{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T08:13:29Z","timestamp":1779264809251,"version":"3.51.4"},"reference-count":36,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JRM"],"abstract":"<jats:p>Objective: This study aimed to develop a decision tree-based model to identify prognostic patient profiles associated with discharge destination during intensive care unit admission.\nDesign: Historical cohort study using decision tree analysis.\nSubjects\/Patients: 300 critically ill patients selected from 857 intensive care unit admissions after applying exclusion criteria.\nMethods: The primary outcome was discharge destination (home vs non-home). Candidate variables included demographics, frailty, illness severity scores, delirium, ventilator duration, intensive care unit length of stay, and physical function on intensive care unit discharge. Terminal nodes were interpreted as prognostic profiles.\nResults: Decision tree analysis identified profiles based on Acute Physiology and Chronic Health Evaluation II score, intensive care unit length of stay, Functional Status Score for the Intensive Care Unit, and age. A profile with lower initial severity and prolonged stay was associated with non-home discharge (area under the curve 0.76). Conversely, a profile with higher initial severity, preserved functional mobility (Functional Status Score for the Intensive Care Unit \u2265\u20095), and age &lt;\u200980 years was associated with home discharge (area under the curve 0.77).\nConclusion: Combinations of illness severity, length of stay, functional status, and age-defined prognostic profiles were associated with discharge destination during intensive care unit admission.<\/jats:p>","DOI":"10.2340\/jrm.v58.44237","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:52:24Z","timestamp":1779263544000},"page":"jrm44237","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic profiles for discharge destination identified during intensive care unit admission: a decision tree analysis"],"prefix":"10.2340","volume":"58","author":[{"given":"Sho","family":"Otsubo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shota","family":"Okuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Kawamitsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shumpei","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1183","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"155807","doi-asserted-by":"crossref","unstructured":"Topp R, Ditmyer M, King K, Doherty K, Hornyak J 3rd. The effect of bed rest and potential of prehabilitation on patients in the intensive care unit. AACN Clin Issues 2002; 13: 263\u2013276.","DOI":"10.1097\/00044067-200205000-00011"},{"key":"155808","doi-asserted-by":"crossref","unstructured":"Puthucheary ZA, Rawal J, McPhail M, Connolly B, Ratnayake G, Chan P, et al. Acute skeletal muscle wasting in critical illness. JAMA 2013; 310: 1591\u20131600.","DOI":"10.1001\/jama.2013.278481"},{"key":"155809","doi-asserted-by":"crossref","unstructured":"Muscedere J, Waters B, Varambally A, Bagshaw SM, Boyd JG, Maslove D, et al. The impact of frailty on intensive care unit outcomes: a systematic review and meta-analysis. Intensive Care Med 2017; 43: 1105\u20131122.","DOI":"10.1007\/s00134-017-4867-0"},{"key":"155810","doi-asserted-by":"crossref","unstructured":"Myers EA, Smith DA, Allen SR, Kaplan LJ. Post-ICU syndrome: rescuing the undiagnosed. Jaapa 2016; 29: 34\u201337.","DOI":"10.1097\/01.JAA.0000481401.21841.32"},{"key":"155811","doi-asserted-by":"crossref","unstructured":"Schweickert WD, Pohlman MC, Pohlman AS, Nigos C, Pawlik AJ, Esbrook CL, et al. Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet 2009; 373: 1874\u20131882.","DOI":"10.1016\/S0140-6736(09)60658-9"},{"key":"155812","doi-asserted-by":"crossref","unstructured":"Denehy L, Skinner EH, Edbrooke L, Haines K, Warrillow S, Hawthorne G, et al. Exercise rehabilitation for patients with critical illness: a randomized controlled trial with 12 months of follow-up. Crit Care 2013; 17: R156.","DOI":"10.1186\/cc12835"},{"key":"155813","doi-asserted-by":"crossref","unstructured":"Stelfox HT, Soo A, Niven DJ, Fiest KM, Wunsch H, Rowan KM, et al. Assessment of the safety of discharging select patients directly home from the intensive care unit: a multicenter population-based cohort study. JAMA Intern Med 2018; 178: 1390\u20131399.","DOI":"10.1001\/jamainternmed.2018.3675"},{"key":"155814","doi-asserted-by":"crossref","unstructured":"Hsieh SJ, Otusanya O, Gershengorn HB, Hope AA, Dayton C, Levi D, et al. Staged implementation of awakening and breathing, coordination, delirium