{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:02:32Z","timestamp":1759017752089,"version":"3.44.0"},"reference-count":29,"publisher":"Operative Dentistry","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n        <jats:sec>\n          <jats:title>Purpose:<\/jats:title>\n          <jats:p>To evaluate the <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> performance of an intraoral camera (IC), visual examination using the Thylstrup and Fejerskov Index (TFI), and quantitative light-induced fluorescence (QLF) to detect and quantify enamel fluorosis (EF).<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>Methods and Materials:<\/jats:title>\n          <jats:p>Calibrated examiners performed IC-qualitative (ICQual), TFI, IC-quantitative (ICQuant), and QLF (Area, Fluorescence loss [\u0394F], and \u0394Q: Area\u00d7\u0394F) on 150 extracted teeth <jats:italic>in vitro<\/jats:italic> and 150 children <jats:italic>in vivo<\/jats:italic>. Polarized light microscopy (PLM) was the gold standard for the <jats:italic>in vitro<\/jats:italic> phase. Cross tabulation, agreement, correlation, comparison of means from quantitative measures, sensitivity, and specificity were calculated for TFI, QLF, ICQual, and ICQuant. For the <jats:italic>in vivo<\/jats:italic> phase, TFI scores were cross tabulated with ICQuant and ICQual, and Kendall's Tau was used to measure correlation.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>Results:<\/jats:title>\n          <jats:p>Agreements of TFI and ICQual with PLM were 53.77% and 47.17%, respectively. Correlation coefficients for QLF (area, \u0394F, \u0394Q) and ICQuant with PLM scores were 0.47, 0.56, 0.51, 0.46, respectively. Sensitivity\/specificity for TFI, ICQual, ICQuant, and \u0394Q were 0.86\/0.58, 0.86\/0.62, 0.86\/0.58, and 1.00\/0.13, respectively. For the <jats:italic>in vivo<\/jats:italic> phase, correlations of ICQual and ICQuant with TFI were 0.55 and 0.52, respectively. Quantitative measurements of ICQuant by TFI scores showed consistent separation in means, while those for QLF were neither as clear nor as consistent.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>Conclusion:<\/jats:title>\n          <jats:p>All methods were able to detect and quantify enamel fluorosis. However, there were consistent and significant differences among them.<\/jats:p>\n        <\/jats:sec>","DOI":"10.2341\/24-137-c","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T01:19:51Z","timestamp":1749431991000},"page":"311-323","source":"Crossref","is-referenced-by-count":0,"title":["The Use of Intraoral Camera, Quantitative Light Fluorescence, and Visual Examinations for the Detection and Assessment of Enamel Fluorosis"],"prefix":"10.2341","volume":"50","author":[{"given":"N","family":"Abogazalah","sequence":"first","affiliation":[{"name":"*Naif Abogazalah, BDS, MSD, PhD, Department of Restorative Dental Sciences, King Faisal University College of Dentistry, Hofuf, Alahssa, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Al Dehailan","sequence":"additional","affiliation":[{"name":"Laila Al Dehailan, BDS, MSD, PhD, Department of Restorative Dental Sciences, College of Dentistry, Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A-E","family":"Soto-Rojas","sequence":"additional","affiliation":[{"name":"Armando-Ernesto Soto-Rojas, DDS, MPH, Department of Dental Public Health and Dental Informatics, Indiana University School of Dentistry, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Ando","sequence":"additional","affiliation":[{"name":"Masatoshi Ando, PhD, DDS, BS, Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Martignon","sequence":"additional","affiliation":[{"name":"Stefania Martignon, BDS, PhD, UNICA - Caries Research Unit, Research Department, Universidad El Bosque, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Eggertsson","sequence":"additional","affiliation":[{"name":"Hafsteinn Eggertsson, DDS, private practice, Eugene, OR, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Shone","sequence":"additional","affiliation":[{"name":"Devin Shone, DDS, private