{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:04:09Z","timestamp":1785449049001,"version":"3.56.0"},"reference-count":46,"publisher":"Operative Dentistry","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"abstract":"SUMMARY<\/jats:title>\n \n Objective<\/jats:title>\n To evaluate the success rate of direct pulp capping (DPC) with Biodentine in mature permanent teeth with carious vital pulp exposure compared to that of DPC with mineral trioxide aggregate (MTA) by means of a systematic review and meta-analysis.<\/jats:p>\n <\/jats:sec>\n \n Data Sources<\/jats:title>\n The two authors searched independently the literature published through July 31, 2020, in five electronic databases (PubMed, the Cochrane Central Register of Controlled Trials, Web of Science Core Collection, the Wiley Online Library, and the SCOPUS database).<\/jats:p>\n <\/jats:sec>\n \n Study Selection<\/jats:title>\n The research protocol was previously registered in the PROSPERO database (CRD42020192511). Clinical studies that met the inclusion criteria were chosen and independently screened by the authors.<\/jats:p>\n <\/jats:sec>\n \n Data Extraction<\/jats:title>\n A custom-designed spreadsheet was used to extract the data. The quality of each study was evaluated by means of the revised Cochrane risk of bias (ROB) tool or the ROB of nonrandomized studies of interventions tool.<\/jats:p>\n <\/jats:sec>\n \n Data Synthesis<\/jats:title>\n Three randomized controlled trials and one retrospective study met the inclusion criteria. Only one study had a high risk of bias. The included studies reported data on a total of 95 participants with an age range of 8\u201351 years. No significant difference was observed in the overall treatment outcome when comparing Biodentine with MTA (Risk ratio=1.00, 95% confidence interval [0.93\u20131.07], p<\/jats:italic>=1.00).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Biodentine had comparable clinical and radiographic success to that of MTA when used as a DPC agent in mature permanent teeth with carious vital pulp exposure. Additional high-quality studies are needed.<\/jats:p>\n <\/jats:sec>","DOI":"10.2341\/20-277-lit","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T16:01:14Z","timestamp":1651680074000},"page":"631-640","source":"Crossref","is-referenced-by-count":12,"title":["Biodentine or Mineral Trioxide Aggregate as Direct Pulp Capping Material in Mature Permanent Teeth with Carious Exposure? A Systematic Review and Meta-analysis"],"prefix":"10.2341","volume":"46","author":[{"given":"Sara","family":"Alsubait","sequence":"first","affiliation":[{"name":"*Sara Alsubait, Department of Restorative Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahd","family":"Aljarbou","sequence":"additional","affiliation":[{"name":"Fahd Aljarbou, King Saud University, Riyadh, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1188","reference":[{"issue":"5","key":"i1559-2863-46-6-631-b1","series-title":"Pediatric Clinics of North America","first-page":"1001","article-title":"Dental caries: An infectious and transmissible disease","volume":"47","year":"2000","unstructured":"Caufield\n PW\n &\n\t\t\t\t\t\tGriffenAL (\n\t\t\t\t\t2000)\n\t\t\t\t\tDental caries: An infectious and transmissible diseasePediatric Clinics of North America47(\n\t\t\t\t\t5)\n\t\t\t\t\t1001\u2013\n\t\t\t\t\t1019."},{"issue":"Special Issue C","key":"i1559-2863-46-6-631-b2","series-title":"Journal of Dental Research","first-page":"C35","article-title":"What constitutes dental caries? 