{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:02:27Z","timestamp":1759017747960,"version":"3.44.0"},"reference-count":41,"publisher":"Operative Dentistry","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"abstract":"SUMMARY<\/jats:title>\n \n Objective<\/jats:title>\n To compare the ability of two calcium-releasing restorative materials to inhibit root dentin demineralization in an artificial caries model.<\/jats:p>\n <\/jats:sec>\n \n Methods and Materials<\/jats:title>\n Preparations were made at the cementum\u2013enamel junction of extracted human molars (40, n=10\/material) and restored with two calcium-releasing materials (Experimental composite, Pulpdent Corporation and Cention N, Ivoclar Vivadent), a resin composite (Filtek Supreme Ultra, 3M Oral Care), and a resin-modified glass ionomer (RMGI) (Fuji II LC, GC). All materials (other than the RMGI) were used with an adhesive (Scotchbond Universal Adhesive, 3M Oral Care) in the self-etch mode, which was light cured for 10 seconds. All restorative materials were light cured in 2-mm increments for 20 seconds and then finished with a polishing disc. Teeth were incubated (37\u00b0C) for 24 hours in water. An acid-resistant varnish was painted onto the teeth around the restoration, leaving a 2-mm border of uncovered tooth. A demineralization solution composed of 0.1 M lactic acid, 3 mM Ca3<\/jats:sub>(PO4<\/jats:sub>)2<\/jats:sub>, 0.1% thymol, and NaOH (to adjust pH=4.5), and a remineralization solution composed of 1.5 mM Ca, 0.9 mM P, and 20 mM Tris(hydroxymethyl)\u2013aminomethane (pH=7.0) were prepared. Specimens were placed in the demineralization solution for 4 hours, followed by the remineralization solution for 20 hours and cycled daily for 30 days. The specimens were embedded, sectioned into 100-\u03bcm sections, and the interface between the restorative material and root dentin was viewed with polarized light microscopy. A line was drawn parallel with the zone of demineralization for each tooth. The area of \u201cinhibition\u201d (defined as the area external to the line) or \u201cwall lesion\u201d (defined as the area internal to the line) was measured with image evaluation software. Areas of inhibition were measured as positive values, and areas of wall lesions were measured as negative areas.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A one-way analysis of variance (ANOVA) found significant differences between materials for \u201cinhibition\/wall lesion\u201d areas in root dentin (p<\/jats:italic><0.001). Tukey post hoc analysis ranked materials (\u03bcm2<\/jats:sup>, mean \u00b1SD): Fuji II LC (5412\u00b12754) > Cention N (2768\u00b11576) and experimental composite (1484\u00b11585) > Filtek Supreme Ultra (\u22121119\u00b11029).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The experimental composite and Cention N materials (used with an adhesive) showed net areas of inhibition greater than a reference resin composite, albeit at a lower level than a reference RMGI material (used with no adhesive).<\/jats:p>\n <\/jats:sec>","DOI":"10.2341\/20-074-l","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T16:02:01Z","timestamp":1651680121000},"page":"680-689","source":"Crossref","is-referenced-by-count":1,"title":["Demineralization Inhibition by Two Calcium-releasing Restorative Materials"],"prefix":"10.2341","volume":"46","author":[{"given":"CT","family":"Huang","sequence":"first","affiliation":[{"name":"Chan-Te Huang, DMD, MS, Clinical and Community Sciences, Division of Biomaterials, University of Alabama at Birmingham School of Dentistry, Birmingham, Alabama, and Department of Dentistry, Chang Gung Memorial Hospital at