{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T02:49:29Z","timestamp":1769309369640,"version":"3.49.0"},"reference-count":30,"publisher":"MJS Publishing, Medical Journals Sweden AB","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["SJU"],"abstract":"<jats:p>Objective: A positive surgical margin (PSM) after radical prostatectomy (RP) is considered an adverse surgical feature, but the clinical implications have been debated. Further motive to aim for negative margins (NSM) may be patient anxiety due to PSM, but studies on psychological consequences are lacking. We explored associations between psychological factors and PSM on a consecutive group of men after RP.\nMaterial and methods: Men with suspected prostate cancer were invited to a study on psychological factors. Patient reported outcome measurement questionnaires were collected before diagnosis, and at 6, 12 and 24 months from those who underwent RP. Multivariable mixed models and post hoc pairwise comparisons were used to explore associations between PSM and psychological outcomes.\nResults: In total, 387 men had RP and 94 (24%) had PSM. General psychological outcomes were not associated with margin status. At 12 months, men with PSM considered their personal risk of recurrence 6% (30% vs. 24%) points higher and had clinical fear of recurrence (FoR) 14% (47% vs. 33%) more often than men with NSM. In adjusted and stratified analyses, men with pathological (p-)T2-stage and NSM had less FoR than the rest of the sample. In pT3-disease, PSM had no additional impact on FoR. A limitation was the small size of the pT2 group with PSM and the lack of information on how patients were informed.\nConclusions: After RP, PSM was associated with higher FoR, particularly in men with pT2-cancer. Improved counselling and further research into causes and mitigation of FoR, is warranted.<\/jats:p>","DOI":"10.2340\/sju.v61.45306","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T18:48:52Z","timestamp":1768934932000},"page":"15-21","source":"Crossref","is-referenced-by-count":0,"title":["In pathological T2-prostate cancers a positive surgical margin is associated with adverse psychological outcomes"],"prefix":"10.2340","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8190-9296","authenticated-orcid":false,"given":"Rasmus","family":"Nilsson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tor \u00c5ge","family":"Myklebust","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"N\u00e6ss-Andresen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomm","family":"Bernklev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hege","family":"Kersten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik \u00adSkaaheim","family":"Haug","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1183","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"139223","doi-asserted-by":"crossref","unstructured":"Novara G, Ficarra V, Mocellin S, et al. Systematic review and meta-analysis of studies reporting oncologic outcome after robot-assisted radical prostatectomy. Eur Urol. 2012;62(3):382\u2013404. https:\/\/doi.org\/10.1016\/j.eururo.2012.05.047","DOI":"10.1016\/j.eururo.2012.05.047"},{"key":"139224","doi-asserted-by":"crossref","unstructured":"Yossepowitch O, Briganti A, Eastham JA, et al. Positive surgical margins after radical prostatectomy: a systematic review and contempo-rary update. Eur Urol. 2014;65(2):303\u2013313. https:\/\/doi.org\/10.1016\/j.eururo.2013.07.039","DOI":"10.1016\/j.eururo.2013.07.039"},{"key":"139225","doi-asserted-by":"crossref","unstructured":"Mauermann J, Fradet V, Lacombe L, et al. The impact of solitary and multiple positive surgical margins on hard clinical end points in 1712 adjuvant treatment-naive pT2-4 N0 radical prostatectomy patients. 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Evaluation of oncological outcomes and data quality in studies assessing nerve-sparing versus non-nerve-sparing radical prostatectomy in nonmetastatic prostate cancer: a systematic review. Eur Urol Focus. 2022;8(3):690\u2013700. https:\/\/doi.org\/10.1016\/j.euf.2021.05.009","DOI":"10.1016\/j.euf.2021.05.009"},{"key":"139231","doi-asserted-by":"crossref","unstructured":"Hong YM, Hu JC, Paciorek AT, et al. Impact of radical prostatectomy positive surgical margins on fear of cancer recurrence: results from CaPSURE. Urol Oncol. 2010;28(3):268\u2013273. https:\/\/doi.org\/10.1016\/j.urolonc.2008.07.004","DOI":"10.1016\/j.urolonc.2008.07.004"},{"key":"139232","doi-asserted-by":"crossref","unstructured":"Nilsson R, N\u00e6ss-Andresen TF, Myklebust T, et al. Fear of recurrence in prostate cancer patients: a cross-sectional study after radical pros-tatectomy or active surveillance. 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