practice, Bloomington, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E-A","family":"Martinez-Mier","sequence":"additional","affiliation":[{"name":"Esperanza-Angeles Martinez-Mier, DDS, MSD, PhD, Department of Dental Public Health and Dentail Informatics, Indiana University School of Dentistry, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1188","reference":[{"issue":"2","key":"b1","series-title":"Community Dentistry and Oral Epidemiology","first-page":"140","article-title":"Overview and quality assurance for the National Health and Nutrition Examination Survey (NHANES) oral health component, 1999-2002","volume":"35","author":"Dye\n              B","year":"2007","unstructured":"Dye\n              B\n            , BarkerL, SelwitzR, LewisB, WuT, FryarC, OstchegaY, BeltranE, & LeyE (2007) Overview and quality assurance for the National Health and Nutrition Examination Survey (NHANES) oral health component, 1999-2002Community Dentistry and Oral Epidemiology35(2) 140-151."},{"issue":"53","key":"b2","series-title":"NCHS Data Brief","first-page":"1","article-title":"Prevalence and severity of dental fluorosis in the United States, 1999-2004","author":"Beltr\u00e1n-Aguilar\n              ED","year":"2010","unstructured":"Beltr\u00e1n-Aguilar\n              ED\n            , LBarker, & EADye (2010) Prevalence and severity of dental fluorosis in the United States, 1999-2004NCHS Data Brief (53) 1-8."},{"issue":"4","key":"b3","series-title":"JDR Clinical & Translational Research","first-page":"298","article-title":"Dental fluorosis trends in US oral health surveys: 1986 to 2012","volume":"4","author":"Neurath\n              C","year":"2019","unstructured":"Neurath\n              C\n            , LimebackH, OsmunsonB, ConnettM, KanterV, & WellsC (2019) Dental fluorosis trends in US oral health surveys: 1986 to 2012JDR Clinical & Translational Research4(4) 298-308."},{"issue":"1","key":"b4","series-title":"Journal of Dental Hygiene","first-page":"23","article-title":"Dental fluorosis over time: A comparison of national health and nutrition examination survey data from 2001-2002 and 2011-2012","volume":"92","author":"Wiener\n              RC","year":"2018","unstructured":"Wiener\n              RC\n            , ShenC, FindleyP, TanX, & SambamoorthiU (2018) Dental fluorosis over time: A comparison of national health and nutrition examination survey data from 2001-2002 and 2011-2012Journal of Dental Hygiene92(1) 23-29."},{"issue":"183","key":"b5","series-title":"Vital and Health Statistics, Series 2 Data evaulation and methods research","first-page":"1","article-title":"Data quality evaluation of the dental fluorosis clinical assessment data from the National Health and Nutrition Examination Survey, 1999-2004 and 2011-2016","author":"National Center for Health Statistics (US) Division of Health and Nutrition Examination Surveys","year":"2019","unstructured":"National Center for Health Statistics (US) Division of Health and Nutrition Examination Surveys\n           (2019) Data quality evaluation of the dental fluorosis clinical assessment data from the National Health and Nutrition Examination Survey, 1999-2004 and 2011-2016Vital and Health Statistics, Series 2 Data evaulation and methods research (183) 1-24."},{"issue":"5","key":"b6","series-title":"European Journal of Oral Sciences","first-page":"357","article-title":"The ultrastructure of fluorosed human dental enamel","volume":"82","author":"Fejerskov\n              O","year":"1974","unstructured":"Fejerskov\n              O\n            , JohnsonN, & SilverstoneL (1974) The ultrastructure of fluorosed human dental enamelEuropean Journal of Oral Sciences82(5) 357-372."},{"key":"b7","series-title":"Journal of Dental Research","first-page":"714","article-title":"Differential diagnosis of dental fluorosis","volume":"69","author":"Cutress\n              T","year":"1990","unstructured":"Cutress\n              T\n             & SucklingG (1990) Differential diagnosis of dental fluorosisJournal of Dental Research69(2_suppl) 714-720."