{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T07:07:06Z","timestamp":1784099226037,"version":"3.55.0"},"reference-count":46,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BIiD"],"abstract":"<jats:p>Background: Extrusion of root canal sealers into neurovascular tissues can result in rare but serious neurological complications, including paresthesia and neuropathic pain. This study aimed to evaluate the histopathological effects of direct peripheral nerve exposure to AH Plus\u00ae Bioceramic Sealer and to assess the influence of Stemregen\u00ae supplementation on histopathological tissue responses.\nMaterials and methods: Forty-eight male Sprague-Dawley rats were randomly assigned to four groups (n = 12): Control, Supplement only, Bioceramic only, and Bioceramic + Supplement. Sterile polyethylene tubes containing AH Plus\u00ae Bioceramic Sealer were applied in contact with the sciatic nerve in the relevant groups. Stemregen\u00ae was administered orally at 300 mg\/kg\/day for 15 days. At the end of the experiment, nerve tissues were harvested and examined histologically. Nerve tissues were evaluated histologically for axonal and myelin degeneration, inflammatory infiltration, fibrosis, and perineurial changes using semiquantitative scoring, and intergroup comparisons were performed using nonparametric statistical tests (Kruskal\u2013Wallis test followed by Dunn\u2019s post hoc analysis).\nResults: Severe axonal degeneration, inflammation, and fibrosis were observed in the Bioceramic group compared to controls (p &lt; 0.05). The Bioceramic + Supplement group showed lower histological damage scores than the Bioceramic-only group; however, these differences were not statistically significant (p &gt; 0.05).\nConclusions: These findings indicate that direct exposure to a bioceramic root canal sealer is associated with histopathological alterations in peripheral nerve tissue, whereas systemic administration of Stemregen\u00ae was associated with lower injury scores without achieving statistical significance.<\/jats:p>","DOI":"10.2340\/biid.v13.46483","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T13:46:45Z","timestamp":1783518405000},"page":"571-582","source":"Crossref","is-referenced-by-count":0,"title":["Short-term histopathological effects of direct peripheral nerve exposure to AH Plus\u00ae Bioceramic Sealer in rats: an exploratory assessment of Stemregen\u00ae supplementation"],"prefix":"10.2340","volume":"13","author":[{"given":"Haydar \u0130rfan","family":"Y\u00fccel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mevl\u00fct Sinan","family":"Ocak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebru","family":"G\u00f6kdere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serkan","family":"Dundar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130brahim Hanifi","family":"\u00d6zercan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"162265","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2006.03.022"},{"key":"162266","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(82)80265-3"},{"key":"162267","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(97)80303-2"},{"key":"162268","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.07.015"},{"key":"162269","unstructured":"Gallas-Torreira MM, Reboiras-L\u00f3pez MD, Garc\u00eda-Garc\u00eda A, G\u00e1ndara-Rey J. 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