{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:05:37Z","timestamp":1784189137039,"version":"3.55.0"},"reference-count":43,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AOS"],"abstract":"<jats:p>Objective: To investigate whether baseline periodontal condition predicts reduced insulin sensitivity (RIS) over a follow-up period of about 15 years among participants with baseline euglycemia.\nMaterial and methods: A subpopulation (n = 224) of the Oulu1935 cohort was studied. Periodontal condition was defined by the presence and number of sites with periodontal pockets (probing pocket depth \u2265 4 mm) or by the participant being edentulous. Insulin sensitivity was measured using the Quantitative Insulin Sensitivity Check Index, with the lowest tertile indicating RIS. Rate ratios (RRs) with 95% confidence intervals (CI) were estimated using Poisson regression models with a robust error variance.\nResults: RIS was observed in 21.3% of the dentate participants without periodontal pockets, 32.8% of those with 1\u20136 sites with pockets, 33.3% of those with \u2265\u20097 sites with pockets, and 40.8% of the edentulous participants. Furthermore, adjusted RRs with 95% CIs (in parentheses) for the association of periodontal condition with RIS (reference: dentate participants without periodontal pockets) were 1.4 (0.8\u20132.6), 1.1 (0.6\u20132.1), and 1.4 (0.8\u20132.7), respectively.\nConclusions: Poor periodontal condition and edentulousness predicted RIS. A healthy periodontium appears to support normal insulin function, but further studies are needed.<\/jats:p>","DOI":"10.2340\/aos.v85.46514","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T07:26:36Z","timestamp":1784186796000},"page":"434-444","source":"Crossref","is-referenced-by-count":0,"title":["Association of periodontal condition with insulin sensitivity \u2013 results of the Oulu1935 cohort study"],"prefix":"10.2340","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5577-1599","authenticated-orcid":false,"given":"Ville","family":"Myllym\u00e4ki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1957-7577","authenticated-orcid":false,"given":"Pekka","family":"Yl\u00f6stalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Liisa","family":"Suominen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Knuuttila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla","family":"Rajala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1218-6925","authenticated-orcid":false,"given":"Sirkka","family":"Kein\u00e4nen-Kiukaanniemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4806-0800","authenticated-orcid":false,"given":"Sirpa","family":"Anttila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6855-7425","authenticated-orcid":false,"given":"Tuomas","family":"Saxlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"162688","doi-asserted-by":"crossref","unstructured":"Krzymien J, Ladyzynski P. 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