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Then the animals were randomly divided into two groups: placebo (n = 17) and resveratrol (n = 17). The placebo group received a placebo solution, while the resveratrol group received 10 mg\/kg resveratrol daily via oral gavage for 30 days. Alveolar bone loss was measured on microscopic photographs of stained tissue sections. Gingival enzyme activity levels were determined by enzyme-specific reactions and mRNA levels were assessed using semiquantitative real-time polymerase chain reaction (PCR).\r\nResults: Systemic resveratrol administration significantly reduced alveolar bone loss (440.87 \u00b1 142.24 \u03bcm) compared to the placebo group (897.06 \u00b1 383.59 \u03bcm) (p &lt; 0.001). Catalase and glutathione peroxidase activities were also significantly higher in the resveratrol group (p &lt; 0.001).\r\nConclusions: Resveratrol appears to be effective in reducing alveolar bone loss in experimental periodontitis, potentially through its antioxidant properties. These findings suggest that resveratrol may offer clinical benefit as an adjunct to periodontal therapy.<\/jats:p>","DOI":"10.2340\/aos.v84.44956","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:17:00Z","timestamp":1765808220000},"page":"607-615","source":"Crossref","is-referenced-by-count":2,"title":["Effect of resveratrol on the antioxidant enzyme pathway and alveolar bone loss in experimental periodontitis"],"prefix":"10.2340","volume":"84","author":[{"given":"Yasemin","family":"Sezgin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehtap","family":"Bilgin \u00c7etin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunus Kasim","family":"Terzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"Darcansoy \u0130\u015feri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilal","family":"Erinan\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feride \u0130ffet","family":"\u015eahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Batuhan","family":"Bak\u0131rarar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130dil","family":"\u00d6zerkli\u011f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eule","family":"Bulut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilg\u00fcn \u00d6zlem","family":"Alptekin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"135552","doi-asserted-by":"crossref","unstructured":"Gomes Muniz FWM, Nogueira SB, Vasconcelos Mendes FL, R\u00f6sing CK, Mendes Moreira MMS, De Andrade GM, et al. 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