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calcium-silicate-based restorative cement on pulp repairJournal of Dental Research91(\n\t\t\t\t\t12)\n\t\t\t\t\t1166\u2013\n\t\t\t\t\t1171."},{"issue":"6","key":"i1559-2863-46-6-631-b17","series-title":"International Endodontic Journal","first-page":"749","article-title":"Partial pulpotomy with two bioactive cements in permanent teeth of 6- to 18-year-old patients with signs and symptoms indicative of irreversible pulpitis: A noninferiority randomized controlled trial","volume":"52","year":"2019","unstructured":"Uesrichai\n N,\n \n \n Nirunsittirat\n A,\n \n \n Chuveera\n P,\n \n \n Srisuwan\n T,\n \n \n Sastraruji\n T,\n &\n\t\t\t\t\t\tChompu-InwaiP (\n\t\t\t\t\t2019)\n\t\t\t\t\tPartial pulpotomy with two bioactive cements in permanent teeth of 6- to 18-year-old patients with signs and symptoms indicative of irreversible pulpitis: A noninferiority randomized controlled trialInternational Endodontic 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pulp capping using bioceramic materials in mature permanent teeth with carious exposure: A pilot retrospective studyJournal of Endodontics43(\n\t\t\t\t\t10)\n\t\t\t\t\t1635\u2013\n\t\t\t\t\t1639."},{"issue":"3","key":"i1559-2863-46-6-631-b30","series-title":"Journal of Endodontics","first-page":"383","article-title":"Long-term pulpal and restorative outcomes of pulpotomy in mature permanent teeth","volume":"46","year":"2020","unstructured":"Tan\n SY,\n \n \n Yu\n VSH,\n \n \n Lim\n KC,\n \n \n Tan\n BCK,\n \n \n Neo\n CLJ,\n \n \n Shen\n L,\n &\n\t\t\t\t\t\tMesserHH (\n\t\t\t\t\t2020)\n\t\t\t\t\tLong-term pulpal and restorative outcomes of pulpotomy in mature permanent teethJournal of Endodontics46(\n\t\t\t\t\t3)\n\t\t\t\t\t383\u2013\n\t\t\t\t\t390."},{"issue":"6","key":"i1559-2863-46-6-631-b31","series-title":"International Endodontic Journal","first-page":"533","article-title":"Formation of a hard tissue barrier after experimental pulp capping or partial pulpotomy in humans: An updated systematic review","volume":"49","year":"2016","unstructured":"Fransson\n H,\n \n \n Wolf\n E,\n &\n\t\t\t\t\t\tPeterssonK (\n\t\t\t\t\t2016)\n\t\t\t\t\tFormation of a hard tissue barrier after experimental pulp capping or partial pulpotomy in humans: An updated systematic reviewInternational Endodontic Journal49(\n\t\t\t\t\t6)\n\t\t\t\t\t533\u2013\n\t\t\t\t\t542."},{"issue":"3","key":"i1559-2863-46-6-631-b32","series-title":"Journal of Biomedical Materials Research Part B: Applied Biomaterials","first-page":"1358","article-title":"Current trends and future perspectives of dental pulp capping materials: A systematic review","volume":"106","year":"2018","unstructured":"da Rosa\n WL,\n \n \n Cocco\n AR,\n \n \n Silva\n TMD,\n \n \n Mesquita\n LC,\n \n \n Galarca\n AD,\n \n \n Silva\n AFD,\n &\n\t\t\t\t\t\tPivaE (\n\t\t\t\t\t2018)\n\t\t\t\t\tCurrent trends and future perspectives of dental pulp capping materials: A systematic reviewJournal of Biomedical Materials Research Part B: Applied Biomaterials106(\n\t\t\t\t\t3)\n\t\t\t\t\t1358\u2013\n\t\t\t\t\t1368."},{"issue":"4","key":"i1559-2863-46-6-631-b33","series-title":"Journal of Biomaterials and Tissue Engineering","first-page":"323","article-title":"Biocompatibility and mineralization potential of ProRoot mineral trioxide aggregate and Biodentine on mesenchymal stem cells","volume":"6","year":"2016","unstructured":"Alsubait\n SA,\n \n \n Al-Fadda\n SS,\n \n \n Ababtain\n RA,\n \n \n Alghofaily\n MM,\n \n \n Abuelreich\n S,\n \n \n Anil\n S,\n \n \n Aldahmash\n A,\n &\n\t\t\t\t\t\tMahmoodA (\n\t\t\t\t\t2016)\n\t\t\t\t\tBiocompatibility and mineralization potential of ProRoot mineral trioxide aggregate and Biodentine on mesenchymal stem cellsJournal of Biomaterials and Tissue Engineering6(\n\t\t\t\t\t4)\n\t\t\t\t\t323\u2013\n\t\t\t\t\t328."