{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T12:30:15Z","timestamp":1786624215578,"version":"build-2736575974"},"reference-count":42,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BIiD"],"abstract":"<jats:p>Objective: To compare the clinical and radiographic outcomes of NeoPUTTY and mineral trioxide aggregate (MTA) as medicaments for full pulpotomy in mature permanent molars with irreversible pulpitis in children.\nMaterials and Methods: Forty-six mature permanent molars from 46 children aged 9\u201314 years (one tooth per child) were randomly allocated to NeoPUTTY (n = 23) or MTA (n = 23) groups. Full pulpotomy was performed under rubber dam isolation followed by immediate composite restoration. Clinical and radiographic outcomes were evaluated at 1, 3, 6, and 12 months and at 6 and 12 months, respectively. Postoperative pain was assessed at 24 h using a visual analog scale (VAS). Hemostasis time was recorded intraoperatively. Per-protocol analysis was performed using an independent t-test, Mann\u2013Whitney U test, Chi-square test, and Fisher\u2019s exact test (p &lt; 0.05). The trial was registered on ClinicalTrials.gov (NCT07702942).\nResults: Forty-four teeth (22 per group) completed the final analysis; one participant from each group was lost to follow-up. Mean VAS scores decreased significantly within 24 h in both groups (p &lt; 0.001), from 6.48 \u00b1 1.73 to 0.91 \u00b1 1.12 (NeoPUTTY) and from 6.17 \u00b1 1.47 to 0.65 \u00b1 0.78 (MTA), with no significant intergroup difference. Overall success at 12 months was 95.5% in both groups (21\/22; 95% confidence interval [CI]: 77.2\u201399.9; p = 1.000). Intra- and inter-examiner radiographic agreement was almost perfect (\u03ba = 0.87 and 0.83). Treatment outcome was not significantly associated with jaw location, sex, pain duration, hemostasis time, caries depth, or Wolters pulpitis grade.\nConclusion: Within the limitations of this study and 12-month follow-up, no statistically significant differences were detected between NeoPUTTY and MTA in postoperative pain reduction or clinical\/radiographic success after full pulpotomy in mature permanent molars with irreversible pulpitis. Adequately powered non-inferiority or equivalence trials with longer follow-up are required to confirm these preliminary findings.<\/jats:p>","DOI":"10.2340\/biid.v13.46677","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T11:43:14Z","timestamp":1786621394000},"page":"664-673","source":"Crossref","is-referenced-by-count":0,"title":["Comparative evaluation of NeoPUTTY and mineral trioxide aggregate for full pulpotomy in mature permanent molars with irreversible pulpitis: a randomized clinical study"],"prefix":"10.2340","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0003-5272","authenticated-orcid":false,"given":"Shiwani","family":"Chawla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5514-2482","authenticated-orcid":false,"given":"Ruchi","family":"Singhal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3788-5298","authenticated-orcid":false,"given":"Ritu","family":"Namdev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6352-1149","authenticated-orcid":false,"given":"Chanchal","family":"Kumari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6721-4440","authenticated-orcid":false,"given":"Khusboo","family":"Chhanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1183","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"165813","unstructured":"Rathee M, Sapra A. Dental caries. In: StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing; 2025 [updated 2023 Jun 21; cited 2026 May 19]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK551699\/"},{"key":"165814","doi-asserted-by":"crossref","unstructured":"Farges JC, Alliot-Licht B, Renard E, Ducret M, Gaudin A, Smith AJ, et al. Dental pulp defence and repair mechanisms in dental caries. Mediators Inflamm. 2015;2015:230251.","DOI":"10.1155\/2015\/230251"},{"key":"165815","unstructured":"American Association of Endodontists. Glossary of endodontic terms. 