{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:52:04Z","timestamp":1783021924751,"version":"3.54.6"},"reference-count":38,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Derm Venereol"],"abstract":"<jats:p>Emerging evidence has suggested a link between new-onset psoriasis and both COVID-19 infection and vaccination, though findings have been limited by small case numbers and lack of adequate control groups. This retrospective cohort study used electronic health records from the US Collaborative Network of TriNetX from January 2020 to January 2025 to compare the risk of developing new-onset psoriasis in individuals with confirmed COVID-19 infection and no vaccination history vs those vaccinated without prior infection. Propensity score matching was applied to balance demographics, comorbidities, and psoriasis risk factors. The primary outcome was a new diagnosis of psoriasis (ICD10-CM: L40.0\u20135) within 3 months following infection or vaccination. Subgroup analyses assessed the specific codes L40.0-5 separately. Kaplan\u2013Meier survival analysis and Cox proportional hazards models were used to compare outcomes. Patients with COVID-19 infection had a significantly higher risk of developing psoriasis compared with vaccinated individuals (HR 1.30; 95% CI, 1.14\u20131.49; p\u2009&lt;\u20090.001). Increased risks were also observed for psoriatic arthritis and pustulosis palmaris et plantaris. These findings suggest a potential triggering role of infection in psoriasis pathogenesis and support the safety profile of vaccination. Further studies are needed to confirm causality and guide clinical decision-making.<\/jats:p>","DOI":"10.2340\/actadv.v106.44217","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T06:54:56Z","timestamp":1767941696000},"page":"adv44217","source":"Crossref","is-referenced-by-count":2,"title":["COVID-19 Infection vs Vaccination and the Risk of New-onset Psoriasis"],"prefix":"10.2340","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0661-7573","authenticated-orcid":false,"given":"Sophie L.","family":"Preu\u00df","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0863-7148","authenticated-orcid":false,"given":"Henning","family":"Olbrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-6683","authenticated-orcid":false,"given":"Katja","family":"Bieber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1542-0732","authenticated-orcid":false,"given":"Artem","family":"Vorobyev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7124-0146","authenticated-orcid":false,"given":"Eva Lotta","family":"Moderegger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9971-9151","authenticated-orcid":false,"given":"Khalaf","family":"Kridin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0053-4312","authenticated-orcid":false,"given":"Henner","family":"Zirpel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8513-550X","authenticated-orcid":false,"given":"Diamant","family":"Tha\u00e7i","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4639-9841","authenticated-orcid":false,"given":"Evelyn","family":"Gaffal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1394-1737","authenticated-orcid":false,"given":"Ralf J.","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2051-8491","authenticated-orcid":false,"given":"Philip","family":"Curman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"138116","unstructured":"Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950\u20132021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021. Lancet 2024; 403: 1989\u20132056."