{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T07:13:50Z","timestamp":1770448430736,"version":"3.49.0"},"reference-count":60,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AOS"],"abstract":"<jats:p>Objective ANRIL is a pleiotropic gene with a strong link to periodontitis. ANRIL gene variant rs1537373 is associated with altered CDKN2B gene expression, which is linked to obesity. In this explorative, cross-sectional population-based study, we aimed to investigate the hypothesis that ANRIL (rs1537373) T&gt;G may be associated with periodontitis through interactions, focusing on rs1537373\u00d7obesity interaction.\r\nMethods Genotyping for ANRIL (rs1537373), and clinical and periodontal examination were performed in 3554 participants (aged 40-93 years, 52% women) from the seventh survey of the Troms\u00f8 Study (2015\u20132016), Norway. We defined periodontitis stage based on radiographic bone loss (2018 AAP\/EFP classification).\r\nResults The individual association between rs1537373 and periodontitis, as well as multiplicative and additive interactions between rs1537373 and age, sex, smoking, and obesity on periodontitis under a recessive model were studied. We found multiplicative and additive interactions between rs1537373 and obesity. When compared with GT\/TT genotype and no obesity, GG genotype and obesity was associated with higher odds for periodontitis stage III-IV (OR=2.47, 95%CI=1.48-4.12, p=0.001; relative excess risk due to interaction=1.51, 95%CI=0.26-2.77, p=0.018; attributable proportion due to interaction=0.61; 95%CI=0.35-0.87, p&lt;0.001).\r\nConclusion Our findings suggest that rs1537373 GG genotype and obesity were jointly associated with periodontitis stage III-IV in this Norwegian population.<\/jats:p>","DOI":"10.2340\/aos.v84.44368","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T11:54:17Z","timestamp":1755172457000},"page":"426-438","source":"Crossref","is-referenced-by-count":0,"title":["An explorative study on the interaction of cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1\/ANRIL) gene polymorphism with obesity on periodontitis among Norwegian adults"],"prefix":"10.2340","volume":"84","author":[{"given":"Natalia","family":"Petrenya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila A.","family":"Hopstock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elin","family":"Hadler-Olsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farah","family":"Asa'ad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gro Eirin","family":"Holde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre R","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitta","family":"J\u00f6nsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1183","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"120776","unstructured":"Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, Fine DH, et al. 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