 12. One wound from each group was fully epithelialized and wound area reduction was higher in the patch group although not significant. Transepidermal water loss decreased to a larger extent, indicating that the patch creates a moist environment. Wound healing with an autologous patch is equivalent to secondary intent healing but may prompt benefits in certain wound healing factors. Patch healing appears safe with high patient satisfaction.<\/jats:p>","DOI":"10.2340\/actadv.v106.43586","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:57:02Z","timestamp":1777438622000},"page":"adv43586","source":"Crossref","is-referenced-by-count":0,"title":["Autologous Patch Healing vs Secondary Intent Healing after Mohs Micrographic Surgery: A Randomized Controlled Trial"],"prefix":"10.2340","volume":"106","author":[{"given":"Marie K.","family":"Hjorth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa A.","family":"Burian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonny","family":"Karlsmark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette","family":"Mogensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Glud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Ahm","family":"Harager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrine E.","family":"Karmisholt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1183","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"153361","unstructured":"Enache AO, P\u0103tra\u0219cu V, Simionescu CE, Ciurea RN, V\u0103duva A, Stoica LE. 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Psychosocial and quality of life impact of scars in the surgical, traumatic and burn populations: a scoping review protocol. BMJ Open 2019; 9: e021289.","DOI":"10.1136\/bmjopen-2017-021289"},{"key":"153365","doi-asserted-by":"crossref","unstructured":"Zitelli JA. Secondary intention healing: an alternative to surgical repair. Clin Dermatol 1984; 2: 92\u2013106.","DOI":"10.1016\/0738-081X(84)90031-2"},{"key":"153366","doi-asserted-by":"crossref","unstructured":"Ranjbar_moghaddam M, Merajikhah A, Mahdood B, Mousavi E, Bastami M. Analyzing outcomes of platelet-rich plasma usage on surgical wounds: a systematic review. Curr Probl Surg 2025; 64: 101704.","DOI":"10.1016\/j.cpsurg.2024.101704"},{"key":"153367","doi-asserted-by":"crossref","unstructured":"Chicharro-Alc\u00e1ntara D, Rubio-Zaragoza M, Dami\u00e1-Gim\u00e9nez E, Carrillo-Poveda JM, Cuervo-Serrato B, Pel\u00e1ez-Gorrea P, et al. Platelet rich plasma: new insights for cutaneous wound healing management. 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Int J Low Extrem Wounds 2011; 10: 218\u2013223.","DOI":"10.1177\/1534734611426755"},{"key":"153371","doi-asserted-by":"crossref","unstructured":"Chavez-Bourgeois M, Ribero S, Barreiro A, Espinosa N, Carrera C, Garcia A, et al. Reflectance confocal microscopy and electrical impedance spectroscopy in the early detection of melanoma in changing lesions during long-term follow-up of very high-risk patients. Acta Derm Venereol 2022; 102: adv00751.","DOI":"10.2340\/actadv.v102.1105"},{"key":"153372","doi-asserted-by":"crossref","unstructured":"von Knorring T, M\u00f8ller Israelsen N, Ung V, Formann JL, Jensen M, Haedersdal M, et al. Differentiation between benign and malignant pigmented skin tumours using bedside diagnostic imaging technologies: a pilot study. Acta Derm Venereol 2022; 102: adv00634.","DOI":"10.2340\/actadv.v101.571"},{"key":"153373","doi-asserted-by":"crossref","unstructured":"del R\u00edo-Sancho S, Christen-Zaech S, Alvarez Martinez D, P\u00fcnchera J, Merat R, Laubach HJ. Comparing line-field confocal optical coherence tomography and reflectance confocal microscopy on the in vivo healing process of lesions induced by fractional photothermolysis. Lasers Surg Med 2025; 57: 121\u2013129.","DOI":"10.1002\/lsm.23841"},{"key":"153374","doi-asserted-by":"crossref","unstructured":"Guida S, Longo C, Amato S, Rossi AM, Manfredini M, Ciardo S, et al. Laser treatment monitoring with reflectance confocal microscopy. Medicina (Kaunas) 2023; 59: 1039.","DOI":"10.3390\/medicina59061039"},{"key":"153375","doi-asserted-by":"crossref","unstructured":"Game F, Jeffcoate W, Tarnow L, Jacobsen JL, Whitham DJ, Harrison EF, et al. LeucoPatch system for the management of hard-to-heal diabetic foot ulcers in the UK, Denmark, and Sweden: an observer-masked, randomised controlled trial. 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