monitoring and management, and early mobilization bundle improves patient outcomes and reduces hospital costs. Crit Care Med 2019; 47: 885\u2013893.","DOI":"10.1097\/CCM.0000000000003765"},{"key":"155815","doi-asserted-by":"crossref","unstructured":"Liu K, Ogura T, Takahashi K, Nakamura M, Ohtake H, Fujiduka K, et al. A progressive early mobilization program is significantly associated with clinical and economic improvement: a single-center quality comparison study. Crit Care Med 2019; 47: e744\u2013e752.","DOI":"10.1097\/CCM.0000000000003850"},{"key":"155816","doi-asserted-by":"crossref","unstructured":"Henneman E, Dracup K, Ganz T, Molayeme O, Cooper CB. Using a collaborative weaning plan to decrease duration of mechanical ventilation and length of stay in the intensive care unit for patients receiving long-term ventilation. Am J Crit Care 2002; 11: 132\u2013140.","DOI":"10.4037\/ajcc2002.11.2.132"},{"key":"155817","doi-asserted-by":"crossref","unstructured":"Huang M, Chan KS, Zanni JM, Parry SM, Neto SG, Neto JA, et al. Functional Status Score for the ICU: an international clinimetric analysis of validity, responsiveness, and minimal important difference. Crit Care Med 2016; 44: e1155\u2013e1164.","DOI":"10.1097\/CCM.0000000000001949"},{"key":"155818","doi-asserted-by":"crossref","unstructured":"Tymkew H, Norris T, Arroyo C, Schallom M. The use of physical therapy ICU assessments to predict discharge home. Crit Care Med 2020; 48: 1312\u20131318.","DOI":"10.1097\/CCM.0000000000004467"},{"key":"155819","doi-asserted-by":"crossref","unstructured":"Shimogai T, Izawa KP, Kawada M, Kuriyama A. Factors affecting discharge to home of medical patients treated in an intensive care unit. Int J Environ Res Public Health 2019; 16.","DOI":"10.3390\/ijerph16224324"},{"key":"155820","doi-asserted-by":"crossref","unstructured":"Parry SM, Denehy L, Beach LJ, Berney S, Williamson HC, Granger CL. Functional outcomes in ICU \u2013 what should we be using? \u2013 an observational study. Crit Care 2015; 19: 127.","DOI":"10.1186\/s13054-015-0829-5"},{"key":"155821","doi-asserted-by":"crossref","unstructured":"Kim RY, Murphy TE, Doyle M, Pulaski C, Singh M, Tsang S, et al. Factors associated with discharge home among medical ICU Patients in an early mobilization program. Crit Care Explor 2019; 1: e0060.","DOI":"10.1097\/CCE.0000000000000060"},{"key":"155822","doi-asserted-by":"crossref","unstructured":"Zhang L, Hu W, Cai Z, Liu J, Wu J, Deng Y, et al. Early mobilization of critically ill patients in the intensive care unit: a systematic review and meta-analysis. PLoS One 2019; 14: e0223185.","DOI":"10.1371\/journal.pone.0223185"},{"key":"155823","doi-asserted-by":"crossref","unstructured":"Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, et al. A global clinical measure of fitness and frailty in elderly people. CMAJ 2005; 173: 489\u2013495.","DOI":"10.1503\/cmaj.050051"},{"key":"155824","doi-asserted-by":"crossref","unstructured":"Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med 1985; 13: 818\u2013829.","DOI":"10.1097\/00003246-198510000-00009"},{"key":"155825","doi-asserted-by":"crossref","unstructured":"Wright SE, Thomas K, Watson G, Baker C, Bryant A, Chadwick TJ, et al. Intensive versus standard physical rehabilitation therapy in the critically ill (EPICC): a multicentre, parallel-group, randomised controlled trial. Thorax 2018; 73: 213\u2013221.","DOI":"10.1136\/thoraxjnl-2016-209858"},{"key":"155826","doi-asserted-by":"crossref","unstructured":"Kleyweg RP, van der Mech\u00e9 FG, Schmitz PI. Interobserver agreement in the assessment of muscle strength and functional abilities in Guillain-Barr\u00e9 syndrome. Muscle Nerve 1991; 14: 1103\u20131109.","DOI":"10.1002\/mus.880141111"},{"key":"155827","doi-asserted-by":"crossref","unstructured":"Vanpee G, Hermans G, Segers J, Gosselink R. Assessment of limb muscle strength in critically ill patients: a systematic review. Crit Care Med 2014; 42: 701\u2013711.","DOI":"10.1097\/CCM.0000000000000030"},{"key":"155828","doi-asserted-by":"crossref","unstructured":"Frenkel WJ, Jongerius EJ, Mandjes-van Uitert MJ, van Munster BC, de Rooij SE. Validation of the Charlson Comorbidity Index in acutely hospitalized elderly adults: a prospective cohort study. J Am Geriatr Soc 2014; 62: 342\u2013346.","DOI":"10.1111\/jgs.12635"},{"key":"155829","doi-asserted-by":"crossref","unstructured":"Bergeron N, Dubois MJ, Dumont M, Dial S, Skrobik Y. Intensive Care Delirium Screening Checklist: evaluation of a new screening tool. Intensive Care Med 2001; 27: 