Keel-ung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JO","family":"Burgess","sequence":"additional","affiliation":[{"name":"John O Burgess, DDS, MS, Clinical and Community Sciences, Division of Biomaterials, University of Alabama at Birmingham School of Dentistry, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Robles","sequence":"additional","affiliation":[{"name":"Augusto Robles, DMD, MS, Restorative Dentistry, University of Alabama at Birmingham School of Dentistry, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NC","family":"Lawson","sequence":"additional","affiliation":[{"name":"*Nathaniel C Lawson, DMD, PhD, Clinical and Community Sciences, Division of Biomaterials, University of Alabama at Birmingham School of Dentistry, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1188","reference":[{"issue":"4","key":"i1559-2863-46-6-680-b1","series-title":"Stomatology Edu Journal","first-page":"202","article-title":"The value of consensus conferences: Peer review by 50 key opinion leaders","volume":"5","year":"2018","unstructured":"Price\n RB\n &\n\t\t\t\t\t\tRouletJF (\n\t\t\t\t\t2018)\n\t\t\t\t\tThe value of consensus conferences: Peer review by 50 key opinion leadersStomatology Edu Journal5(\n\t\t\t\t\t4)\n\t\t\t\t\t202\u2013\n\t\t\t\t\t204."},{"issue":"2","key":"i1559-2863-46-6-680-b2","series-title":"International Journal of Oral Science","first-page":"15","article-title":"Dental remineralization via poly(amido amine) and restorative materials containing calcium phosphate nano-particles","volume":"11","year":"2019","unstructured":"Liang\n K,\n \n \n Wang\n S,\n \n \n Tao\n S,\n \n \n Xiao\n S,\n \n \n Zhou\n H,\n \n \n Wang\n P,\n \n \n Cheng\n L,\n \n \n Zhou\n X,\n \n \n Weir\n MD,\n \n \n Oates\n TW,\n \n \n Li\n J,\n &\n\t\t\t\t\t\tXuHHK (\n\t\t\t\t\t2019)\n\t\t\t\t\tDental remineralization via poly(amido amine) and restorative materials containing calcium phosphate nano-particlesInternational Journal of Oral Science11(\n\t\t\t\t\t2)\n\t\t\t\t\t15. https:\/\/dx.doi.org\/10.1038\/s41368-019-0048-z"},{"issue":"2","key":"i1559-2863-46-6-680-b3","series-title":"Dental Materials","first-page":"88","article-title":"Fluoride release profiles of restorative glass ionomer formulations","volume":"12","year":"1996","unstructured":"De Moor\n RJ,\n \n \n Verbeeck\n RM,\n &\n\t\t\t\t\t\tDe MaeyerEA (\n\t\t\t\t\t1996)\n\t\t\t\t\tFluoride release profiles of restorative glass ionomer formulationsDental Materials12(\n\t\t\t\t\t2)\n\t\t\t\t\t88\u2013\n\t\t\t\t\t95. https:\/\/dx.doi.org\/10.1016\/S0109-5641(96)80074-1"},{"issue":"1","key":"i1559-2863-46-6-680-b4","series-title":"Journal of Oral Rehabilitation","first-page":"26","article-title":"Fluoride release from glass-ionomer cements, compomers and resin composites","volume":"28","year":"2001","unstructured":"Vermeersch\n G,\n \n \n Leloup\n G,\n &\n\t\t\t\t\t\tVrevenJ (\n\t\t\t\t\t2001)\n\t\t\t\t\tFluoride release from glass-ionomer cements, compomers and resin compositesJournal of Oral Rehabilitation28(\n\t\t\t\t\t1)\n\t\t\t\t\t26\u2013\n\t\t\t\t\t32. https:\/\/dx.doi.org\/10.1046\/j.1365-2842.2001.00635.x"},{"key":"i1559-2863-46-6-680-b5","series-title":"Journal of Oral Rehabilitation","first-page":"26","article-title":"Fluoride release from glass-ionomer cements, compomers and resin composites","volume":"28","year":"2001","unstructured":"Vermeersch\n G,\n \n \n Leloup\n G,\n &\n\t\t\t\t\t\tVrevenJ (\n\t\t\t\t\t2001)\n\t\t\t\t\tFluoride release from glass-ionomer cements, compomers and resin compositesJournal of Oral Rehabilitation2826\u2013\n\t\t\t\t\t32."