{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:59:38Z","timestamp":1785513578364,"version":"3.56.0"},"reference-count":46,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AOS"],"abstract":"<jats:p>Objective: (1) To survey oral health in fibromyalgia (FM) and compare with population controls and (2) to assess whether patterns of contact allergy are related to oral status in FM.\nMaterials and methods: Participants: 60 females with FM who had previously received contact allergy testing. Controls: 120 age- and gender-matched individuals. Questionnaire on aspects of oral health and symptoms and Oral Health Impact Profile-14. Clinical and radiological examination regarding oral health status.\nResults: The degree of periodontal disease differed significantly between the FM and control groups (p = 0.017), with the difference most marked in younger patients. No difference was seen regarding dental caries and filled surfaces. FM patients had a higher prevalence of oral lesions than control patients (30.0% vs. 10.1%, p &lt; 0.001). Younger FM patients had a poorer oral health-related quality of life than older patients. There was no relationship between oral symptoms or oral lesions and contact allergy.\nConclusions: Patients with FM have a poorer oral status than controls, particularly concerning periodontitis and oral lesions. Further work is required to assess whether contact allergy may play a role in poorer oral status and systemic inflammation in FM.<\/jats:p>","DOI":"10.2340\/aos.v85.46621","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:16:21Z","timestamp":1785510981000},"page":"511-519","source":"Crossref","is-referenced-by-count":0,"title":["Increased risk of periodontal disease and poor oral-related quality of life in fibromyalgia"],"prefix":"10.2340","volume":"85","author":[{"given":"Katharine","family":"Hopkins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Ahlgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5sa","family":"Wahlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annarita","family":"Antelmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Svedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"164373","doi-asserted-by":"crossref","unstructured":"Hauser W, Brahler E, Ablin J, Wolfe F. Modified 2016 American College of Rheumatology fibromyalgia criteria, the analgesic, anesthetic, and addiction clinical trial translations innovations opportunities and networks-American Pain Society Pain Taxonomy, and the prevalence of fibromyalgia. Arthritis Care Res. 2021;73:617\u201325.","DOI":"10.1002\/acr.24202"},{"key":"164374","doi-asserted-by":"crossref","unstructured":"Sarzi-Puttini P, Giorgi V, Marotto D, Atzeni F. Fibromyalgia: an update on clinical characteristics, aetiopathogenesis and treatment. Nat Rev Rheumatol. 2020;16:645\u201360.","DOI":"10.1038\/s41584-020-00506-w"},{"key":"164375","unstructured":"Rhodus NL, Fricton J, Carlson P, Messner R. Oral symptoms associated with fibromyalgia syndrome. J Rheumatol. 2003;30:1841\u20135."},{"key":"164376","doi-asserted-by":"crossref","unstructured":"De Stefano R, Bruno A, Muscatello MRA, Cedro C, Cicciu A, Rullo R, et al. Oral health and fibromyalgia syndrome: a systemic review. J Funct Morphol Kinesiol. 2020;5:7.","DOI":"10.3390\/jfmk5010007"},{"key":"164377","doi-asserted-by":"crossref","unstructured":"Antelmi A, Dahlin J, Hopkins K, Svedman C, Bruze M. Contact allergy to gold simultaneously patch tested in two different chambers. Contact Dermatitis. 2023;89:54\u20136.","DOI":"10.1111\/cod.14310"},{"key":"164378","doi-asserted-by":"crossref","unstructured":"Bruze M, Hopkins K, Dahlin J, Olsson K, Astrand J, Svedman C, et al. Increased rates of fragrance allergy in fibromyalgia individuals tested with the Swedish baseline patch test series. J Eur Acad Dermatol Venereol. 2023;37:104\u201313.","DOI":"10.1111\/jdv.18562"},{"key":"164379","doi-asserted-by":"crossref","unstructured":"Hopkins K, Antelmi A, Dahlin J, Olsson K, Svedman C, Astrand J, et al. Increased rates of gold and acrylate allergy in individuals with fibromyalgia tested with an extended dental patch test series. Acta Derm Venereol. 