{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T14:15:36Z","timestamp":1771683336185,"version":"3.50.1"},"reference-count":0,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JRM-CC"],"abstract":"<jats:p>Objective: Immune-mediated necrotising myopathy associated with anti-signal recognition particle antibodies is a rare and debilitating condition characterised by significant muscle weakness and resultant disability. There are no established guidelines for safe and effective rehabilitation programmes for patients diagnosed with myopathy.\r\nCase Report: A 42-year-old woman presented with subacute onset symmetrical proximal upper and lower limb weakness and dysphagia. She was diagnosed with Anti-SRP immune-mediated necrotising myopathy and was promptly initiated on aggressive immunosuppressive therapy. Despite this, she had significant impairment in function, including the inability to ambulate.\r\nIntervention and Outcome: The patient underwent an intensive structured inpatient rehabilitation programme at our centre consisting of strength and endurance exercises combined with functional exercises. It also included the use of robot assisted gait training. All this resulted in major improvements in objective outcomes including Functional Independence Measure (FIM), Modified Barthel Index (MBI), 10-metre-walk test (10MWT) and 6-minute-walk test (6MWT) scores, and desirable functional outcomes. The program was well tolerated by the patient with no adverse events.\r\nConclusion: This case highlights the crucial role of a structured rehabilitation programme in the holistic management of a patient with Anti-SRP immune-mediated necrotising myopathy resulting in successful functional outcomes for the patient.<\/jats:p>","DOI":"10.2340\/jrm-cc.v7.40653","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T02:47:59Z","timestamp":1729219679000},"page":"jrmcc40653","source":"Crossref","is-referenced-by-count":3,"title":["Inpatient rehabilitation and functional outcome of a case of anti-SRP immune mediated necrotising myopathy"],"prefix":"10.2340","volume":"7","author":[{"given":"Nicole","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khin Yamin","family":"Thein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6623-6265","authenticated-orcid":false,"given":"San San","family":"Tay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1183","published-online":{"date-parts":[[2024,10,17]]},"container-title":["Journal of Rehabilitation Medicine - Clinical Communications"],"original-title":[],"link":[{"URL":"https:\/\/medicaljournalssweden.se\/jrm-cc\/article\/download\/40653\/47981","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicaljournalssweden.se\/jrm-cc\/article\/download\/40653\/47981","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T14:19:58Z","timestamp":1770128398000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicaljournals.se\/jrm\/content\/abstract\/10.2340\/jrm-cc.v7.40653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,17]]},"references-count":0,"URL":"https:\/\/doi.org\/10.2340\/jrm-cc.v7.40653","relation":{},"ISSN":["2003-0711"],"issn-type":[{"value":"2003-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,17]]}}}