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The aim was to assess the effects of alendronate and simvastatin, both alone and combined, on osteoblasts and gingival fibroblasts in vitro.\nStudy design: Primary human gingival fibroblasts and primary human osteoblasts were incubated with alendronate (5 \u00b5M) and simvastatin (1, 5 or 10 \u00b5M), alone or combined, for up to 14 days. Cells were assessed for viability by measuring lactate dehydrogenase activity and caspase-3 concentration in the cell culture media. Migration and proliferation potential was assessed by scratch-wound assay. Secreted levels of cytokines\/chemokines were measured using Luminex 200 multianalytic profiling. \nResults: High concentrations of simvastatin, both alone and combined with alendronate, affected the proliferation\/migration potential and reduced scratch closure. The same exposure induced near abolishment of secreted levels of cytokines affecting angiogenesis, such as VEGF, IL-6, IL-8, and MCP-1, however little effect was found on cell viability. \nConclusion: High concentrations of simvastatin, alone or combined with alendronate, may have a negative impact on angiogenetic markers and cell migration\/proliferation, affecting wound healing and growth.<\/jats:p>","DOI":"10.2340\/aos.v85.45585","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T15:11:23Z","timestamp":1773846683000},"page":"125-133","source":"Crossref","is-referenced-by-count":3,"title":["Bisphosphonate and statin: adverse effects of co-medication on wound healing in in vitro models of periodontal tissues"],"prefix":"10.2340","volume":"85","author":[{"given":"Agnes","family":"Sm\u00e5land-Reksten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E.","family":"Agger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aina M.","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne E.","family":"Reseland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tormod B.","family":"Kr\u00fcger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"145484","unstructured":"Dansie LS, Bakken GV, Berg CL, Blix HS, Ilic M, Litleskare I, et al. 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