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The OHRQoL was assessed using the Oral Health Impact Profile-14 at three intervals: prior to root canal treatment (T0), 7 (T7), and 30 (T30) days post-treatment. Genomic DNA was extracted from buccal cells for genotyping of polymorphisms in SOD2 (rs5746136, rs4880, and rs10370) and SOD3 (rs2855262 and rs13306703) using real-time PCR. Both Univariate and Multivariate Poisson Regression analyses were conducted, with p &lt; 0.05 indicating statistical significance.\u00a0\nResults: The rs2855262 polymorphism in the SOD3 gene showed a significant difference in the functional limitation domain in both codominant (p\u2009=\u20090.037) and recessive (p\u2009=\u20090.040) models. The rs13306703 polymorphism in SOD3 demonstrated a significant difference in physical pain [in codominant (p\u2009=\u20090.001) and recessive (p &lt; 0.001) models], psychological discomfort [in codominant (p\u2009=\u20090.002) and recessive (p\u2009=\u20090.002) models], handicap [in codominant (p\u2009=\u20090.011) and dominant (p\u2009=\u20090.015) models], and total score [in codominant (p\u2009=\u20090.011) and recessive (p\u2009=\u20090.007) models]. In the Multivariate Poisson Regression analysis, SOD2 (rs5746136) was associated with the psychological disability domain [in codominant (p\u2009=\u20090.049) and recessive (p\u2009=\u20090.040) models] and SOD3 (rs13306703), in the handicap domain [in codominant (p\u2009=\u20090.028) and dominant (p\u2009=\u20090.037) models].\u00a0\nConclusions: Genetic polymorphisms in SOD2 and SOD3 genes can influence the OHRQoL response in patients with asymptomatic periapical periodontitis.<\/jats:p>","DOI":"10.2340\/aos.v84.43426","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T13:29:13Z","timestamp":1745328553000},"page":"191-200","source":"Crossref","is-referenced-by-count":0,"title":["Is there an association between superoxide dismutase gene polymorphisms, antioxidants in oxidative stress pathway, and oral health-related quality of life after root canal treatment?"],"prefix":"10.2340","volume":"84","author":[{"given":"Ludmila","family":"Da Silva Guimar\u00e3es","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erlange Andrade","family":"Borges da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Miranda","family":"Bonelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heitor Ganier","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice Corr\u00eaa","family":"Silva-Sousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoel Dami\u00e3o","family":"Sousa-Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika Calvano","family":"K\u00fcchler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00edvia Azeredo Alves","family":"Antunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Signorelli","family":"Calazans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo Santos","family":"Antunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1183","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"108446","doi-asserted-by":"crossref","unstructured":"Glick M, Williams DM, Kleinman DV, Vujicic M, Watt RG, Weyant RJ. 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