},{"key":"138117","doi-asserted-by":"crossref","unstructured":"Telfer NR, Chalmers RJ, Whale K, Colman G. The role of streptococcal infection in the initiation of guttate psoriasis. Arch Dermatol 1992; 128: 39\u201342.","DOI":"10.1001\/archderm.1992.01680110049004"},{"key":"138118","unstructured":"Lee EB, Wu KK, Lee MP, Bhutani T, Wu JJ. Psoriasis risk factors and triggers. Cutis 2018; 102: 18\u201320."},{"key":"138119","doi-asserted-by":"crossref","unstructured":"Gunes AT, Fetil E, Akarsu S, Ozbagcivan O, Babayeva L. Possible triggering effect of influenza vaccination on psoriasis. J Immunol Res 2015; 2015: 258430.","DOI":"10.1155\/2015\/258430"},{"key":"138120","doi-asserted-by":"crossref","unstructured":"Takayama K, Satoh T, Hayashi M, Yokozeki H. Psoriatic skin lesions induced by BCG vaccination. Acta Derm Venereol 2008; 88: 621\u2013622.","DOI":"10.2340\/00015555-0496"},{"key":"138121","doi-asserted-by":"crossref","unstructured":"Shin MS, Kim SJ, Kim SH, Kwak YG, Park HJ. New onset guttate psoriasis following pandemic H1N1 influenza vaccination. Ann Dermatol 2013; 25: 489\u2013492.","DOI":"10.5021\/ad.2013.25.4.489"},{"key":"138122","doi-asserted-by":"crossref","unstructured":"Macias VC, Cunha D. Psoriasis triggered by tetanus-diphtheria vaccination. Cutan Ocul Toxicol 2013; 32: 164\u2013165.","DOI":"10.3109\/15569527.2012.727936"},{"key":"138123","doi-asserted-by":"crossref","unstructured":"Rahman MM, Masum MHU, Wajed S, Talukder A. A comprehensive review on COVID-19 vaccines: development, effectiveness, adverse effects, distribution and challenges. Virusdisease 2022; 33: 1\u201322.","DOI":"10.1007\/s13337-022-00755-1"},{"key":"138124","doi-asserted-by":"crossref","unstructured":"Wu PC, Huang IH, Wang CW, Tsai CC, Chung WH, Chen CB. New onset and exacerbations of psoriasis following COVID-19 vaccines: a systematic review. Am J Clin Dermatol 2022; 23: 775\u2013799.","DOI":"10.1007\/s40257-022-00721-z"},{"key":"138125","doi-asserted-by":"crossref","unstructured":"Potestio L, Battista T, Cacciapuoti S, Ruggiero A, Martora F, Fornaro L, et al. New onset and exacerbation of psoriasis following COVID-19 vaccination: a review of the current knowledge. Biomedicines 2023; 11: 2191.","DOI":"10.3390\/biomedicines11082191"},{"key":"138126","doi-asserted-by":"crossref","unstructured":"Karampinis E, Papadopoulou MM, Chaidaki K, Georgopoulou KE, Magaliou S, Roussaki Schulze AV, et al. Plaque psoriasis exacerbation and COVID-19 vaccination: assessing the characteristics of the flare and the exposome parameters. Vaccines (Basel) 2024; 12: 178.","DOI":"10.3390\/vaccines12020178"},{"key":"138127","doi-asserted-by":"crossref","unstructured":"Wollina U, Karada\u011f AS, Rowland-Payne C, Chiriac A, Lotti T. Cutaneous signs in COVID-19 patients: a review. Dermatol Ther 2020; 33: e13549.","DOI":"10.1111\/dth.13549"},{"key":"138128","doi-asserted-by":"crossref","unstructured":"Hileman CO, Malakooti SK, Patil N, Singer NG, McComsey GA. New-onset autoimmune disease after COVID-19. Front Immunol 2024; 15: 1337406.","DOI":"10.3389\/fimmu.2024.1337406"},{"key":"138129","doi-asserted-by":"crossref","unstructured":"Goyal PK, Mohammed TO, Mahmoud A, Zaidi AJ, Nguyen CV. COVID-19 infection leading to acute pustular dermatoses. Arch Dermatol Res 2023; 315: 685\u2013697.","DOI":"10.1007\/s00403-022-02450-z"},{"key":"138130","doi-asserted-by":"crossref","unstructured":"Curman P, Kridin K, Zirpel H, Hernandez G, Akyuz M, Thaci D, et al. COVID-19 infection is associated with an elevated risk for autoimmune blistering diseases while COVID-19 vaccination decreases the risk: a large-scale population-based cohort study of 112 million individuals. J Am Acad Dermatol 2025; 92: 452\u2013463.","DOI":"10.1016\/j.jaad.2024.10.063"},{"key":"138131","doi-asserted-by":"crossref","unstructured":"Palchuk