{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:53:26Z","timestamp":1791550406545,"version":"4.3.4"},"reference-count":74,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AOS"],"abstract":"<jats:p>Objective: To compare systemic profiles, oral findings, and documented soft tissue healing between cancer and osteoporosis patients with medication-related osteonecrosis of the jaw (MRONJ).\nMaterial and methods: This retrospective single-center cohort included 105 cases treated in 2013\u20132019 (56 cancer; 49 osteoporosis). Healing at last follow-up was analyzed using adjusted logistic regression and Firth sensitivity analysis.\nResults: Of 102 cases with known final status, 68 had documented healing. Osteoporosis cases were older, predominantly female, and had longer antiresorptive exposure than cancer cases (76.7 \u00b1 11.1 vs. 70.0 \u00b1 8.5 years; 102.5 \u00b1 77.8 vs. 34.6 \u00b1 28.5 months; both p &lt; 0.001). Stage II predominated and Stage 0 was uncommon (3\/105, 2.9%). Previous tooth extraction at the MRONJ lesion site was more frequent in osteoporosis (95.9% vs. 71.4%; p &lt; 0.001). Surgical treatment was associated with higher healing odds (adjusted odds ratio [OR]: 11.12, 95% confidence interval [CI]: 4.12 to 33.35; p &lt; 0.001), whereas cancer indication was associated with lower odds (adjusted OR: 0.23, 95% CI: 0.07 to 0.68; p = 0.011).\nConclusions: Systemic profiles differed; oral patterns were similar. Non-random treatment and missing healing dates limit interpretation. Previous tooth extraction was the most frequent antecedent event; its indication and timing were unverified.<\/jats:p>","DOI":"10.2340\/aos.v85.46983","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:10:23Z","timestamp":1791547823000},"page":"713-724","source":"Crossref","is-referenced-by-count":0,"title":["Medication-related osteonecrosis of the jaw in cancer and osteoporosis patients: a retrospective seven-year single-center Norwegian cohort study of clinical profiles and documented soft tissue healing"],"prefix":"10.2340","volume":"85","author":[{"given":"Safiyye","family":"S\u00fcsl\u00fc","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5vard J.","family":"Haugen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tormod B.","family":"Kr\u00fcger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne Elin","family":"Reseland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente Brokstad","family":"Herlofson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"170887","doi-asserted-by":"crossref","unstructured":"Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, et al. 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Surgical management of medication-related osteonecrosis of the jaw is associated with improved disease resolution: a retrospective cohort study. J Oral Maxillofac Surg. 2019;77(9):1816\u201322.","DOI":"10.1016\/j.joms.2019.03.040"},{"key":"170908","doi-asserted-by":"crossref","unstructured":"Fujimori M, Toriyabe Y, Sakakibara N, Nojima M, Makino S; Hokkaido Association of Hospital Dentistry Medication-Related Osteonecrosis of the Jaw Research Group. What Affects Healing rates in patients treated for medication-related osteonecrosis of the jaw? The role of operative therapy and other clinical factors. J Oral Maxillofac Surg. 2024;82(11):1441\u201355.","DOI":"10.1016\/j.joms.2024.06.176"},{"key":"170909","doi-asserted-by":"crossref","unstructured":"Hadaya D, Soundia A, Freymiller E, Grogan T, Elashoff D, Tetradis S, et al. Nonsurgical management of medication-related osteonecrosis of the jaws using local wound care. 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Potential role of the comprehensive tooth extraction procedure in preventing medication related osteonecrosis of the jaw (MRONJ): a prospective cohort study. Orphanet J Rare Dis. 2025;20(1):619.","DOI":"10.1186\/s13023-025-04138-9"},{"key":"170923","doi-asserted-by":"crossref","unstructured":"Chang YS, Nanayakkara S, Yaacoub A, Cox SC. Prevention of medication-related osteonecrosis of the jaw: institutional insights from a retrospective study. Aust Dent J. 2025;70(1):70\u20137.","DOI":"10.1111\/adj.13050"},{"key":"170924","doi-asserted-by":"crossref","unstructured":"Catania G, Monaco F, Limberti G, Alessio M, De Martino I, Barile C, et al. Osteonecrosis of the jaws (ONJ) after bisphosphonate treatment in patients with multiple myeloma: decreasing ONJ incidence after adoption of preventive measures. 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