},{"issue":"2","key":"i1559-2863-46-6-680-b6","series-title":"Acta Odontologica Scandinavica","first-page":"93","article-title":"Long-term fluoride release from a glass ionomer cement, a compomer, and from experimental resin composites","volume":"60","year":"2002","unstructured":"Asmussen\n E\n &\n\t\t\t\t\t\tPeutzfeldtA (\n\t\t\t\t\t2002)\n\t\t\t\t\tLong-term fluoride release from a glass ionomer cement, a compomer, and from experimental resin compositesActa Odontologica Scandinavica60(\n\t\t\t\t\t2)\n\t\t\t\t\t93\u2013\n\t\t\t\t\t97. https:\/\/dx.doi.org\/10.1080\/000163502753509482"},{"issue":"2","key":"i1559-2863-46-6-680-b7","series-title":"Journal of Prosthetic Dentistry","first-page":"172","article-title":"Fluoride release of glass ionomer-based luting cements in vitro","volume":"82","year":"1999","unstructured":"Robertello\n FJ,\n \n \n Coffey\n JP,\n \n \n Lynde\n TA,\n &\n\t\t\t\t\t\tKingP (\n\t\t\t\t\t1999)\n\t\t\t\t\tFluoride release of glass ionomer-based luting cements in vitroJournal of Prosthetic Dentistry82(\n\t\t\t\t\t2)\n\t\t\t\t\t172\u2013\n\t\t\t\t\t176. https:\/\/dx.doi.org\/10.1016\/s0022-3913(99)70152-6"},{"issue":"3","key":"i1559-2863-46-6-680-b8","series-title":"Operative Dentistry","first-page":"259","article-title":"Short-term fluoride release from various aesthetic restorative materials","volume":"27","year":"2002","unstructured":"Yap\n AU,\n \n \n Tham\n SY,\n \n \n Zhu\n LY,\n &\n\t\t\t\t\t\tLeeHK (\n\t\t\t\t\t2002)\n\t\t\t\t\tShort-term fluoride release from various aesthetic restorative materialsOperative Dentistry27(\n\t\t\t\t\t3)\n\t\t\t\t\t259\u2013\n\t\t\t\t\t265."},{"issue":"8","key":"i1559-2863-46-6-680-b9","series-title":"Journal of Oral Rehabilitation","first-page":"791","article-title":"Fluoride release and uptake characteristics of aesthetic restorative materials","volume":"29","year":"2002","unstructured":"Attar\n N\n &\n\t\t\t\t\t\tOnenA (\n\t\t\t\t\t2002)\n\t\t\t\t\tFluoride release and uptake characteristics of aesthetic restorative materialsJournal of Oral Rehabilitation29(\n\t\t\t\t\t8)\n\t\t\t\t\t791\u2013\n\t\t\t\t\t798, https:\/\/dx.doi.org\/10.1046\/j.1365-2842.2002.00902.x"},{"issue":"5","key":"i1559-2863-46-6-680-b10","series-title":"Journal of Oral Rehabilitation","first-page":"388","article-title":"Fluoride release\/uptake of polyacid-modified resin composites (compomers) in neutral and acidic buffer solutions","volume":"26","year":"1999","unstructured":"Attin\n T,\n \n \n Buchalla\n W,\n \n \n Siewert\n C,\n &\n\t\t\t\t\t\tHellwigE (\n\t\t\t\t\t1999)\n\t\t\t\t\tFluoride release\/uptake of polyacid-modified resin composites (compomers) in neutral and acidic buffer solutionsJournal of Oral Rehabilitation26(\n\t\t\t\t\t5)\n\t\t\t\t\t388\u2013\n\t\t\t\t\t393. https:\/\/dx.doi.org\/10.1046\/j.1365-2842.1999.00413.x"},{"issue":"1","key":"i1559-2863-46-6-680-b11","series-title":"Operative Dentistry","first-page":"20","article-title":"Fluoride release from three glass ionomers, a compomer, and a composite resin in water, artificial saliva, and lactic acid","volume":"25","year":"2000","unstructured":"Karantakis\n P,\n \n \n Helvatjoglou-Antoniades\n M,\n \n \n Theodoridou-Pahini\n S,\n &\n\t\t\t\t\t\tPapadogiannisY (\n\t\t\t\t\t2000)\n\t\t\t\t\tFluoride release from three glass ionomers, a compomer, and a composite resin in water, artificial saliva, and lactic acidOperative Dentistry25(\n\t\t\t\t\t1)\n\t\t\t\t\t20\u2013\n\t\t\t\t\t25."