MB, London JW, Perez-Rey D, Drebert ZJ, Winer-Jones JP, Thompson CN, et al. A global federated real-world data and analytics platform for research. JAMIA Open 2023; 6: ooad035.","DOI":"10.1093\/jamiaopen\/ooad035"},{"key":"138132","doi-asserted-by":"crossref","unstructured":"Ludwig RJ, Anson M, Zirpel H, Thaci D, Olbrich H, Bieber K, et al. A comprehensive review of methodologies and application to use the real-world data and analytics platform TriNetX. Front Pharmacol 2025; 16: 1516126.","DOI":"10.3389\/fphar.2025.1516126"},{"key":"138133","doi-asserted-by":"crossref","unstructured":"Murakami M, Terui T. Palmoplantar pustulosis: current understanding of disease definition and pathomechanism. J Dermatol Sci 2020; 98: 13\u201319.","DOI":"10.1016\/j.jdermsci.2020.03.003"},{"key":"138134","doi-asserted-by":"crossref","unstructured":"Navarini AA, Burden AD, Capon F, Mrowietz U, Puig L, K\u00f6ks S, et al. European consensus statement on phenotypes of pustular psoriasis. J Eur Acad Dermatol Venereol 2017; 31: 1792\u20131799.","DOI":"10.1111\/jdv.14386"},{"key":"138135","doi-asserted-by":"crossref","unstructured":"Yamamoto T. Similarity and difference between palmoplantar pustulosis and pustular psoriasis. J Dermatol 2021; 48: 750\u2013760.","DOI":"10.1111\/1346-8138.15826"},{"key":"138136","doi-asserted-by":"crossref","unstructured":"Misiak-Galazka M, Zozula J, Rudnicka L. Palmoplantar pustulosis: recent advances in etiopathogenesis and emerging treatments. Am J Clin Dermatol 2020; 21: 355\u2013370.","DOI":"10.1007\/s40257-020-00503-5"},{"key":"138137","doi-asserted-by":"crossref","unstructured":"Twelves S, Mostafa A, Dand N, Burri E, Farkas K, Wilson R, et al. Clinical and genetic differences between pustular psoriasis subtypes. J Allergy Clin Immunol 2019; 143: 1021\u20131026.","DOI":"10.1016\/j.jaci.2018.06.038"},{"key":"138138","doi-asserted-by":"crossref","unstructured":"Passeron T, Perrot JL, Jullien D, Goujon C, Ruer M, Boy\u00e9 T, et al. Treatment of severe palmoplantar pustular psoriasis with bimekizumab. JAMA Dermatol 2024; 160: 199\u2013203.","DOI":"10.1001\/jamadermatol.2023.5051"},{"key":"138139","doi-asserted-by":"crossref","unstructured":"Bissonnette R, Su\u00e1rez-Fari\u00f1as M, Li X, Bonifacio KM, Brodmerkel C, Fuentes-Duculan J, et al. Based on molecular profiling of gene expression, palmoplantar pustulosis and palmoplantar pustular psoriasis are highly related diseases that appear to be distinct from psoriasis vulgaris. PLoS One 2016; 11: e0155215.","DOI":"10.1371\/journal.pone.0155215"},{"key":"138140","doi-asserted-by":"crossref","unstructured":"St\u00e4nder S, Zirpel H, Bujoreanu F, Tatu AL, Ludwig RJ, Tha\u00e7i D. Case report: Clinical features of COVID-19 vaccine-induced exacerbation of psoriasis \u2013 a case series and mini review. Front Med (Lausanne) 2022; 9: 995150.","DOI":"10.3389\/fmed.2022.995150"},{"key":"138141","doi-asserted-by":"crossref","unstructured":"Burshtein J, Strunk A, Garg A. Incidence of psoriasis among adults in the United States: a sex- and age-adjusted population analysis. J Am Acad Dermatol 2021; 84: 1023\u20131029.","DOI":"10.1016\/j.jaad.2020.11.039"},{"key":"138142","doi-asserted-by":"crossref","unstructured":"de Carvalho Braga G, Francisco GR, Bagatini MD. Current treatment of Psoriasis triggered by Cytokine Storm and future immunomodulation strategies. J Mol Med (Berl) 2024; 102: 1187\u20131198.","DOI":"10.1007\/s00109-024-02481-1"},{"key":"138143","doi-asserted-by":"crossref","unstructured":"Dorgham K, Quentric P, G\u00f6kkaya M, Marot S, Parizot C, Sauce D, et al. Distinct cytokine profiles associated with COVID-19 severity