10th ed. Chicago, IL: American Association of Endodontists; 2019 [updated 2020 Mar; cited 2026 May 19]. Available from: https:\/\/www.aae.org\/specialty\/clinical-resources\/glossary-endodontic-terms\/"},{"key":"165816","doi-asserted-by":"crossref","unstructured":"Ricucci D, Loghin S, Siqueira JF, Jr. Correlation between clinical and histologic pulp diagnoses. J Endod. 2014;40(12):1932\u20139.","DOI":"10.1016\/j.joen.2014.08.010"},{"key":"165817","doi-asserted-by":"crossref","unstructured":"Wolters WJ, Duncan HF, Tomson PL, Karim IE, McKenna G, Dorri M, et al. Minimally invasive endodontics: a new diagnostic system for assessing pulpitis and subsequent treatment needs. Int Endod J. 2017;50(9):825\u20139.","DOI":"10.1111\/iej.12793"},{"key":"165818","doi-asserted-by":"crossref","unstructured":"Hirschberg CS, Bogen G, Galicia JC, Lemon RR, Peters OA, Ruparel NB, et al. AAE position statement on vital pulp therapy. J Endod. 2021;47:1340\u20134.","DOI":"10.1016\/j.joen.2021.07.015"},{"key":"165819","doi-asserted-by":"crossref","unstructured":"European Society of Endodontology (ESE) developed by: Duncan HF, Galler KM, Tomson PL, Simon S, El-Karim I, Kundzina R, et al. European Society of Endodontology position statement: management of deep caries and the exposed pulp. Int Endod J. 2019;52(7):923\u201334.","DOI":"10.1111\/iej.13080"},{"key":"165820","doi-asserted-by":"crossref","unstructured":"Sadaf D. Success of coronal pulpotomy in permanent teeth with irreversible pulpitis: an evidence-based review. Cureus. 2020;12(1):e6747.","DOI":"10.7759\/cureus.6747"},{"key":"165821","doi-asserted-by":"crossref","unstructured":"Cervino G, Laino L, D\u2019Amico C, Russo D, Nucci L, Amoroso G, et al. Mineral trioxide aggregate applications in endodontics: a review. Eur J Dent. 2020;14(4):683\u201391.","DOI":"10.1055\/s-0040-1713073"},{"key":"165822","doi-asserted-by":"crossref","unstructured":"Parirokh M, Torabinejad M. Mineral trioxide aggregate: a comprehensive literature review \u2013 part III: clinical applications, drawbacks, and mechanism of action. J Endod. 2010;36(3):400\u201313.","DOI":"10.1016\/j.joen.2009.09.009"},{"key":"165823","doi-asserted-by":"crossref","unstructured":"Pushpalatha C, Dhareshwar V, Sowmya SV, Augustine D, Vinothkumar TS, Renugalakshmi A, et al. Modified mineral trioxide aggregate \u2013 a versatile dental material: an insight on applications and newer advancements. Front Bioeng Biotechnol. 2022;10:941826.","DOI":"10.3389\/fbioe.2022.941826"},{"key":"165824","doi-asserted-by":"crossref","unstructured":"Debelian G, Trope M. The use of premixed bioceramic materials in endodontics. G Ital Endod. 2016;30(2):70\u201380.","DOI":"10.1016\/j.gien.2016.09.001"},{"key":"165825","unstructured":"Alqahtani AS, Alsuhaibani NN, Sulimany AM, Bawazir OA. NeoPUTTY\u00ae versus NeoMTA 2\u00ae as a pulpotomy medicament for primary molars: a randomized clinical trial. Pediatr Dent. 2023;45(3):240\u20134."},{"key":"165826","unstructured":"NuSmile. NeoPUTTY frequently asked questions. Houston, TX: NuSmile Ltd. [cited 2026 May 19]. Available from: https:\/\/www.nusmile.com\/site\/assets\/files\/NuSmile_NeoPUTTY_FAQ.pdf"},{"key":"165827","doi-asserted-by":"crossref","unstructured":"Acharya S, Gurunathan D. Comparative evaluation of success of NeoPutty Mineral Trioxide Aggregate\u00ae with formocresol as pulpotomy medicaments in primary molars: a clinical study. Indian J Dent Res. 2024;35(2):170\u20135.","DOI":"10.4103\/ijdr.ijdr_730_23"},{"key":"165828","doi-asserted-by":"crossref","unstructured":"Talekar AL, Musale PK, Chaudhari GS, Silotry TMH, Waggoner WF. A prospective randomised clinical trial evaluating pulpotomy in primary molars with three bioceramic calcium silicate cements: 24 month \u00adfollow-up. Int J Paediatr Dent. 2025;35(4):763\u201373.","DOI":"10.1111\/ipd.13288"},{"key":"165829","doi-asserted-by":"crossref","unstructured":"Kothari P, Mathur A, Tirupathi S, Chauhan R, Nankar M, Suvarna A. Comparative clinical and radiographic success rate of bioceramic premix vs biosilicate-based medicament as indirect pulp treatment materials in primary molars: a double-blind randomized trial with a follow-up of 12 months. Int J Clin Pediatr Dent. 