},{"issue":"3","key":"i1559-2863-46-6-680-b12","series-title":"Dental Materials","first-page":"343","article-title":"Review on fluoride-releasing restorative materials -fluoride release and uptake characteristics, antibacterial activity and influence on caries formation","volume":"23","year":"2007","unstructured":"Wiegand\n A,\n \n \n Buchalla\n W,\n &\n\t\t\t\t\t\tAttinT (\n\t\t\t\t\t2007)\n\t\t\t\t\tReview on fluoride-releasing restorative materials -fluoride release and uptake characteristics, antibacterial activity and influence on caries formationDental Materials23(\n\t\t\t\t\t3)\n\t\t\t\t\t343\u2013\n\t\t\t\t\t362. https:\/\/dx.doi.org\/10.1016\/j.dental.2006.01.022"},{"issue":"1","key":"i1559-2863-46-6-680-b13","series-title":"Dental Materials","first-page":"32","article-title":"The recharge of esthetic dental restorative materials with fluoride in vitro-two years\u2019 results","volume":"19","year":"2003","unstructured":"Preston\n AJ,\n \n \n Agalamanyi\n EA,\n \n \n Higham\n SM,\n &\n\t\t\t\t\t\tMairLH (\n\t\t\t\t\t2003)\n\t\t\t\t\tThe recharge of esthetic dental restorative materials with fluoride in vitro-two years\u2019 resultsDental Materials19(\n\t\t\t\t\t1)\n\t\t\t\t\t32\u2013\n\t\t\t\t\t37. https:\/\/dx.doi.org\/10.1016\/s0109-5641(02)00011-8"},{"issue":"1","key":"i1559-2863-46-6-680-b14","series-title":"Journal of Dentistry","first-page":"43","article-title":"Sorption and solubility of resin-based restorative dental materials","volume":"31","year":"2003","unstructured":"Toledano\n M,\n \n \n Osorio\n R,\n \n \n Osorio\n E,\n \n \n Fuentes\n V,\n \n \n Prati\n C,\n &\n\t\t\t\t\t\tGarcia-GodoyF (\n\t\t\t\t\t2003)\n\t\t\t\t\tSorption and solubility of resin-based restorative dental materialsJournal of Dentistry31(\n\t\t\t\t\t1)\n\t\t\t\t\t43\u2013\n\t\t\t\t\t50. https:\/\/dx.doi.org\/10.1016\/s0300-5712(02) 00083-0"},{"issue":"14","key":"i1559-2863-46-6-680-b15","series-title":"Biomaterials","first-page":"2451","article-title":"Compressive strength, fluoride release and recharge of fluoride-releasing materials","volume":"24","year":"2003","unstructured":"Xu\n X\n &\n\t\t\t\t\t\tBurgessJO (\n\t\t\t\t\t2003)\n\t\t\t\t\tCompressive strength, fluoride release and recharge of fluoride-releasing materialsBiomaterials24(\n\t\t\t\t\t14)\n\t\t\t\t\t2451\u2013\n\t\t\t\t\t2461. https:\/\/dx.doi.org\/10.1016\/s0142-9612(02)00638-5"},{"issue":"4","key":"i1559-2863-46-6-680-b16","series-title":"Caries Research","first-page":"281","article-title":"Effect of tooth-bound fluoride on enamel demineralization\/remineralization in vitro","volume":"34","year":"2000","unstructured":"Takagi\n S,\n \n \n Liao\n H,\n &\n\t\t\t\t\t\tChowLC (\n\t\t\t\t\t2000)\n\t\t\t\t\tEffect of tooth-bound fluoride on enamel demineralization\/remineralization in vitroCaries Research34(\n\t\t\t\t\t4)\n\t\t\t\t\t281\u2013\n\t\t\t\t\t288. https:\/\/dx.doi.org\/10.1159\/000016603"},{"issue":"2","key":"i1559-2863-46-6-680-b17","series-title":"Journal of Clinical Periodontology","first-page":"105","article-title":"Topical application of fluorides on teeth. New concepts of mechanisms of interaction","volume":"20","year":"1993","unstructured":"R\u00f8lla\n G,\n \n \n \u00d8gaard\n B,\n &\n\t\t\t\t\t\tCruzRA (\n\t\t\t\t\t1993)\n\t\t\t\t\tTopical application of fluorides on teeth. New concepts of mechanisms of interactionJournal of Clinical Periodontology20(\n\t\t\t\t\t2)\n\t\t\t\t\t105\u2013\n\t\t\t\t\t108. https:\/\/dx.doi.org\/10.1111\/j.1600-051x.1993.tb00323.x"},{"issue":"6","key":"i1559-2863-46-6-680-b18","series-title":"Caries Research","first-page":"463","article-title":"In vitro enamel and cementum fluoride uptake from three fluoride-containing composites","volume":"32","year":"1998","unstructured":"Kawai\n K,\n \n \n Tantbirojn\n D,\n \n \n Kamalawat\n AS,\n \n \n Hasegawa\n T,\n &\n\t\t\t\t\t\tRetiefDH (\n\t\t\t\t\t1998)\n\t\t\t\t\tIn vitro enamel and cementum fluoride uptake from three fluoride-containing compositesCaries Research32(\n\t\t\t\t\t6)\n\t\t\t\t\t463\u2013\n\t\t\t\t\t469. https:\/\/dx.doi.org\/10.1159\/000016488"},{"issue":"1","key":"i1559-2863-46-6-680-b19","series-title":"Operative Dentistry","first-page":"4","article-title":"In vitro caries inhibition effects by conventional and resin-modified glass-ionomer restorations","volume":"22","year":"1997","unstructured":"Tarn\n LE,\n \n \n Chan\n GP,\n &\n\t\t\t\t\t\tYimD (\n\t\t\t\t\t1997)\n\t\t\t\t\tIn vitro caries inhibition effects by conventional and resin-modified glass-ionomer restorationsOperative Dentistry22(\n\t\t\t\t\t1)\n\t\t\t\t\t4\u2013\n\t\t\t\t\t14."