{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:41:00Z","timestamp":1788514860381,"version":"build-2803163510"},"reference-count":68,"publisher":"Operative Dentistry","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"abstract":"SUMMARY<\/jats:title>\n \n Objectives:<\/jats:bold> The tooth\/restoration interface may act as a pathway for hydrogen peroxide (H2<\/jats:sub>O2<\/jats:sub>) diffusion into the pulp chamber. Therefore, the influence of resin-modified glass ionomer cement (RMGIC) and resin composite simulated restorations on the cytotoxicity of an in-office bleaching gel was assessed in vitro<\/jats:italic>.<\/jats:p>\n \n Materials and Methods:<\/jats:bold> Cavities in enamel\/dentin discs restored with RMGIC Vitremer (3M ESPE) or Single Bond\/Filtek Z350 (3M ESPE) resin composite (RC) were subjected or not subjected to hydrolytic degradation (HD). A 35%-H2<\/jats:sub>O2<\/jats:sub> bleaching gel was applied to simulated restored and nonrestored enamel surfaces, and culture medium in contact with the dentin substrate (extract) was collected and applied to MDPC-23 cells. Nonrestored discs subjected or not subjected to bleaching were used as positive and negative controls, respectively. Cell viability, oxidative stress, interleukin (IL)-1\u03b2 expression, alkaline phosphatase (ALP) activity, and mineralized nodule deposition were evaluated. The H2<\/jats:sub>O2<\/jats:sub> in the extracts was quantified. Data were subjected to statistical analysis.<\/jats:p>\n \n Results:<\/jats:bold> Higher oxidative stress associated with reduced cell viability, ALP activity, and mineralized nodule deposition was observed for all bleached groups compared with the negative control group. The RMGIC\/HD group, which presented the highest H2<\/jats:sub>O2<\/jats:sub> diffusion, had the lowest values of cell viability, ALP activity, and mineralized nodule deposition, as well as significantly increased IL-1\u03b2 expression.<\/jats:p>\n \n Conclusions:<\/jats:bold> Dental cavities restored with the RMGIC subjected to hydrolytic degradation allowed for more intense diffusion of H2<\/jats:sub>O2<\/jats:sub> into the pulp chamber, intensifying the toxicity of a 35%-H2<\/jats:sub>O2<\/jats:sub> bleaching gel to pulp cells.<\/jats:p>","DOI":"10.2341\/14-325-l","type":"journal-article","created":{"date-parts":[[2015,12,12]],"date-time":"2015-12-12T21:37:39Z","timestamp":1449956259000},"page":"293-304","source":"Crossref","is-referenced-by-count":8,"title":["Influence of Restoration Type on the Cytotoxicity of a 35% Hydrogen Peroxide Bleaching Gel"],"prefix":"10.2341","volume":"41","author":[{"given":"DG","family":"Soares","sequence":"first","affiliation":[{"name":"Diana Gabriela Soares DDS, Ms, PhD, Department of Physiology and Pathology, Araraquara School of Dentistry, Univ Estadual Paulista \u2013 UNESP, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Marcomini","sequence":"additional","affiliation":[{"name":"Nat\u00e1lia Marcomini undergraduate student, Department of Physiology and Pathology, Araraquara School of Dentistry, Univ Estadual Paulista \u2013 UNESP, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FG","family":"Basso","sequence":"additional","affiliation":[{"name":"Fernanda Gon\u00e7alves Basso DDS, Ms, PhD, Department of Physiology and Pathology, Araraquara School of Dentistry, Univ Estadual Paulista \u2013 UNESP, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TN","family":"Pansani","sequence":"additional","affiliation":[{"name":"Taisa N Pansani DDS, Ms, Department of Dental Materials and Prosthodontics, Araraquara School of Dentistry, Univ Estadual Paulista \u2013 UNESP, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Hebling","sequence":"additional","affiliation":[{"name":"Josimeri Hebling DDS, Ms, PhD, associate professor, Department of Orthodontics and Pediatric Dentistry, Araraquara School of Dentistry, Univ Estadual Paulista \u2013 UNESP, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CA","family":"de Souza Costa","sequence":"additional","affiliation":[{"name":"Carlos A de Souza Costa DDS, Ms, PhD, professor, Department of Physiology and Pathology, Araraquara School of Dentistry, Univ Estadual Paulista \u2013 UNESP, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1188","reference":[{"issue":"1","key":"i1559-2863-41-3-293-b01","series-title":"Operative Dentistry","first-page":"3","article-title":"Clinical performance of vital bleaching 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