2023;103:adv22336.","DOI":"10.2340\/actadv.v103.22336"},{"key":"164380","doi-asserted-by":"crossref","unstructured":"Hopkins K, Antelmi A, Dahlin J, Olsson K, Svedman C, Astrand J, et al. Clinical relevance of contact allergy to gold sodium thiosulphate in fibromyalgia. Acta Derm Venereol. 2025;105:adv42463.","DOI":"10.2340\/actadv.v105.42463"},{"key":"164381","doi-asserted-by":"crossref","unstructured":"Pongpairoj K, Ale I, Andersen KE, Bruze M, Diepgen TL, Elsner PU, et al. Proposed ICDRG classification of the clinical presentation of contact allergy. Dermatitis. 2016;27:248\u201358.","DOI":"10.1097\/DER.0000000000000222"},{"key":"164382","doi-asserted-by":"crossref","unstructured":"Ahnlide I, Ahlgren C, Bjorkner B, Bruze M, Lundh T, Moller H, et al. Gold concentration in blood in relation to the number of gold restorations and contact allergy to gold. Acta Odontol Scand. 2002;60:301\u20135.","DOI":"10.1080\/00016350260248283"},{"key":"164383","doi-asserted-by":"crossref","unstructured":"Ahlgren C, Ahnlide I, Bjorkner B, Bruze M, Liedholm R, Moller H, et al. Contact allergy to gold is correlated to dental gold. Acta Derm Venereol. 2002;82:41\u20134.","DOI":"10.1080\/000155502753600876"},{"key":"164384","doi-asserted-by":"crossref","unstructured":"Malinauskiene L, Isaksson M, Bruze M. Systemic contact dermatitis in a gold-allergic patient after treatment with an oral homeopathic drug. J Am Acad Dermatol. 2013;68:e58.","DOI":"10.1016\/j.jaad.2012.09.013"},{"key":"164385","doi-asserted-by":"crossref","unstructured":"M\u00f6ller H, Bj\u00f6rkner B, Bruze M. Clinical reactions to systemic provocation with gold sodium thiomalate in patients with contact allergy to gold. Br J Dermatol. 1996;135:423\u20137.","DOI":"10.1111\/j.1365-2133.1996.tb01507.x"},{"key":"164386","unstructured":"Norderyd O, Kochi G, Papias A, K\u00f6hler AA, Helkimo AN, Brahm CO, et al. Oral health of individuals aged 3\u201380 years in J\u00f6nk\u00f6ping, Sweden, during 40 years (1973\u20132013). I. Review of findings on oral care habits and knowledge of oral health. Swed Dent J. 2015;39:57\u201368."},{"key":"164387","unstructured":"Norderyd O, Kochi G, Papias A, K\u00f6hler AA, Helkimo AN, Brahm CO, et al. Oral health of individuals aged 3\u201380 years in J\u00f6nk\u00f6ping, Sweden during 40 years (1973\u20132013). II. Review of clinical and radiographic findings. Swed Dent J. 2015;39:69\u201386."},{"key":"164388","unstructured":"Hugoson A, Koch G. Oral health in 1000 individuals aged 3\u201370 years in the community of J\u00f6nk\u00f6ping, Sweden. A review. Swed Dent J. 1979;3:69\u201387."},{"key":"164389","doi-asserted-by":"crossref","unstructured":"Slade GD. Derivation and validation of a short-form oral health impact profile. Community Dent Oral Epidemiol. 1997;25:284\u201390.","DOI":"10.1111\/j.1600-0528.1997.tb00941.x"},{"key":"164390","doi-asserted-by":"crossref","unstructured":"Larsson P, John MT, Hakeberg M, Nilner K, List T. General population norms of the Swedish short forms of oral health impact profile. J Oral Rehabil. 2014;41:275\u201381.","DOI":"10.1111\/joor.12137"},{"key":"164391","unstructured":"World Health Organization. Oral health surveys: basic methods. 5th ed. Geneva: World Health Organization; 2013."},{"key":"164392","unstructured":"Koch G. Effect of sodium fluoride in dentifrice and mouth wash on incidence of dental caries in schoolchildren. Odontol Revy. 1967;18:72\u20136."},{"key":"164393","doi-asserted-by":"crossref","unstructured":"Hugoson A, Jordan T. Frequency distribution of individuals aged 20\u201370 years according to severity of periodontal disease. Community Dent Oral Epidemiol. 