{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T01:45:22Z","timestamp":1789868722321,"version":"4.0.1"},"reference-count":13,"publisher":"Operative Dentistry","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n        <jats:p>Studies show that human permanent teeth with carious pulpal exposures can result in a high clinical success rate when treated with pulpotomy and direct pulp capping with mineral trioxide aggregate (MTA pulpotomy). In this case report, a 19-year-old female patient with a second premolar with irreversible pulpitis and symptomatic apical periodontitis was treated with MTA pulpotomy. Follow-up electric pulp tests showed viability of the tooth at three and 10 months. Ten months after the initial treatment, the tooth was extracted for orthodontic reasons and processed for histological examination. Microscopically, the pulpal wound treated with MTA was free from inflammation and covered with a thin layer of reparative dentin. The authors conclude that, when caries and bacterial contamination can be removed from the dentin-pulp complex, the inflamed but vital pulp of a permanent tooth may have a chance to return to a healthy, functional status after MTA pulpotomy.<\/jats:p>","DOI":"10.2341\/09-307-s","type":"journal-article","created":{"date-parts":[[2010,5,14]],"date-time":"2010-05-14T17:05:33Z","timestamp":1273856733000},"page":"370-374","source":"Crossref","is-referenced-by-count":36,"title":["Histology of Irreversible Pulpitis Premolars Treated with Mineral Trioxide Aggregate Pulpotomy"],"prefix":"10.2341","volume":"35","author":[{"given":"L-H.","family":"Chueh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C-P.","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1188","reference":[{"issue":"2","key":"i1559-2863-35-3-370-b1","series-title":"European Archives of Paediatric Dentistry","first-page":"58","article-title":"Mineral trioxide aggregate as a pulpotomy medicament: An evidence-based assessment.","volume":"9","year":"2008","unstructured":"Ng, F. K. and L. B.Messer. 2008. Mineral trioxide aggregate as a pulpotomy medicament: An evidence-based assessment.European Archives of Paediatric Dentistry92:58\u201373."},{"issue":"6","key":"i1559-2863-35-3-370-b2","series-title":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics","first-page":"e40","article-title":"Evaluation of the formocresol versus mineral trioxide aggregate primary molar pulpotomy: A meta-analysis.","volume":"102","year":"2006","unstructured":"Peng, L., L.Ye, H.Tan, and X.Zhou. 2006. Evaluation of the formocresol versus mineral trioxide aggregate primary molar pulpotomy: A meta-analysis.Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics1026:e40\u2013e44."},{"issue":"3","key":"i1559-2863-35-3-370-b3","series-title":"Pediatric Dentistry","first-page":"220","article-title":"Vital pulp therapy with new materials: New directions and treatment perspectives\u2014permanent teeth.","volume":"30","year":"2008","unstructured":"Witherspoon, D. E.\n          \n          2008. Vital pulp therapy with new materials: New directions and treatment perspectives\u2014permanent teeth.Pediatric Dentistry303:220\u2013224."},{"issue":"2","key":"i1559-2863-35-3-370-b4","series-title":"International Endodontic Journal","first-page":"128","article-title":"Histological, ultrastructural and quantitative investigations on the response of healthy human pulps to experimental capping with mineral trioxide aggregate: A randomized controlled trial.","volume":"41","year":"2008","unstructured":"Nair, P. N., H. F.Duncan, T. R.Pitt Ford, and H. U.Luder. 2008. Histological, ultrastructural and quantitative investigations on the response of healthy human pulps to experimental capping with mineral trioxide aggregate: A randomized controlled trial.International Endodontic Journal412:128\u2013150."},{"issue":"3","key":"i1559-2863-35-3-370-b5","series-title":"Journal of Clinical Pediatric Dentistry","first-page":"203","article-title":"Human pulpal response to mineral trioxide aggregate (MTA): A histologic study.","volume":"30","year":"2006","unstructured":"Chacko, V. and S.Kurikose. 2006. Human pulpal response to mineral trioxide aggregate (MTA): A histologic study.Journal of Clinical Pediatric Dentistry303:203\u2013209."},{"issue":"2","key":"i1559-2863-35-3-370-b6","series-title":"European Archives of Paediatric Dentistry","first-page":"99","article-title":"Calcium hydroxide vs mineral trioxide aggregates for partial pulpotomy of permanent molars with deep caries.","volume":"8","year":"2007","unstructured":"Qudeimat, M. A., K. M.Barrieshi-Nusair, and A. I.Owais. 