{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:05:44Z","timestamp":1779361544362,"version":"3.51.4"},"reference-count":34,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AOS"],"abstract":"<jats:p>Objectives: This study investigated the association between miR-146a-3p rs2910164 polymorphism and peri-implantitis (PI) susceptibility in the Han Chinese population, as well as the potential mechanisms underlying PI progression.\nMaterial and Methods: 183 PI patients and 219 individuals with healthy implants were enrolled. Quantitative polymerase chain reaction was used to detect miR-146a-3p expression levels and analyze the impact of rs2910164 genotypes on these levels. The study compared the association between rs2910164 polymorphism and PI susceptibility, evaluated participants\u2019 periodontal health status, and predicted miR-146a-3p target genes via bioinformatics methods, followed by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Protein-Protein Interaction (PPI) enrichment analyses. The regulatory relationship between miR-146a-3p and ITBG7 was validated by dual luciferase assays.\nResults: miR-146a-3p expression was elevated in PI patients, with significantly higher levels in those carrying the CG\/GG genotypes of rs2910164. Additionally, the GG genotype and G allele of rs2910164 were more prevalent in PI patients, who also exhibited poorer periodontal status. The GG genotype and G allele were identified as risk factors for PI. miR-146a-3p may contribute to PI progression by regulating inflammation-related signaling pathways. The existence of miR-146a-3p and ITBG7 had a negative regulatory relationship.\nConclusion: The miR-146a-3p rs2910164 polymorphism holds promise as a potential biomarker for predicting PI occurrence. miR-146a-3p might modulate inflammation-related signaling pathways via ITBG7 and may play a role in the regulation of PI progression.<\/jats:p>","DOI":"10.2340\/aos.v85.45995","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T10:15:54Z","timestamp":1779358554000},"page":"265-274","source":"Crossref","is-referenced-by-count":0,"title":["Impact of miR-146a-3p rs2910164 polymorphism on peri-implantitis susceptibility and target gene-mediated inflammatory responses"],"prefix":"10.2340","volume":"85","author":[{"given":"Yajun","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaofan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeneng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinhua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1183","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"156284","doi-asserted-by":"crossref","unstructured":"Wei X, Qian S, Yang Y, Mo J. Microbiome-based therapies for periodontitis and peri-implantitis. Oral Dis. 2024;30(5):2838\u201357.","DOI":"10.1111\/odi.14782"},{"key":"156285","doi-asserted-by":"crossref","unstructured":"Chen X, Zhao Y. Genetic involvement in dental implant failure: association with polymorphisms of genes modulating inflammatory responses and bone metabolism. J Oral Implantol. 2019;45(4):318\u201326.","DOI":"10.1563\/aaid-joi-D-18-00212"},{"key":"156286","doi-asserted-by":"crossref","unstructured":"Dopytalska K, Czaplicka A, Szyma\u0144ska E, Walecka I. The essential role of microRNAs in inflammatory and autoimmune skin diseases \u2013 a review. Int J Mol Sci. 2023;24(11):9130.","DOI":"10.3390\/ijms24119130"},{"key":"156287","doi-asserted-by":"crossref","unstructured":"Palideh A, Vaghari-Tabari M, Nosrati Andevari A, Qujeq D, Asemi Z, Alemi F, et al. MicroRNAs and periodontal disease: helpful therapeutic targets? 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Periodontology 2000. 2022;90(1):9\u201312.","DOI":"10.1111\/prd.12447"},{"key":"156291","doi-asserted-by":"crossref","unstructured":"Hamed MN, Abdulbaqi HR. Expression of miRNAs (146a and 155) in human peri-implant tissue affected by peri-implantitis: a case control study. BMC Oral Health. 2024;24(1):856.","DOI":"10.1186\/s12903-024-04579-x"},{"key":"156292","doi-asserted-by":"crossref","unstructured":"Ryan BM. microRNAs in cancer susceptibility. Adv Cancer Res. 2017;135:151\u201371.","DOI":"10.1016\/bs.acr.2017.06.004"},{"key":"156293","doi-asserted-by":"crossref","unstructured":"Kotlarek M, Kubiak A, Czetwerty\u0144ska M, \u015awierniak M, Gierlikowski W, Kolanowska M, et al. The rs2910164 genetic variant of miR-146a-3p is associated with increased overall mortality in patients with follicular variant papillary thyroid carcinoma. 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Association between polymorphisms in pre-miRNA genes and risk of oral squamous cell cancer in a Chinese population. PLoS One. 2017;12(6):e0176044.","DOI":"10.1371\/journal.pone.0176044"},{"key":"156298","doi-asserted-by":"crossref","unstructured":"Keewan E, Naser SA. MiR-146a rs2910164 G > C polymorphism modulates Notch-1\/IL-6 signaling during infection: a possible risk factor for Crohn\u2019s disease. Gut Pathogens. 2020;12:48.","DOI":"10.1186\/s13099-020-00387-0"},{"key":"156299","doi-asserted-by":"crossref","unstructured":"Ghorab RA, Fouad SH, Sherief AF, El-Sehsah EM, Shamloul S, Taha SI. MiR-146a (rs2910164) gene polymorphism and its impact on circulating MiR-146a levels in patients with inflammatory bowel diseases. Inflammation. 2024;48(3):1193-1205.","DOI":"10.1007\/s10753-024-02108-0"},{"key":"156300","doi-asserted-by":"crossref","unstructured":"Turkmen M, Firatli E. The study of genetic predisposition on periodontitis and peri-implantitis. 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