{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:15:17Z","timestamp":1777864517459,"version":"3.51.4"},"reference-count":72,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AOS"],"abstract":"<jats:p>Background: Crohn\u2019s disease (CD) is a chronic inflammatory disorder with systemic manifestations, including potential effects on oral health. Evidence regarding its association with periodontal disease remains inconsistent.\nMethods: We systematically searched PubMed, Embase, Web of Science, Scopus, Cochrane Library, CNKI, and WanFang Data up to August 28, 2025, for observational studies comparing periodontal \u00adoutcomes in adults with CD and non-inflammatory bowel diseases controls. Random-effects meta-\u00adanalyses were \u00adperformed to estimate pooled odds ratios (ORs) for prevalence and standardized mean differences (SMDs) for clinical parameters. Subgroup and sensitivity analyses were conducted.\nResults: Thirty-four studies, including 6482 CD patients and 9137 controls, were analyzed. CD was \u00adassociated with a higher risk of periodontitis (OR = 2.14, 95% confidence interval [CI]: 1.65\u20132.77). Clinical periodontal parameters were also significantly worse in CD patients: probing depth (SMD = 0.42), clinical attachment loss (CAL) (SMD = 0.50), bleeding on probing (SMD = 0.47), plaque index (SMD = 0.39), and gingival index (SMD = 0.31). Associations were stronger in European populations and in studies using CAL criteria. Sensitivity analyses confirmed the robustness of results.\nConclusions: CD is associated with increased prevalence and severity of periodontal disease. These \u00adfindings support routine periodontal screening and integrated multidisciplinary management for CD patients, highlighting shared inflammatory pathways as potential therapeutic targets.<\/jats:p>","DOI":"10.2340\/aos.v85.45706","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:41:53Z","timestamp":1777527713000},"page":"212-218","source":"Crossref","is-referenced-by-count":0,"title":["Association of Crohn\u2019s disease with periodontal disease risk and severity: a meta-analytic study"],"prefix":"10.2340","volume":"85","author":[{"given":"Yanyan","family":"Jin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songhai","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidong","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijia","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1183","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"153559","unstructured":"Neophytou K, Tanwar S, Smith J. 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Nat Rev Gastroenterol Hepatol. 2019;16(10):597\u2013610."},{"key":"153565","unstructured":"Baima G, Manfredini R, Castellani R, Tonetti M. Periodontal inflammation as a systemic contributor in chronic inflammatory diseases. J Clin Periodontol. 2023;50(4):345\u201356."},{"key":"153566","unstructured":"Bertl K, Wimmer G, Schlagenhauf U, Pischon N. Clinical \u00adperiodontitis: pathogenesis, diagnosis, and treatment. Periodontology 2000. 2022;88(1):23\u201344."},{"key":"153567","unstructured":"Preshaw PM, Alba AL, Herrera D, Jepsen S, Konstantinidis A, Makrilakis K, et al. Periodontitis and systemic health: current status. J Clin Periodontol. 2012;39(Suppl. 12):1\u201312."},{"key":"153568","doi-asserted-by":"crossref","unstructured":"Hajishengallis G. Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol. 2015;15(1):30\u201344.","DOI":"10.1038\/nri3785"},{"key":"153569","unstructured":"Kaye EK, Chen N, Barasch A. Oral health and systemic inflammation. 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Crohn\u2019s disease: systemic inflammation and oral health implications. Gastroenterol Res Pract. 2015;2015:932581."},{"key":"153579","doi-asserted-by":"crossref","unstructured":"Greenhalgh T, Peacock R. Effectiveness and efficiency of search methods in systematic reviews of complex evidence: audit of primary sources. BMJ. 2005;331(7524):1064\u20135.","DOI":"10.1136\/bmj.38636.593461.68"},{"key":"153580","unstructured":"OpenGrey. System for information on grey literature in Europe [Internet]. 2025 [cited 2025 Aug 28]. Available from: http:\/\/www.opengrey.eu"},{"key":"153581","unstructured":"ProQuest Dissertations & Theses Global [Internet]. 2025 [cited 2025 Aug 28]. Available from: https:\/\/www.proquest.com\/products-services\/dissertations\/"},{"key":"153582","unstructured":"Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions (Version 5.1.0). 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J Inflamm Res. 2024;17:451\u201367."},{"key":"153596","unstructured":"Kim S, Park J, Lee H. Cross-sectional assessment of periodontitis in Crohn\u2019s disease. J Clin Periodontol. 2020;47(9):1123\u201332."},{"key":"153597","unstructured":"Gonzalez M, Rodriguez L, Perez E. Case-control study on oral health in Crohn\u2019s disease patients. BMC Oral Health. 2018;18:105."},{"key":"153598","unstructured":"Singh A, Kumar R, Sharma P. Cohort study on periodontal outcomes in inflammatory bowel disease. J Periodontol. 2019;90(6):679\u201388."},{"key":"153599","unstructured":"Thompson L, Adams J. Standardization of Crohn\u2019s disease diagnostic \u00adcriteria in epidemiologic research. Clin Gastroenterol. 2015;9(3):210\u201318."},{"key":"153600","unstructured":"Kozak J, Nowak P, Paszynska E. Clinical attachment loss as a diagnostic criterion for periodontitis. J Clin Periodontol. 2019;46(12):1234\u201342."},{"key":"153601","unstructured":"Paszynska E, Kozak J, Nowak P. 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