},{"issue":"5","key":"i1559-2863-46-6-680-b20","series-title":"Operative Dentistry","first-page":"578","article-title":"Demineralization inhibition of direct tooth-colored restorative materials","volume":"29","year":"2004","unstructured":"Gonzalez\n EH,\n \n \n Yap\n AU\n &\n\t\t\t\t\t\tHsuSC (\n\t\t\t\t\t2004)\n\t\t\t\t\tDemineralization inhibition of direct tooth-colored restorative materialsOperative Dentistry29(\n\t\t\t\t\t5)\n\t\t\t\t\t578\u2013\n\t\t\t\t\t585."},{"issue":"12","key":"i1559-2863-46-6-680-b21","series-title":"Journal of Oral Rehabilitation","first-page":"1216","article-title":"Inhibition of demineralization in vitro around fluoride releasing materials","volume":"30","year":"2003","unstructured":"Dionysopoulos\n P,\n \n \n Kotsanos\n N,\n \n \n Koliniotou-Koubia\n E,\n &\n\t\t\t\t\t\tTolidisK (\n\t\t\t\t\t2003)\n\t\t\t\t\tInhibition of demineralization in vitro around fluoride releasing materialsJournal of Oral Rehabilitation30(\n\t\t\t\t\t12)\n\t\t\t\t\t1216\u2013\n\t\t\t\t\t1222. https:\/\/dx.doi.org\/10.1111\/j.1365-2842.2003.01079.x"},{"issue":"5","key":"i1559-2863-46-6-680-b22","series-title":"Operative Dentistry","first-page":"524","article-title":"Fluoride releasing materials: Their anti-cariogenic properties tested in in vitro caries models","volume":"29","year":"2004","unstructured":"Sa\n LT,\n \n \n Gonzalez-Cabezas\n C,\n \n \n Cochran\n MA,\n \n \n Fontana\n M,\n \n \n Matis\n BA,\n &\n\t\t\t\t\t\tMooreBK (\n\t\t\t\t\t2004)\n\t\t\t\t\tFluoride releasing materials: Their anti-cariogenic properties tested in in vitro caries modelsOperative Dentistry29(\n\t\t\t\t\t5)\n\t\t\t\t\t524\u2013\n\t\t\t\t\t531."},{"issue":"2","key":"i1559-2863-46-6-680-b23","series-title":"Journal of Oral Rehabilitation","first-page":"178","article-title":"Effect of fluoride-releasing adhesive system on decalcified dentin","volume":"30","year":"2003","unstructured":"Itota\n T,\n \n \n Torii\n Y,\n \n \n Nakabo\n S,\n \n \n Tashiro\n Y,\n \n \n Konishi\n N,\n \n \n Nagamine\n M,\n &\n\t\t\t\t\t\tYoshiyamaM (\n\t\t\t\t\t2003)\n\t\t\t\t\tEffect of fluoride-releasing adhesive system on decalcified dentinJournal of Oral Rehabilitation30(\n\t\t\t\t\t2)\n\t\t\t\t\t178\u2013\n\t\t\t\t\t183. https:\/\/dx.doi.org\/10.1046\/j.1365-2842.2003.00985.x"},{"issue":"6","key":"i1559-2863-46-6-680-b24","series-title":"Journal of Oral Rehabilitation","first-page":"523","article-title":"Inhibition of artificial secondary caries by fluoride-releasing adhesives on root dentin","volume":"29","year":"2002","unstructured":"Itota\n T,\n \n \n Nakabo\n S,\n \n \n Iwai\n Y,\n \n \n Konishi\n N,\n \n \n Nagamine\n M,\n &\n\t\t\t\t\t\tToriiY (\n\t\t\t\t\t2002)\n\t\t\t\t\tInhibition of artificial secondary caries by fluoride-releasing adhesives on root dentinJournal of Oral Rehabilitation29(\n\t\t\t\t\t6)\n\t\t\t\t\t523\u2013\n\t\t\t\t\t527. https:\/\/dx.doi.org\/10.1046\/j.1365-2842.2002.00858.x"},{"issue":"5","key":"i1559-2863-46-6-680-b25","series-title":"Operative Dentistry","first-page":"445","article-title":"Effect of adhesives on the inhibition of secondary caries around compomer restorations","volume":"26","year":"2001","unstructured":"Itota\n T,\n \n \n Nakabo\n S,\n \n \n Iwai\n Y,\n \n \n Konishi\n N,\n \n \n Nagamine\n M,\n \n \n Torii\n Y,\n &\n\t\t\t\t\t\tYoshiyamaM (\n\t\t\t\t\t2001)\n\t\t\t\t\tEffect of adhesives on the inhibition of secondary caries around compomer restorationsOperative Dentistry26(\n\t\t\t\t\t5)\n\t\t\t\t\t445\u2013\n\t\t\t\t\t450."