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Patient-reported outcomes were explored where reported.\nMaterials and methods: A systematic review was performed on relevant databases as PubMed, Cochrane, EBSCOhost and Scopus.\nResults: A total of 8 in vivo and 23 in vitro studies were included. Self-assembling peptide P11\u20134 (SAP P11\u20134) and chitosan-based materials demonstrated consistent remineralisation benefits, predominantly in laboratory studies, with limited supporting clinical evidence. Risk of bias was moderate for in vitro studies and low-to-some concerns for in vivo studies.\nConclusion: Self-assembling peptides and chitosan-based biomaterials show promising potential, though current evidence is largely laboratory-based and requires further clinical validation. Further well-designed clinical trials are warranted.<\/jats:p>","DOI":"10.2340\/biid.v13.45679","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:25:36Z","timestamp":1776263136000},"page":"239-251","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the remineralisation potential and clinical evidence of emerging biocompatible materials in restorative dentistry: a systematic review"],"prefix":"10.2340","volume":"13","author":[{"given":"Isaiselvi","family":"Duraiarasan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indumathi","family":"Kariannan Partheeban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibyl","family":"Siluvai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishnaprakash","family":"Govindaraj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1183","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"149653","doi-asserted-by":"crossref","unstructured":"Sekar R, Revanth MP, Marimuthu R, Siluvai S, Vadivelu S, Raghunathan D. 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