{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:22:53Z","timestamp":1777983773396,"version":"3.51.4"},"reference-count":46,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JRM"],"abstract":"<jats:p>Objective: To determine physical activity levels and their associated factors post-dysvascular major lower limb amputation.\nDesign: Multicentre longitudinal observational study.\nSubjects: Eighty-one adults with dysvascular major lower limb amputation.\nMethod: Physical activity was assessed via questionnaire (adapted-SQUASH: total min, moderate\/vigorous min, MET-min\/week), self-reported adherence to Dutch physical activity guidelines, and accelerometer (Activ8: min, bouts, fragmentation) at &lt;\u200912 days, 5 weeks, 6 months, and 9 months post-amputation. Associated factors were assessed using mixed model analysis.\nResults: Median [interquartile range] questionnaire-assessed activity increased: 240 [90;600], 525 [245;880], 678 [334;1176], and 885 [525;1733] min\/week (p\u2009=\u20090.004). Dutch guideline adherence was 16%, 55%, 47%, and 27%, respectively. Accelerometer-derived activity was 5 [5;9], 26 [13;50], 50 [33;64], and 54 [44;67] min\/day. Number of active bouts ranged from 0.0 [0.0;0.0] to 2.0 [1.0;3.0] per day, with fragmentation between 0.0 [0.0;0.0] and 0.4 [0.4;0.5]. Questionnaire-assessed physical activity was negatively associated with age (\u03b2\u2009=\u2009\u201316 min\/week, p\u2009=\u20090.009) and undernutrition (\u03b2\u2009=\u2009\u2013270 min\/week, p\u2009=\u20090.013), and positively with grip strength (\u03b2\u2009=\u200914 min\/week, p\u2009=\u20090.014).\nConclusion: Physical activity levels increase but remain low post-lower limb amputation. Age, undernutrition, and grip strength are associated with physical activity. These findings underscore the need for targeted physical activity interventions for individuals post-amputation, to optimize health and clinical outcomes.<\/jats:p>","DOI":"10.2340\/jrm.v58.44666","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T11:44:53Z","timestamp":1777981493000},"page":"jrm44666","source":"Crossref","is-referenced-by-count":0,"title":["Physical activity levels are low in the days, weeks, and months following dysvascular major lower limb amputation"],"prefix":"10.2340","volume":"58","author":[{"given":"Aniek K.","family":"Kolen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonie A.","family":"Krops","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harri\u00ebt","family":"Jager-Wittenaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herwin","family":"Horemans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes B.J.","family":"Bussmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martijn L.","family":"Dijkstra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.A.","family":"Keller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Oskam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bastiaan","family":"Vierhout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Paul P.M.","family":"De Vries","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurens","family":"Van Walraven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim P.","family":"Krijnen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan H.B.","family":"Geertzen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rienk","family":"Dekker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1183","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"154378","doi-asserted-by":"crossref","unstructured":"Warburton DE, Bredin SS. 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