2024;17(7):748\u201353.","DOI":"10.5005\/jp-journals-10005-2871"},{"key":"165830","doi-asserted-by":"crossref","unstructured":"Acharya S, Gurunathan D, Assiry AA, Luke AM, Shetty KP, Karobari MI. Comparison of modified NeoPutty MTA\u00ae, biodentine, and calcium hydroxide in indirect pulp therapy in deciduous teeth: an in vivo clinical study. Int J Clin Pediatr Dent. 2024;17(9):1025\u20139.","DOI":"10.5005\/jp-journals-10005-2953"},{"key":"165831","doi-asserted-by":"crossref","unstructured":"Taha NA, Albakri SW. Outcome and prognostic factors for partial and full pulpotomy in the management of spontaneous symptomatic pulpitis in carious mature permanent teeth: a randomized clinical trial. J Endod. 2024;50(7):889\u201398.","DOI":"10.1016\/j.joen.2024.03.012"},{"key":"165832","doi-asserted-by":"crossref","unstructured":"Khorasanchi M, Gharechahi M, Azizi Z. Management of immature permanent mandibular first molar using NeoPutty: a case report. Clin Case Rep. 2025;13(10):e71302.","DOI":"10.1002\/ccr3.71302"},{"key":"165833","doi-asserted-by":"crossref","unstructured":"Acharya S, Sahoo D, Singh B, Gurunathan D. Revascularization revisited with modified triple antibiotic paste and NeoPutty MTA\u00ae. J Pharm Bioallied Sci. 2024;16(Suppl 2):S1871\u20134.","DOI":"10.4103\/jpbs.jpbs_1212_23"},{"key":"165834","doi-asserted-by":"crossref","unstructured":"Namaei Ghasemi S, Kheradmand Z, Moushekhian S, Ghasemi Z. Apical surgery of a maxillary left central tooth using NeoPutty after retreatment failure: a case report. Clin Case Rep. 2025;13(10):e71220.","DOI":"10.1002\/ccr3.71220"},{"key":"165835","doi-asserted-by":"crossref","unstructured":"Bj\u00f8rndal L, Simon S, Tomson PL, Duncan HF. Management of deep caries and the exposed pulp. Int Endod J. 2019;52(7):949\u201373.","DOI":"10.1111\/iej.13128"},{"key":"165836","unstructured":"Coll JA, Dhar V, Guelmann M, Crystal YO, Chen CY, Marghalani AA, et al. Guideline for use of vital pulp therapy in permanent teeth. Pediatr Dent. 2025;47(5):299\u2013311."},{"key":"165837","doi-asserted-by":"crossref","unstructured":"Delgado DA, Lambert BS, Boutris N, McCulloch PC, Robbins AB, Moreno MR, et al. Validation of digital visual analog scale pain scoring with a traditional paper-based visual analog scale in adults. J Am Acad Orthop Surg Glob Res Rev. 2018;2(3):e088.","DOI":"10.5435\/JAAOSGlobal-D-17-00088"},{"key":"165838","doi-asserted-by":"crossref","unstructured":"Kahler B, Taha NA, Lu J, Saoud TM. Vital pulp therapy for permanent teeth with diagnosis of irreversible pulpitis: biological basis and outcome. Aust Dent J. 2023;68 Suppl 1:S110\u201322.","DOI":"10.1111\/adj.12997"},{"key":"165839","doi-asserted-by":"crossref","unstructured":"Qudeimat MA, Alyahya A, Hasan AA. Mineral trioxide aggregate pulpotomy for permanent molars with clinical signs indicative of irreversible pulpitis: a preliminary study. Int Endod J. 2017;50(2):126\u201334.","DOI":"10.1111\/iej.12614"},{"key":"165840","doi-asserted-by":"crossref","unstructured":"Eghbal MJ, Asgary S, Baglue RA, Parirokh M, Ghoddusi J. MTA pulpotomy of human permanent molars with irreversible pulpitis. Aust Endod J. 2009;35(1):4\u20138.","DOI":"10.1111\/j.1747-4477.2009.00166.x"},{"key":"165841","doi-asserted-by":"crossref","unstructured":"Taha NA, Abdelkhader SZ. Outcome of full pulpotomy using Biodentine in adult patients with symptoms indicative of irreversible pulpitis. Int Endod J. 2018;51(8):819\u201328.","DOI":"10.1111\/iej.12903"},{"key":"165842","doi-asserted-by":"crossref","unstructured":"Galani M, Tewari S, Sangwan P, Mittal S, Kumar V, Duhan J. Comparative evaluation of postoperative pain and success rate after pulpotomy and root canal treatment in cariously exposed mature permanent molars: a randomized controlled trial. J Endod. 2017;43(12):1953\u201362.","DOI":"10.1016\/j.joen.2017.08.007"},{"key":"165843","doi-asserted-by":"crossref","unstructured":"Aguilar P, Linsuwanont P. Vital pulp therapy in vital permanent teeth with cariously exposed pulp: a systematic review. J Endod. 