},{"issue":"3","key":"i1559-2863-46-6-631-b34","series-title":"Journal of Contemporary Dental Practice","first-page":"336","article-title":"Comparative evaluation of push-out 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aggregate in dogsJournal of Endodontics40(\n\t\t\t\t\t9)\n\t\t\t\t\t1362\u2013\n\t\t\t\t\t1369."},{"issue":"2","key":"i1559-2863-46-6-631-b36","series-title":"Journal of Endodontics","first-page":"225","article-title":"Treatment outcomes of mineral trioxide aggregate pulpotomy in vital permanent teeth with carious pulp exposure: The retrospective study","volume":"43","year":"2017","unstructured":"Linsuwanont\n P,\n \n \n Wimonsutthikul\n K,\n \n \n Pothimoke\n U,\n &\n\t\t\t\t\t\tSantiwongB (\n\t\t\t\t\t2017)\n\t\t\t\t\tTreatment outcomes of mineral trioxide aggregate pulpotomy in vital permanent teeth with carious pulp exposure: The retrospective studyJournal of Endodontics43(\n\t\t\t\t\t2)\n\t\t\t\t\t225\u2013\n\t\t\t\t\t230."},{"issue":"11","key":"i1559-2863-46-6-631-b37","series-title":"Journal of Endodontics","first-page":"1862","article-title":"Spectrophotometric analysis of coronal tooth discoloration induced by various bioceramic cements and other endodontic materials","volume":"41","year":"2015","unstructured":"Kohli\n MR,\n \n \n Yamaguchi\n M,\n \n \n Setzer\n FC,\n &\n\t\t\t\t\t\tKarabucakB (\n\t\t\t\t\t2015)\n\t\t\t\t\tSpectrophotometric analysis of coronal tooth discoloration induced by various bioceramic cements and other endodontic materialsJournal of Endodontics41(\n\t\t\t\t\t11)\n\t\t\t\t\t1862\u2013\n\t\t\t\t\t1866."},{"issue":"7","key":"i1559-2863-46-6-631-b38","series-title":"Journal of Endodontics","first-page":"1157","article-title":"Color stability of teeth restored with Biodentine: A 6-month in vitro study","volume":"41","year":"2015","unstructured":"Vall\u00e9s\n M,\n \n \n Roig\n M,\n \n \n Duran-Sindreu\n F,\n \n \n Mart\u00ednez\n S,\n &\n\t\t\t\t\t\tMercad\u00e9M (\n\t\t\t\t\t2015)\n\t\t\t\t\tColor stability of teeth restored with Biodentine: A 6-month in vitro studyJournal of Endodontics41(\n\t\t\t\t\t7)\n\t\t\t\t\t1157\u2013\n\t\t\t\t\t1160."},{"issue":"3","key":"i1559-2863-46-6-631-b39","series-title":"Journal of Endodontics","first-page":"436","article-title":"Color stability of white mineral trioxide aggregate in contact with hypochlorite solution","volume":"40","year":"2014","unstructured":"Camilleri\n J\n \n (\n\t\t\t\t\t2014)\n\t\t\t\t\tColor stability of white mineral trioxide aggregate in contact with hypochlorite solutionJournal of Endodontics40(\n\t\t\t\t\t3)\n\t\t\t\t\t436\u2013\n\t\t\t\t\t440."},{"issue":"8","key":"i1559-2863-46-6-631-b40","series-title":"Journal of Endodontics","first-page":"1235","article-title":"Assessment of color stability of white mineral trioxide aggregate angelus and bismuth oxide in contact with tooth structure","volume":"40","year":"2014","unstructured":"Marciano\n MA,\n \n \n Costa\n RM,\n \n \n Camilleri\n J,\n \n \n Mondelli\n RFL,\n \n \n Guimaraes\n BM,\n &\n\t\t\t\t\t\tDuarteMAH (\n\t\t\t\t\t2014)\n\t\t\t\t\tAssessment of color stability of white mineral trioxide aggregate angelus and bismuth oxide in contact with tooth structureJournal of 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Is it worth it?","volume":"68","year":"1989","unstructured":"Stanley\n HR\n \n (\n\t\t\t\t\t1989)\n\t\t\t\t\tPulp capping: Conserving the dental pulp\u2014can it be done? Is it worth it?Oral Surgery Oral Medicine Oral Pathology68(\n\t\t\t\t\t5)\n\t\t\t\t\t628\u2013\n\t\t\t\t\t639."