},{"issue":"11","key":"i1559-2863-46-6-680-b26","series-title":"Journal of Oral Rehabilitation","first-page":"814","article-title":"Artificial caries formation around fluoride-releasing restorations in roots","volume":"25","year":"1998","unstructured":"Dionysopoulos\n P,\n \n \n Kotsanos\n N,\n \n \n Papadogiannis\n Y,\n &\n\t\t\t\t\t\tKonstantinidisA (\n\t\t\t\t\t1998)\n\t\t\t\t\tArtificial caries formation around fluoride-releasing restorations in rootsJournal of Oral Rehabilitation25(\n\t\t\t\t\t11)\n\t\t\t\t\t814\u2013\n\t\t\t\t\t820. https:\/\/dx.doi.org\/10.1046\/j.1365-2842.1998.00315.x"},{"issue":"2","key":"i1559-2863-46-6-680-b27","series-title":"Journal of Biomedical Material Research B Applied Biomaterials","first-page":"725","article-title":"Chemical or microbiological models of secondary caries development around different dental restorative materials","volume":"74","year":"2005","unstructured":"Lobo\n MM,\n \n \n Gon\u00e7alves\n RB,\n \n \n Ambrosano\n GM,\n &\n\t\t\t\t\t\tPimentaLA (\n\t\t\t\t\t2005)\n\t\t\t\t\tChemical or microbiological models of secondary caries development around different dental restorative materialsJournal of Biomedical Material Research B Applied Biomaterials74(\n\t\t\t\t\t2)\n\t\t\t\t\t725\u2013\n\t\t\t\t\t731. https:\/\/dx.doi.org\/10.1002\/jbm.b.30253"},{"issue":"5\u20136","key":"i1559-2863-46-6-680-b28","series-title":"Journal of Dentistry","first-page":"505","article-title":"In vitro secondary caries inhibition around fluoride releasing materials","volume":"26","year":"1998","unstructured":"Pereira\n PN,\n \n \n Inokoshi\n S,\n &\n\t\t\t\t\t\tTagamiJ (\n\t\t\t\t\t1998)\n\t\t\t\t\tIn vitro secondary caries inhibition around fluoride releasing materialsJournal of Dentistry26(\n\t\t\t\t\t5\u20136)\n\t\t\t\t\t505\u2013\n\t\t\t\t\t510. https:\/\/dx.doi.org\/10.1016\/s0300-5712(98)00008-6"},{"issue":"10","key":"i1559-2863-46-6-680-b29","series-title":"Journal of the American Dental Association","first-page":"1459","article-title":"Clinical performance and caries inhibition of resin-modified glass ionomer cement and amalgam restorations","volume":"130","year":"1999","unstructured":"Donly\n KJ,\n \n \n Segura\n A,\n \n \n Kanellis\n M,\n &\n\t\t\t\t\t\tEricksonRL (\n\t\t\t\t\t1999)\n\t\t\t\t\tClinical performance and caries inhibition of resin-modified glass ionomer cement and amalgam restorationsJournal of the American Dental Association130(\n\t\t\t\t\t10)\n\t\t\t\t\t1459\u2013\n\t\t\t\t\t1466. https:\/\/dx.doi.org\/10.14219\/jada.archive.1999.0056"},{"issue":"1","key":"i1559-2863-46-6-680-b30","series-title":"Clinical Oral Investigations","first-page":"31","article-title":"Two-year clinical performance of glass ionomer and resin composite restorations in xerostomic head- and neck-irradiated cancer patients","volume":"15","year":"2011","unstructured":"De Moor\n RJ,\n \n \n Stassen\n IG,\n \n \n van \u2019t Veldt\n Y,\n \n \n Torbeyns\n D,\n &\n\t\t\t\t\t\tHommezGM (\n\t\t\t\t\t2011)\n\t\t\t\t\tTwo-year clinical performance of glass ionomer and resin composite restorations in xerostomic head- and neck-irradiated cancer patientsClinical Oral Investigations15(\n\t\t\t\t\t1)\n\t\t\t\t\t31\u2013\n\t\t\t\t\t38. https:\/\/dx.doi.org\/10.1007\/s00784-009-0355-4"},{"issue":"5","key":"i1559-2863-46-6-680-b31","series-title":"Operative Dentistry","first-page":"430","article-title":"A clinical comparison of glass-ionomer, resin-modified glass ionomer and resin-composite restorations in the treatment of cervical caries in xerostomic head and neck radiation patients","volume":"27","year":"2002","unstructured":"McComb\n D,\n \n \n Ericson\n RL,\n \n \n Maxymiw\n WG,\n &\n\t\t\t\t\t\tWoodRE (\n\t\t\t\t\t2002)\n\t\t\t\t\tA clinical comparison of glass-ionomer, resin-modified glass ionomer and resin-composite restorations in the treatment of cervical caries in xerostomic head and neck radiation patientsOperative Dentistry27(\n\t\t\t\t\t5)\n\t\t\t\t\t430\u2013\n\t\t\t\t\t437."