{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:10:36Z","timestamp":1770880236027,"version":"3.50.1"},"reference-count":40,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JRM"],"abstract":"<jats:p>Objective: To predict treatment response of a family intervention and investigate its cost-effectiveness from a healthcare payer perspective.\nDesign: Explorative predictor analyses and trial-based economic evaluation.\nSubjects\/Patients: Participants (n=157) were enrolled 4 months to 2 years after discharge from a specialized neurorehabilitation unit.\nMethods: Injury type, time since injury, delivery format, and relationship (individual with injury vs family member) were explored as predictors of effect using linear mixed-effect regression. Cost-effectiveness was analysed from a healthcare payer perspective, with incremental cost based on delivery. Incremental health effect was reported for measures on mental health and anxiety and depression symptoms. \nResults: The 4 predictors had negligible to small effects on the treatment response. Incremental cost for the family intervention was estimated at \u20ac798.16 (CI: \u20ac700.9; \u20ac895.5). Incremental health effect was estimated at 5.64 (CI: 2.71, 8.56) points on the Mental Component Summary at 2 months\u2019 follow-up. At a willingness-to-pay threshold of \u20ac300, the probability of the intervention being cost-effective was 99.8% for the Mental Component Summary.\nConclusion: The predictors showed no or little effect on the treatment response, and the cost-effectiveness analysis showed the probabilities of the intervention being cost-effective from a health payer perspective.<\/jats:p>","DOI":"10.2340\/jrm.v58.44691","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T06:28:06Z","timestamp":1770877686000},"page":"jrm44691","source":"Crossref","is-referenced-by-count":0,"title":["Predicting effect and evaluating cost-effectiveness of a family intervention after acquired brain or spinal cord injury: a randomized controlled trial"],"prefix":"10.2340","volume":"58","author":[{"given":"Karoline Yde","family":"Andersen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederik Have","family":"Dornonville de la Cour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia Moth","family":"Wolffbrandt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fin","family":"Biering-S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Arango-Lasprilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pernille Langer","family":"Soendergaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Norup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1183","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"141490","unstructured":"Norup A. 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