{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:55:37Z","timestamp":1785538537931,"version":"3.56.0"},"reference-count":22,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BIiD"],"abstract":"<jats:p>Purpose: The purpose of this study was to evaluate the effect of silver diamine fluoride (SDF) on microhardness and microleakage of composite and glass ionomer cement restorations.\nMaterials and methods: Cavities were prepared in 28 extracted teeth and restored according to four regimens (GIC, composite, GIC and SDF conditioned, composite and SDF conditioned). The restored teeth were thermocycled and autoclaved and then exposed to cariogenic challenge (inoculated with Lactobacillus acidophilus and Streptococcus mutans) for 30 days. The restored teeth were sectioned mesio-distally. One half was subjected to microleakage testing (dye penetration using 2% methylene blue) and the other to Vickers hardness test.\nResults: Group 4 SDF + Composite had the highest mean microleakage at 1.59 \u00b1 0.02 (mm), and Group 1 (GIC) and Group 3 (Composite) had the lowest mean microleakage (0.63 \u00b1 0.009 mm and 0.63 \u00b1 0.02 mm, respectively). The highest mean microhardness (HV) was observed in Group 3 (Composite) at 327 \u00b1 2.16 and lowest in Group 2 (GIC + SDF) at 283 \u00b1 1.95. Results were statistically significant with a p value &lt; 0.05.\nConclusion: SDF conditioning negatively impacted microhardness and increased microleakage, which could negatively impact the longevity of restorations. Therefore, in this study, SDF was not suitable as a treatment to decrease the occurrence of secondary caries.<\/jats:p>","DOI":"10.2340\/biid.v12.43074","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T09:05:51Z","timestamp":1739523951000},"page":"12-16","source":"Crossref","is-referenced-by-count":2,"title":["Addition of silver diamine fluoride to restorative materials: effect on microhardness and microleakage"],"prefix":"10.2340","volume":"12","author":[{"given":"Arshjot Singh","family":"Basra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Sedani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavannya","family":"Phaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Khetan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"99648","doi-asserted-by":"crossref","unstructured":"Gordan VV, Riley JL, Geraldeli S, Rindal DB, Qvist V, Fellows JL, et al. Repair or replacement of defective restorations by dentists in the dental practice-based research network. J Am Dent Assoc. 2012;143:593\u2013601. https:\/\/doi.org\/10.14219\/jada.archive.\u200b2012.0238","DOI":"10.14219\/jada.archive.2012.0238"},{"key":"99649","unstructured":"Mj\u00f6r IA, Toffenetti F. Secondary caries: a literature review with case reports. Quintessence Int [Internet]. 2000;31(3):165\u201379. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/11203922\/ [cited 21\/09\/2024]"},{"key":"99650","doi-asserted-by":"crossref","unstructured":"Sharma G. Approaches to arresting dental caries: an update. J Clin Diagn Res. 2015;9(5):ZE08\u201311. https:\/\/doi.org\/10.7860\/JCDR\/2015\/12774.5943","DOI":"10.7860\/JCDR\/2015\/12774.5943"},{"key":"99651","doi-asserted-by":"crossref","unstructured":"Giacaman RA, Mu\u00f1oz-Sandoval C, Neuhaus KW, Fontana M, Cha\u0142as R. Evidence-based strategies for the minimally invasive treatment of carious lesions: review of the literature. Adv Clin Exp Med. 2018;27:1009\u201316. https:\/\/doi.org\/10.17219\/acem\/77022","DOI":"10.17219\/acem\/77022"},{"key":"99652","doi-asserted-by":"crossref","unstructured":"Mei M-L, Chu C-H, Low K-H, Che C-M, Lo E-C-M. Caries arresting effect of silver diamine fluoride on dentine carious lesion with S. mutans and L. acidophilus dual-species cariogenic biofilm. Med Oral Patol Oral Cir Bucal. 2013;18(6):e824\u201331. https:\/\/doi.org\/10.4317\/medoral.18831","DOI":"10.4317\/medoral.18831"},{"key":"99653","doi-asserted-by":"crossref","unstructured":"Mei ML, Li Q, Chu C-H, Lo E-M, Samaranayake LP. Antibacterial effects of silver diamine fluoride on multi-species cariogenic biofilm on caries. Ann Clin Microbiol Antimicrob. 2013;12:4. https:\/\/doi.org\/10.1186\/1476-0711-12-4","DOI":"10.1186\/1476-0711-12-4"},{"key":"99654","doi-asserted-by":"crossref","unstructured":"Chu CH, Mei L, Seneviratne CJ, Lo ECM. 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Efficacy of silver diamine fluoride for caries reduction in primary teeth and first permanent molars of schoolchildren: 36-month clinical trial. J Dent Res. 2005;84:721\u20134. https:\/\/doi.org\/10.1177\/154405910508400807","DOI":"10.1177\/154405910508400807"},{"key":"99658","doi-asserted-by":"crossref","unstructured":"Mei ML, Zhao IS, Ito L, Lo EC-M, Chu C-H. Prevention of secondary caries by silver diamine fluoride. Int Dent J. 2016;66:71\u20137. https:\/\/doi.org\/10.1111\/idj.12207","DOI":"10.1111\/idj.12207"},{"key":"99659","doi-asserted-by":"crossref","unstructured":"Featherstone JDB. Remineralization, the natural caries repair process \u2013 the need for new approaches. Adv Dent Res. 2009;21:4\u20137. https:\/\/doi.org\/10.1177\/0895937409335590","DOI":"10.1177\/0895937409335590"},{"key":"99660","doi-asserted-by":"crossref","unstructured":"Mei ML, Ito L, Cao Y, Li QL, Lo ECM, Chu CH. Inhibitory effect of silver diamine fluoride on dentine demineralisation and collagen degradation. J Dent. 2013;41:809\u201317. https:\/\/doi.org\/10.1016\/j.jdent.2013.06.009","DOI":"10.1016\/j.jdent.2013.06.009"},{"key":"99661","doi-asserted-by":"crossref","unstructured":"Chu CH, Lo ECM. Microhardness of dentine in primary teeth after topical fluoride applications. J Dent. 2008;36:387\u201391. https:\/\/doi.org\/10.1016\/j.jdent.2008.02.013","DOI":"10.1016\/j.jdent.2008.02.013"},{"key":"99662","doi-asserted-by":"crossref","unstructured":"Lutgen P, Chan D, Sadr A. Effects of silver diammine fluoride on bond strength of adhesives to sound dentin. Dent Mater J. 2018;37:1003\u20139. https:\/\/doi.org\/10.4012\/dmj.2017-401","DOI":"10.4012\/dmj.2017-401"},{"key":"99663","doi-asserted-by":"crossref","unstructured":"Soeno K, Taira Y, Matsumura H, Atsuta M. Effect of desensitizers on bond strength of adhesive luting agents to dentin. 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