},{"issue":"3","key":"i1559-2863-46-6-680-b32","series-title":"Operative Dentistry","first-page":"94","article-title":"A clinical comparison of glass ionomer (polyalkenoate) and silver amalgam restorations in the treatment of Class 5 caries in xerostomic head and neck cancer patients","volume":"18","year":"1993","unstructured":"Wood\n RE,\n \n \n Maxymiw\n WG,\n &\n\t\t\t\t\t\tMcCombD (\n\t\t\t\t\t1993)\n\t\t\t\t\tA clinical comparison of glass ionomer (polyalkenoate) and silver amalgam restorations in the treatment of Class 5 caries in xerostomic head and neck cancer patientsOperative Dentistry18(\n\t\t\t\t\t3)\n\t\t\t\t\t94\u2013\n\t\t\t\t\t102."},{"issue":"Special Issue A","key":"i1559-2863-46-6-680-b33","series-title":"Journal of Dental Research","article-title":"A clinical comparison of restorative materials for caries in xerostomic patients","volume":"78","year":"1999","unstructured":"Haveman\n C,\n \n \n Burgess\n J,\n &\n\t\t\t\t\t\tSummittJB (\n\t\t\t\t\t1999)\n\t\t\t\t\tA clinical comparison of restorative materials for caries in xerostomic patientsJournal of Dental Research78(\n\t\t\t\t\tSpecial Issue A)\n\t\t\t\t\tAbstract #1441."},{"issue":"2","key":"i1559-2863-46-6-680-b34","series-title":"Journal of Dental Research","first-page":"628","article-title":"Glass-ionomer restoratives: A systematic review of a secondary caries treatment effect","volume":"78","year":"1999","unstructured":"Randall\n RC\n &\n\t\t\t\t\t\tWilsonNH (\n\t\t\t\t\t1999)\n\t\t\t\t\tGlass-ionomer restoratives: A systematic review of a secondary caries treatment effectJournal of Dental Research78(\n\t\t\t\t\t2)\n\t\t\t\t\t628\u2013\n\t\t\t\t\t637."},{"issue":"12","key":"i1559-2863-46-6-680-b35","series-title":"Dental Materials","first-page":"1757","article-title":"Characterization of the bioactivity of two commercial composites","volume":"35","year":"2019","unstructured":"Tiskaya\n M,\n \n \n Al-Eesa\n NA,\n \n \n Wong\n FSL,\n &\n\t\t\t\t\t\tHillRG (\n\t\t\t\t\t2019)\n\t\t\t\t\tCharacterization of the bioactivity of two commercial compositesDental Materials35(\n\t\t\t\t\t12)\n\t\t\t\t\t1757\u2013\n\t\t\t\t\t1768. https:\/\/dx.doi.org\/10.1016\/j.dental.2019.10.004."},{"key":"i1559-2863-46-6-680-b36","series-title":"Journal of Dentistry","first-page":"103474","article-title":"Evaluation of F, Ca, and P release and microhardness of eleven ion-leaching restorative materials and the recharge efficacy using a new Ca\/P containing fluoride varnish","volume":"102","year":"2018","unstructured":"Ruengrungsom\n C,\n \n \n Burrow\n MF,\n \n \n Parashos\n P,\n &\n\t\t\t\t\t\tPalamaraJEA (\n\t\t\t\t\t2018)\n\t\t\t\t\tEvaluation of F, Ca, and P release and microhardness of eleven ion-leaching restorative materials and the recharge efficacy using a new Ca\/P containing fluoride varnishJournal of Dentistry102(\n\t\t\t\t\tNovember)\n\t\t\t\t\t103474. https:\/\/dx.doi.org\/10.1016\/j.jdent.2020.103474."},{"key":"i1559-2863-46-6-680-b37","series-title":"American Journal of Dentistry","first-page":"166","article-title":"Dentin and enamel demineralization inhibition at restoration margins of Vitremer, Z100 and Cention N","volume":"31","year":"2018","unstructured":"Donly\n KJ\n &\n\t\t\t\t\t\tLiuJA (\n\t\t\t\t\t2018)\n\t\t\t\t\tDentin and enamel demineralization inhibition at restoration margins of Vitremer, Z100 and Cention NAmerican Journal of Dentistry31:\n\t\t\t\t\t166\u2013\n\t\t\t\t\t168."