and mortality. J Allergy Clin Immunol 2021; 147: 2098\u20132107.","DOI":"10.1016\/j.jaci.2021.03.047"},{"key":"138144","doi-asserted-by":"crossref","unstructured":"Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395: 497\u2013506.","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"138145","doi-asserted-by":"crossref","unstructured":"Tan M, Liu Y, Zhou R, Deng X, Li F, Liang K, et al. Immunopathological characteristics of coronavirus disease 2019 cases in Guangzhou, China. Immunology 2020; 160: 261\u2013268.","DOI":"10.1111\/imm.13223"},{"key":"138146","doi-asserted-by":"crossref","unstructured":"Zhou X, Chen Y, Cui L, Shi Y, Guo C. Advances in the pathogenesis of psoriasis: from keratinocyte perspective. Cell Death Dis 2022; 13: 81.","DOI":"10.1038\/s41419-022-04523-3"},{"key":"138147","doi-asserted-by":"crossref","unstructured":"Arunachalam PS, Scott MKD, Hagan T, Li C, Feng Y, Wimmers F, et al. Systems vaccinology of the BNT162b2 mRNA vaccine in humans. Nature 2021; 596: 410\u2013416.","DOI":"10.1038\/s41586-021-03791-x"},{"key":"138148","doi-asserted-by":"crossref","unstructured":"Wang Y, Wang X, Luu LDW, Li J, Cui X, Yao H, et al. Single-cell transcriptomic atlas reveals distinct immunological responses between COVID-19 vaccine and natural SARS-CoV-2 infection. J Med Virol 2022; 94: 5304\u20135324.","DOI":"10.1002\/jmv.28012"},{"key":"138149","doi-asserted-by":"crossref","unstructured":"Rubin SC, Zacks N, Wand O, Freund O, Gershman E, Breslavsky A, et al. Cytokine fingerprint differences following infection and vaccination: what can we learn from COVID-19? Eur Cytokine Netw 2024; 35: 13\u201319.","DOI":"10.1684\/ecn.2024.0494"},{"key":"138150","doi-asserted-by":"crossref","unstructured":"Sugiura K, Fujita H, Komine M, Yamanaka K, Akiyama M. The role of interleukin-36 in health and disease states. J Eur Acad Dermatol Venereol 2024; 38: 1910\u20131925.","DOI":"10.1111\/jdv.19935"},{"key":"138151","doi-asserted-by":"crossref","unstructured":"Zhou Q, Vadakekolathu J, Watad A, Sharif K, Russell T, Rowe H, et al. SARS-CoV-2 infection induces psoriatic arthritis flares and enthesis resident plasmacytoid dendritic cell type-1 interferon inhibition by JAK antagonism offer novel spondyloarthritis pathogenesis insights. Front Immunol 2021; 12: 635018.","DOI":"10.3389\/fimmu.2021.635018"},{"key":"138152","doi-asserted-by":"crossref","unstructured":"Chaudhry ZS, Nellessen N, Reis C, Sharip A. The development of inflammatory arthritis following SARS-CoV-2 infection: a systematic review of the literature. Fam Pract 2022; 39: 1116\u20131134.","DOI":"10.1093\/fampra\/cmac029"},{"key":"138153","doi-asserted-by":"crossref","unstructured":"Hoxha A, Striani G, Lovisotto M, Simioni P, Doria A, Ramonda R. COVID-19 vaccine and the risk of flares in inflammatory arthritis: a systematic literature review and meta-analysis. Front Immunol 2024; 15: 1503895.","DOI":"10.3389\/fimmu.2024.1503895"}],"container-title":["Acta Dermato-Venereologica"],"original-title":[],"link":[{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/download\/44217\/52494","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/download\/44217\/52494","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T06:55:09Z","timestamp":1767941709000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicaljournalssweden.se\/actadv\/article\/view\/44217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,8]]},"references-count":38,"URL":"https:\/\/doi.org\/10.2340\/actadv.v106.44217","relation":{},"ISSN":["1651-2057","0001-5555"],"issn-type":[{"value":"1651-2057","type":"electronic"},{"value":"0001-5555","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,8]]}}}