},{"issue":"4","key":"i1559-2863-46-6-631-b43","series-title":"Quintessence International","first-page":"261","article-title":"An in vivo evaluation of hemorrhage control using sodium hypochlorite and direct capping with a one-or two-component adhesive system in exposed nonhuman primate pulps","volume":"33","year":"2002","unstructured":"Hafez\n AA,\n \n \n Cox\n CF,\n \n \n Tarim\n B,\n \n \n Otsuki\n M,\n &\n\t\t\t\t\t\tAkimotoN (\n\t\t\t\t\t2002)\n\t\t\t\t\tAn in vivo evaluation of hemorrhage control using sodium hypochlorite and direct capping with a one-or two-component adhesive system in exposed nonhuman primate pulpsQuintessence International33(\n\t\t\t\t\t4)\n\t\t\t\t\t261\u2013\n\t\t\t\t\t272."},{"issue":"6","key":"i1559-2863-46-6-631-b44","series-title":"International Dental Journal","first-page":"329","article-title":"Sodium hypochlorite in endodontics: An update review","volume":"58","year":"2008","unstructured":"Mohammadi\n Z\n \n (\n\t\t\t\t\t2008)\n\t\t\t\t\tSodium hypochlorite in endodontics: An update reviewInternational Dental Journal58(\n\t\t\t\t\t6)\n\t\t\t\t\t329\u2013\n\t\t\t\t\t341."},{"issue":"3","key":"i1559-2863-46-6-631-b45","series-title":"Oral Surgery Oral Medicine Oral Pathology","first-page":"340","article-title":"The effects of surgical exposures of dental pulps in germ-free and conventional laboratory rats","volume":"20","year":"1965","unstructured":"Kakehashi\n S,\n \n \n Stanley\n HR,\n &\n\t\t\t\t\t\tFitzgeraldRJ (\n\t\t\t\t\t1965)\n\t\t\t\t\tThe effects of surgical exposures of dental pulps in germ-free and conventional laboratory ratsOral Surgery Oral Medicine Oral Pathology20(\n\t\t\t\t\t3)\n\t\t\t\t\t340\u2013\n\t\t\t\t\t349."},{"issue":"9","key":"i1559-2863-46-6-631-b46","series-title":"Journal of Endodontics","first-page":"525","article-title":"Pulp capping of carious exposures: Treatment outcome after 5 and 10 years: A retrospective study","volume":"26","year":"2000","unstructured":"Barthel\n CR,\n \n \n Rosenkranz\n B,\n \n \n Leuenberg\n A,\n &\n\t\t\t\t\t\tRouletJF (\n\t\t\t\t\t2000)\n\t\t\t\t\tPulp capping of carious exposures: Treatment outcome after 5 and 10 years: A retrospective studyJournal of Endodontics26(\n\t\t\t\t\t9)\n\t\t\t\t\t525\u2013\n\t\t\t\t\t528."}],"container-title":["Operative Dentistry"],"original-title":[],"link":[{"URL":"https:\/\/operative-dentistry.kglmeridian.com\/view\/journals\/odnt\/46\/6\/article-p631.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/meridian.allenpress.com\/operative-dentistry\/article-pdf\/46\/6\/631\/3160517\/i1559-2863-46-6-631.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/operative-dentistry.kglmeridian.com\/downloadpdf\/journals\/odnt\/46\/6\/article-p631.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/operative-dentistry.kglmeridian.com\/downloadpdf\/journals\/odnt\/46\/6\/article-p631.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:46:12Z","timestamp":1758933972000},"score":1,"resource":{"primary":{"URL":"https:\/\/operative-dentistry.kglmeridian.com\/view\/journals\/odnt\/46\/6\/article-p631.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":46,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.2341\/20-277-lit","relation":{},"ISSN":["1559-2863","0361-7734"],"issn-type":[{"value":"1559-2863","type":"electronic"},{"value":"0361-7734","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]}}}