1982;10:187\u201392.","DOI":"10.1111\/j.1600-0528.1982.tb00377.x"},{"key":"164394","doi-asserted-by":"crossref","unstructured":"Rodriguez-Pinto I, Agmon-Levin N, Howard A, Shoenfeld Y. Fibromyalgia and cytokines. Immunol Lett. 2014;161:200\u20133.","DOI":"10.1016\/j.imlet.2014.01.009"},{"key":"164395","doi-asserted-by":"crossref","unstructured":"Christidis N, Ghafouri B, Larsson A, Palstam A, Mannerkorpi K, Bileviciute-Ljungar I, et al. Comparison of the levels of pro-inflammatory cytokines released in the vastus lateralis muscle of patients with fibromyalgia and healthy controls during contractions of the quadriceps muscle \u2013 a microdialysis study. PLoS One. 2015;10:e0143856.","DOI":"10.1371\/journal.pone.0143856"},{"key":"164396","doi-asserted-by":"crossref","unstructured":"O\u2019Mahony LF, Srivastava A, Mehta P, Ciurtin C. Is fibromyalgia associated with a unique cytokine profile? A systematic review and meta-analysis. Rheumatology (Oxford). 2021;60:2602\u201314.","DOI":"10.1093\/rheumatology\/keab146"},{"key":"164397","doi-asserted-by":"crossref","unstructured":"Preshaw PM, Alba AL, Herrera D, Jepsen S, Konstantinidis A, Makrilakis K, et al. Periodontitis and diabetes: a two-way relationship. Diabetologia. 2012;55:21\u201331.","DOI":"10.1007\/s00125-011-2342-y"},{"key":"164398","doi-asserted-by":"crossref","unstructured":"Sanz M, Marco Del Castillo A, Jepsen S, Gonzalez-Juanatey JR, D\u2019Aiuto F, Bouchard P, et al. Periodontitis and cardiovascular diseases: consensus report. J Clin Periodontol. 2020;47:268\u201388.","DOI":"10.1111\/jcpe.13189"},{"key":"164399","doi-asserted-by":"crossref","unstructured":"Pischon N, Pischon T, Kroger J, Gulmez E, Kleber BM, Bernimoulin JP, et al. Association among rheumatoid arthritis, oral hygiene, and periodontitis. J Periodontol. 2008;79:979\u201386.","DOI":"10.1902\/jop.2008.070501"},{"key":"164400","unstructured":"Jepsen S, Caton JG, Albandar JM, Bissada NF, Bouchard P, Cortellini P, et al. Periodontal manifestations of systemic diseases and developmental and acquired conditions: consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Clin Periodontol. 2018;45(Suppl. 20):S219\u201329."},{"key":"164401","doi-asserted-by":"crossref","unstructured":"Nijakowski K, Gruszczynski D, Kolasinska J, Kopala D, Surdacka A. Periodontal disease in patients with psoriasis: a systematic review. Int J Environ Res Public Health. 2022;19:11302.","DOI":"10.3390\/ijerph191811302"},{"key":"164402","doi-asserted-by":"crossref","unstructured":"Ma KS, Lai JN, Veeravalli JJ, Chiu LT, Van Dyke TE, Wei JC. Fibromyalgia and periodontitis: bidirectional associations in population-based 15-year retrospective cohorts. J Periodontol. 2022;93:877\u201387.","DOI":"10.1002\/JPER.21-0256"},{"key":"164403","doi-asserted-by":"crossref","unstructured":"da Silva LA, Kazyiama HH, de Siqueira JT, Teixeira MJ, de Siqueira SR. High prevalence of orofacial complaints in patients with fibromyalgia: a case-control study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114:e29\u201334.","DOI":"10.1016\/j.oooo.2012.04.001"},{"key":"164404","doi-asserted-by":"crossref","unstructured":"Esteve M, Rosales-Leal JI. Analysis of temporomandibular disorders, bruxism and well-being in patients with fibromyalgia syndrome: a case-control study. J Oral Rehabil. 2025;52:350\u20136.","DOI":"10.1111\/joor.13908"},{"key":"164405","doi-asserted-by":"crossref","unstructured":"Hadler-Olsen E, Petrenya N, Jonsson B, Steingrimsdottir OA, Stubhaug A, Nielsen CS. Periodontitis is associated with decreased experimental pressure pain tolerance: the Tromso Study 2015\u20132016. J Clin Periodontol. 2024;51:874\u201383.","DOI":"10.1111\/jcpe.13968"},{"key":"164406","doi-asserted-by":"crossref","unstructured":"De Porras-Carrique T, Ramos-Garcia P, Aguilar-Diosdado M, Warnakulasuriya S, Gonzalez-Moles MA. Autoimmune disorders in oral lichen planus: a systematic review and meta-analysis. Oral Dis. 2023;29:1382\u201394.","DOI":"10.1111\/odi.14127"},{"key":"164407","doi-asserted-by":"crossref","unstructured":"Dave A, Shariff J, Philipone E. Association between oral lichen planus and systemic conditions and medications: case-control study. Oral Dis. 2021;27:515\u201324.","DOI":"10.1111\/odi.13572"},{"key":"164408","doi-asserted-by":"crossref","unstructured":"Jansson H, Wahlin A, Johansson V, Akerman S, Lundegren N, Isberg PE, et al. Impact of periodontal disease experience on oral health-related quality of life. J Periodontol. 