2007. Calcium hydroxide vs mineral trioxide aggregates for partial pulpotomy of permanent molars with deep caries.European Archives of Paediatric Dentistry82:99\u2013104."},{"issue":"8","key":"i1559-2863-35-3-370-b7","series-title":"Journal of Endodontics","first-page":"731","article-title":"A prospective clinical study of mineral trioxide aggregate for partial pulpotomy in cariously exposed permanent teeth.","volume":"32","year":"2006","unstructured":"Barrieshi-Nusair, K. M. and M. A.Qudeimat. 2006. A prospective clinical study of mineral trioxide aggregate for partial pulpotomy in cariously exposed permanent teeth.Journal of Endodontics328:731\u2013735."},{"issue":"5","key":"i1559-2863-35-3-370-b8","series-title":"Journal of the American Dental Association","first-page":"610","article-title":"Mineral trioxide aggregate pulpotomies: A case series outcomes assessment.","volume":"137","year":"2006","unstructured":"Witherspoon, D. E., J. C.Small, and G. Z.Harris. 2006. Mineral trioxide aggregate pulpotomies: A case series outcomes assessment.Journal of the American Dental Association1375:610\u2013618."},{"issue":"2","key":"i1559-2863-35-3-370-b9","series-title":"Dental Materials","first-page":"149","article-title":"Mineral trioxide aggregate material use in endodontic treatment: A review of the literature.","volume":"24","year":"2008","unstructured":"Roberts, H. W., J. M.Toth, D. W.Berzins, and D. G.Charlton. 2008. Mineral trioxide aggregate material use in endodontic treatment: A review of the literature.Dental Materials242:149\u2013164."},{"issue":"2","key":"i1559-2863-35-3-370-b10","series-title":"Journal of Endodontics","first-page":"160","article-title":"Regenerative endodontic treatment for necrotic immature permanent teeth.","volume":"35","year":"2009","unstructured":"Chueh, L. H., Y. C.Ho, T. C.Kuo, W. H.Lai, Y. H. M.Chen, and C. P.Chiang. 2009. Regenerative endodontic treatment for necrotic immature permanent teeth.Journal of Endodontics352:160\u2013164."},{"issue":"7","key":"i1559-2863-35-3-370-b11","series-title":"Journal of Endodontics","first-page":"S51","article-title":"Regeneration potential of the young permanent tooth: What does the future hold.","volume":"34","year":"2008","unstructured":"Hargreaves, K. M., T.Geisler, M.Henry, and Y.Wang. 2008. Regeneration potential of the young permanent tooth: What does the future hold.Journal of Endodontics347:S51\u2013S56."},{"issue":"7","key":"i1559-2863-35-3-370-b12","series-title":"Journal of Endodontics","first-page":"876","article-title":"Biologically based treatment of immature permanent teeth with pulpal necrosis: A case series.","volume":"34","year":"2008","unstructured":"Jung, I. Y., S. J.Lee, and K. M.Hargreaves. 2008. Biologically based treatment of immature permanent teeth with pulpal necrosis: A case series.Journal of Endodontics347:876\u2013887."},{"issue":"8","key":"i1559-2863-35-3-370-b13","series-title":"Oral Surgery Oral Medicine Oral Pathology","first-page":"846","article-title":"The dynamics of pulp inflammation: Correlations between diagnostic data and actual histologic findings in the pulp.","volume":"16","year":"1963","unstructured":"Seltzer, S., I. B.Bender, and M.Ziontz. 1963. The dynamics of pulp inflammation: Correlations between diagnostic data and actual histologic findings in the pulp.Oral Surgery Oral Medicine Oral Pathology168:846\u2013871."}],"container-title":["Operative Dentistry"],"original-title":[],"link":[{"URL":"https:\/\/operative-dentistry.kglmeridian.com\/view\/journals\/odnt\/35\/3\/article-p370.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/operative-dentistry\/article-pdf\/35\/3\/370\/2152432\/09-307-s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/operative-dentistry.kglmeridian.com\/downloadpdf\/journals\/odnt\/35\/3\/article-p370.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/operative-dentistry.kglmeridian.com\/downloadpdf\/journals\/odnt\/35\/3\/article-p370.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:42:33Z","timestamp":1758933753000},"score":1,"resource":{"primary":{"URL":"https:\/\/operative-dentistry.kglmeridian.com\/view\/journals\/odnt\/35\/3\/article-p370.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":13,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.2341\/09-307-s","relation":{},"ISSN":["1559-2863","0361-7734"],"issn-type":[{"value":"1559-2863","type":"electronic"},{"value":"0361-7734","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}