2011;37(5):581\u20137.","DOI":"10.1016\/j.joen.2010.12.004"},{"key":"165844","doi-asserted-by":"crossref","unstructured":"Cushley S, Duncan HF, Lappin MJ, Tomson PL, Lundy FT, Cooper P, et al. Pulpotomy for mature carious teeth with symptoms of irreversible pulpitis: a systematic review. J Dent. 2019;88:103158.","DOI":"10.1016\/j.jdent.2019.06.005"},{"key":"165845","doi-asserted-by":"crossref","unstructured":"Ather A, Patel B, Gelfond JAL, Ruparel NB. Outcome of pulpotomy in permanent teeth with irreversible pulpitis: a systematic review and meta-analysis. Sci Rep. 2022;12(1):19664.","DOI":"10.1038\/s41598-022-20918-w"},{"key":"165846","doi-asserted-by":"crossref","unstructured":"Chawla S, Singhal R, Namdev R, Kumar A, Chhanna K, Kumari C. Effectiveness of pulpotomy compared with pulpectomy for irreversible pulpitis in primary teeth: a systematic review and meta-analysis. J Dent. 2026;166:106329.","DOI":"10.1016\/j.jdent.2026.106329"},{"key":"165847","doi-asserted-by":"crossref","unstructured":"Sabbagh S, Bahrololoomi Z, Sarraf Shirazi A, Zarebidoki F, Salajegheh S, Fotouhi F, et al. Comparative evaluation of cervical pulpotomy and pulpectomy for primary molars with irreversible pulpitis: a multicentre randomised controlled trial. Eur Arch Paediatr Dent. 2024;25(2):255\u201365.","DOI":"10.1007\/s40368-024-00880-z"},{"key":"165848","doi-asserted-by":"crossref","unstructured":"Hu X, Liang Z, Wang Q, Liu L. A retrospective study of iRoot BP Plus pulpotomy compared with Vitapex pulpectomy for irreversible pulpitis of primary molars with the presence of coronal pulp tissue. Int J Paediatr Dent. 2023;33(2):216\u201326.","DOI":"10.1111\/ipd.13037"},{"key":"165849","doi-asserted-by":"crossref","unstructured":"Ozdemir M, Oncu A. Penetration of Biodentine, NeoMTA 2, and NeoPUTTY into dentinal tubules in primary tooth pulpotomy: a confocal laser scanning microscopy analysis. BMC Oral Health. 2025;25(1):727.","DOI":"10.1186\/s12903-025-06065-4"},{"key":"#cr-split#-165850.1","doi-asserted-by":"crossref","unstructured":"Bogen G, Kim JS, Bakland LK. Direct pulp capping with mineral trioxide aggregate: an observational study. J Am Dent Assoc. 2008;139(3):305-15","DOI":"10.14219\/jada.archive.2008.0160"},{"key":"#cr-split#-165850.2","doi-asserted-by":"crossref","unstructured":"quiz 305-15. https:\/\/doi.org\/10.14219\/jada.archive.2008.0160 Erratum in: J Am Dent Assoc. 2008;139(5):541.","DOI":"10.14219\/jada.archive.2008.0160"},{"key":"165851","doi-asserted-by":"crossref","unstructured":"Linsuwanont P, Wimonsutthikul K, Pothimoke U, Santiwong B. Treatment outcomes of mineral trioxide aggregate pulpotomy in vital permanent teeth with carious pulp exposure: the retrospective study. J Endod. 2017;43(2):225\u201330.","DOI":"10.1016\/j.joen.2016.10.027"},{"key":"165852","doi-asserted-by":"crossref","unstructured":"Aldeen RZ, Aljabban O, Almanadili A, Alkurdi S, Eid A, Mancino D, et al. The influence of carious lesion and bleeding time on the success of partial pulpotomy in permanent molars with irreversible pulpitis: a prospective study. Bioengineering (Basel). 2023;10(6):700.","DOI":"10.3390\/bioengineering10060700"},{"key":"165853","doi-asserted-by":"crossref","unstructured":"Jim\u00e9nez-Mart\u00edn C, Mart\u00edn-Gonz\u00e1lez J, Crespo-Gallardo I, Montero-Miralles P, Cabanillas-Balsera D, Segura-Egea JJ. Elective full pulpotomy in mature permanent teeth diagnosed with symptomatic irreversible pulpitis: a two years retrospective study. Clin Oral Investig. 2024;28(8):421.","DOI":"10.1007\/s00784-024-05814-z"}],"container-title":["Biomaterial Investigations in Dentistry"],"original-title":[],"link":[{"URL":"https:\/\/medicaljournalssweden.se\/biid\/article\/download\/46677\/55167","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicaljournalssweden.se\/biid\/article\/download\/46677\/55167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T11:43:36Z","timestamp":1786621416000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicaljournalssweden.se\/biid\/article\/view\/46677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":42,"URL":"https:\/\/doi.org\/10.2340\/biid.v13.46677","relation":{},"ISSN":["2641-5275"],"issn-type":[{"value":"2641-5275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]}}}