2014;85:438\u201345.","DOI":"10.1902\/jop.2013.130188"},{"key":"164409","doi-asserted-by":"crossref","unstructured":"Diepgen TL, Ofenloch RF, Bruze M, Bertuccio P, Cazzaniga S, Coenraads PJ, et al. Prevalence of contact allergy in the general population in different European regions. Br J Dermatol. 2016;174:319\u201329.","DOI":"10.1111\/bjd.14167"},{"key":"164410","doi-asserted-by":"crossref","unstructured":"Uter W, Wilkinson SM, Aerts O, Bauer A, Borrego L, Brans R, et al. Patch test results with the European baseline series, 2019\/20-Joint European results of the ESSCA and the EBS working groups of the ESCD, and the GEIDAC. Contact Dermatitis. 2022;87:343\u201355.","DOI":"10.1111\/cod.14170"},{"key":"164411","doi-asserted-by":"crossref","unstructured":"Kucharczyk M, Slowik-Rylska M, Cyran-Stemplewska S, Gieron M, Nowak-Starz G, Krecisz B. Acrylates as a significant cause of allergic contact dermatitis: new sources of exposure. Postepy Dermatol Alergol. 2021;38:555\u201360.","DOI":"10.5114\/ada.2020.95848"},{"key":"164412","doi-asserted-by":"crossref","unstructured":"Raap U, Stiesch M, Reh H, Kapp A, Werfel T. Investigation of contact allergy to dental metals in 206 patients. Contact Dermatitis. 2009;60:339\u201343.","DOI":"10.1111\/j.1600-0536.2009.01524.x"},{"key":"164413","doi-asserted-by":"crossref","unstructured":"Forkel S, Schubert S, Corvin L, Heine G, Lang CCV, Oppel E, et al. Contact allergies to dental materials in patients. Br J Dermatol. 2024;190:895\u2013903.","DOI":"10.1093\/bjd\/ljad525"},{"key":"164414","doi-asserted-by":"crossref","unstructured":"Marcusson JA. Contact allergies to nickel sulfate, gold sodium thiosulfate and palladium chloride in patients claiming side-effects from dental alloy components. Contact Dermatitis. 1996;34:320\u20133.","DOI":"10.1111\/j.1600-0536.1996.tb02215.x"},{"key":"164415","doi-asserted-by":"crossref","unstructured":"Ahlgren C, Isaksson M, Moller H, Axell T, Liedholm R, Bruze M. The necessity of a test reading after 1 week to detect late positive patch test reactions in patients with oral lichen lesions. Clin Oral Investig. 2014;18:1525\u201331.","DOI":"10.1007\/s00784-013-1122-0"},{"key":"164416","doi-asserted-by":"crossref","unstructured":"Ahlgren C, Bruze M, Moller H, Gruvberger B, Axell T, Liedholm R, et al. Contact allergy to gold in patients with oral lichen lesions. Acta Derm Venereol. 2012;92:138\u201343.","DOI":"10.2340\/00015555-1247"},{"key":"164417","doi-asserted-by":"crossref","unstructured":"Ahlgren C, Axell T, Moller H, Isaksson M, Liedholm R, Bruze M. Contact allergies to potential allergens in patients with oral lichen lesions. Clin Oral Investig. 2014;18:227\u201337.","DOI":"10.1007\/s00784-013-0950-2"},{"key":"164418","unstructured":"Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, Fine DH, et al. Periodontitis: consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. 2018;89(Suppl. 1):S173\u201382."}],"container-title":["Acta Odontologica Scandinavica"],"original-title":[],"link":[{"URL":"https:\/\/medicaljournalssweden.se\/actaodontologica\/article\/download\/46621\/54962","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicaljournalssweden.se\/actaodontologica\/article\/download\/46621\/54962","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:16:27Z","timestamp":1785510987000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicaljournalssweden.se\/actaodontologica\/article\/view\/46621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":46,"URL":"https:\/\/doi.org\/10.2340\/aos.v85.46621","relation":{},"ISSN":["1502-3850","0001-6357"],"issn-type":[{"value":"1502-3850","type":"electronic"},{"value":"0001-6357","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,31]]}}}