859\u2013864.","DOI":"10.1007\/s001340100909"},{"key":"155830","doi-asserted-by":"crossref","unstructured":"Harada N, Gotoh M, Ishitani E, Kakuma T, Yano Y, Tatara D, et al. Combination of risk factors affecting retear after arthroscopic rotator cuff repair: a decision tree analysis. J Shoulder Elbow Surg 2021; 30: 9\u201315.","DOI":"10.1016\/j.jse.2020.05.006"},{"key":"155831","doi-asserted-by":"crossref","unstructured":"Chowdhury MZI, Turin TC. Variable selection strategies and its importance in clinical prediction modelling. Fam Med Community Health 2020; 8: e000262.","DOI":"10.1136\/fmch-2019-000262"},{"key":"155832","doi-asserted-by":"crossref","unstructured":"Gadre SK, Duggal A, Mireles-Cabodevila E, Krishnan S, Wang XF, Zell K, et al. Acute respiratory failure requiring mechanical ventilation in severe chronic obstructive pulmonary disease (COPD). Medicine (Baltimore) 2018; 97: e0487.","DOI":"10.1097\/MD.0000000000010487"},{"key":"155833","doi-asserted-by":"crossref","unstructured":"Trivedi V, Bleeker H, Kantor N, Visintini S, McIsaac DI, McDonald B. Survival, quality of life, and functional status following prolonged ICU stay in cardiac surgical patients: a systematic review. Crit Care Med 2019; 47: e52\u2013e63.","DOI":"10.1097\/CCM.0000000000003504"},{"key":"155834","doi-asserted-by":"crossref","unstructured":"Thrush A, Rozek M, Dekerlegand JL. The clinical utility of the functional status score for the intensive care unit (FSS-ICU) at a long-term acute care hospital: a prospective cohort study. Phys Ther 2012; 92: 1536\u20131545.","DOI":"10.2522\/ptj.20110412"},{"key":"155835","doi-asserted-by":"crossref","unstructured":"Martin GS, Mannino DM, Moss M. The effect of age on the development and outcome of adult sepsis. Crit Care Med 2006; 34: 15\u201321.","DOI":"10.1097\/01.CCM.0000194535.82812.BA"},{"key":"155836","doi-asserted-by":"crossref","unstructured":"Davydow DS, Hough CL, Langa KM, Iwashyna TJ. Presepsis depressive symptoms are associated with incident cognitive impairment in survivors of severe sepsis: a prospective cohort study of older Americans. J Am Geriatr Soc 2012; 60: 2290\u20132296.","DOI":"10.1111\/jgs.12001"},{"key":"155837","doi-asserted-by":"crossref","unstructured":"Chelluri L, Im KA, Belle SH, Schulz R, Rotondi AJ, Donahoe MP, et al. Long-term mortality and quality of life after prolonged mechanical ventilation. Crit Care Med 2004; 32: 61\u201369.","DOI":"10.1097\/01.CCM.0000098029.65347.F9"},{"key":"155838","doi-asserted-by":"crossref","unstructured":"Goldhill DR, Sumner A. APACHE II, data accuracy and outcome prediction. Anaesthesia 1998; 53: 937\u2013943.","DOI":"10.1046\/j.1365-2044.1998.00534.x"},{"key":"155839","doi-asserted-by":"crossref","unstructured":"Hiser S, Toonstra A, Friedman LA, Colantuoni E, Connolly B, Needham DM. Interrater rReliability of the Functional Status Score for the intensive care unit. J Acute Care Phys Ther 2018; 9: 186\u2013192.","DOI":"10.1097\/JAT.0000000000000086"},{"key":"155840","doi-asserted-by":"crossref","unstructured":"Takekawa D, Endo H, Hashiba E, Hirota K. Predict models for prolonged ICU stay using APACHE II, APACHE III and SAPS II scores: a Japanese multicenter retrospective cohort study. PLoS One 2022; 17: e0269737.","DOI":"10.1371\/journal.pone.0269737"},{"key":"155841","doi-asserted-by":"crossref","unstructured":"Atramont A, Lindecker-Cournil V, Rudant J, Tajahmady A, Drewniak N, Fouard A, et al. Association of age with short-term and long-term mortality among patients discharged from intensive care units in France. JAMA Netw Open 2019; 2: e193215.","DOI":"10.1001\/jamanetworkopen.2019.3215"},{"key":"155842","doi-asserted-by":"crossref","unstructured":"Martin CM, Lam M, Allen B, Richard L, Lau V, Ball IM, et al. Determinants of direct discharge home from critical care units: a population-based cohort analysis. Crit Care Med 2020; 48: 475\u2013483.","DOI":"10.1097\/CCM.0000000000004178"}],"container-title":["Journal of Rehabilitation Medicine"],"original-title":[],"link":[{"URL":"https:\/\/medicaljournalssweden.se\/jrm\/article\/download\/44237\/53989","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicaljournalssweden.se\/jrm\/article\/download\/44237\/53989","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:52:34Z","timestamp":1779263554000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicaljournalssweden.se\/jrm\/article\/view\/44237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,20]]},"references-count":36,"URL":"https:\/\/doi.org\/10.2340\/jrm.v58.44237","relation":{},"ISSN":["1651-2081"],"issn-type":[{"value":"1651-2081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,20]]}}}