},{"key":"i1559-2863-46-6-680-b38","series-title":"Factors Relating to Demineralization and Remineralization of the Teeth","first-page":"23","article-title":"Enhancement of remineralization in vitro and in vivo","year":"1986","unstructured":"Featherstone\n JDB\n \n (\n\t\t\t\t\t1986)\n\t\t\t\t\tEnhancement of remineralization in vitro and in vivo.\n\t\t\t\t\tIn:LeachSA(ed)Factors Relating to Demineralization and Remineralization of the TeethIRL Press,\n\t\t\t\t\tOxford23\u2013\n\t\t\t\t\t34."},{"issue":"4","key":"i1559-2863-46-6-680-b39","series-title":"Dental Materials Journal","first-page":"608","article-title":"Monomer conversion, dimensional stability, biaxial flexural strength, and fluoride release of resin-based restorative material containing alkaline fillers","volume":"39","year":"2020","unstructured":"Panpisut\n P\n &\n\t\t\t\t\t\tToneluckA (\n\t\t\t\t\t2020)\n\t\t\t\t\tMonomer conversion, dimensional stability, biaxial flexural strength, and fluoride release of resin-based restorative material containing alkaline fillersDental Materials Journal39(\n\t\t\t\t\t4)\n\t\t\t\t\t608\u2013\n\t\t\t\t\t615. https:\/\/dx.doi.org\/10.4012\/dmj.2019-020"},{"issue":"2","key":"i1559-2863-46-6-680-b40","series-title":"Dental Materials","first-page":"335","article-title":"A randomized controlled evaluation of posterior resin restorations of an altered resin modified glass-ionomer cement with claimed bioactivity","volume":"35","year":"2019","unstructured":"van Dijken\n JWV,\n \n \n Pallesen\n U,\n &\n\t\t\t\t\t\tBenettiA (\n\t\t\t\t\t2019)\n\t\t\t\t\tA randomized controlled evaluation of posterior resin restorations of an altered resin modified glass-ionomer cement with claimed bioactivityDental Materials35(\n\t\t\t\t\t2)\n\t\t\t\t\t335\u2013\n\t\t\t\t\t343. https:\/\/dx.doi.org\/10.1016\/j.dental.2018.11.027"},{"issue":"Special Issue A","key":"i1559-2863-46-6-680-b41","series-title":"Journal of Dental Research","article-title":"Clinical evaluation of an amalgam replacement restorative material: 24-month recall","volume":"98","year":"2019","unstructured":"Robles\n A,\n \n \n Fu\n C,\n \n \n Lawson\n NC,\n &\n\t\t\t\t\t\tBurgessJ (\n\t\t\t\t\t2019)\n\t\t\t\t\tClinical evaluation of an amalgam replacement restorative material: 24-month recallJournal of Dental Research98(\n\t\t\t\t\tSpecial Issue A)\n\t\t\t\t\tAbstract #0736."}],"container-title":["Operative Dentistry"],"original-title":[],"link":[{"URL":"https:\/\/operative-dentistry.kglmeridian.com\/view\/journals\/odnt\/46\/6\/article-p680.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/meridian.allenpress.com\/operative-dentistry\/article-pdf\/46\/6\/680\/3056064\/i1559-2863-46-6-680.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/operative-dentistry.kglmeridian.com\/downloadpdf\/journals\/odnt\/46\/6\/article-p680.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/operative-dentistry.kglmeridian.com\/downloadpdf\/journals\/odnt\/46\/6\/article-p680.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:46:33Z","timestamp":1758933993000},"score":1,"resource":{"primary":{"URL":"https:\/\/operative-dentistry.kglmeridian.com\/view\/journals\/odnt\/46\/6\/article-p680.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":41,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.2341\/20-074-l","relation":{},"ISSN":["1559-2863","0361-7734"],"issn-type":[{"type":"electronic","value":"1559-2863"},{"type":"print","value":"0361-7734"}],"subject":[],"published":{"date-parts":[[2021]]}}}