},{"key":"b8","series-title":"Biological Trace Element Research","first-page":"1","article-title":"Dental fluorosis: The risk of misdiagnosis\u2014A review","author":"Revelo-Mej\u00eda\n              IA","year":"2020","unstructured":"Revelo-Mej\u00eda\n              IA\n            , HardissonA, RubioC, Guti\u00e9rrez\u00c1J, & PazS (2020) Dental fluorosis: The risk of misdiagnosis\u2014A reviewBiological Trace Element Research1-9."},{"issue":"6","key":"b9","series-title":"Community Dentistry and Oral Epidemiology","first-page":"315","article-title":"Clinical appearance of dental fluorosis in permanent teeth in relation to histologic changes","volume":"6","author":"Thylstrup\n              A","year":"1978","unstructured":"Thylstrup\n              A\n             & FejerskovO (1978) Clinical appearance of dental fluorosis in permanent teeth in relation to histologic changesCommunity Dentistry and Oral Epidemiology6(6) 315-328."},{"issue":"1","key":"b10","series-title":"Caries Research","first-page":"3","article-title":"In vivo repeatability and reproducibility of the quantitative light-induced fluorescence method","volume":"36","author":"Tran\u00e6us\n              S","year":"2002","unstructured":"Tran\u00e6us\n              S\n            , ShiX-Q, LindgrenL-E, Trolls\u00e5sK, & AngmarM\u00e5nssonB (2002) In vivo repeatability and reproducibility of the quantitative light-induced fluorescence methodCaries Research36(1) 3-9."},{"issue":"6","key":"b11","series-title":"Caries Research","first-page":"464","article-title":"Comparative study to quantify demineralized enamel in deciduous and permanent teeth using laser- and light-induced fluorescence techniques","volume":"35","author":"Ando\n              M","year":"2001","unstructured":"Ando\n              M\n            , Van Der VeenMH, SchemehornBR, & StookeyGK (2001) Comparative study to quantify demineralized enamel in deciduous and permanent teeth using laser- and light-induced fluorescence techniquesCaries Research35(6) 464-470."},{"key":"b12","series-title":"Community Dentistry and Oral Epidemiology","first-page":"19","article-title":"A standardized photographic method for evaluating enamel opacities including fluorosis","volume":"32","author":"Cochran\n              JA","year":"2004","unstructured":"Cochran\n              JA\n            , KetleyCE, SanchesL, Mamai-HomataE, OilaAM, \u00c1rnad\u00f3ttirIB, Van LoverenC, WheltonHP, & O\u2019MullaneDM (2004) A standardized photographic method for evaluating enamel opacities including fluorosisCommunity Dentistry and Oral Epidemiology3219-27."},{"issue":"3","key":"b13","series-title":"Community Dentistry and Oral Epidemiology","first-page":"210","article-title":"Effect of fluoridated salt intake in infancy: A blind caries and fluorosis study in 8th grade Hungarian pupils","volume":"27","author":"Stephen\n              KW","year":"1999","unstructured":"Stephen\n              KW\n            , MacphersonLM, GorzoI, & GilmourWH (1999) Effect of fluoridated salt intake in infancy: A blind caries and fluorosis study in 8th grade Hungarian pupilsCommunity Dentistry and Oral Epidemiology27(3) 210-215."},{"key":"b14","article-title":"Ask the experts: How does a modern practice use intraoral cameras?","author":"Austin\n              J","year":"2020","unstructured":"Austin\n              J\n             & GividenSL (2020) Ask the experts: How does a modern practice use intraoral cameras? Retrieved online 04\/04\/2021, 2021 from: https:\/\/www.dentaleconomics.com\/practice\/systems\/article\/14183325\/ask-the-experts-how-does-a-modern-practice-use-intraoral-cameras."},{"issue":"1","key":"b15","series-title":"International Dental Journal","first-page":"3","article-title":"The assessment of an intra-oral video camera as an aid to occlusal caries detection","volume":"53","author":"Forgie\n              A","year":"2003","unstructured":"Forgie\n              A\n            , PineC, & PittsN (2003) The assessment of an intra-oral video camera as an aid to occlusal caries detectionInternational Dental Journal53(1) 3-6."},{"key":"b16","series-title":"Clinical, Cosmetic and Investigational Dentistry","first-page":"267","article-title":"Clinical applications of intraoral camera to increase patient compliance-Current perspectives","volume":"11","author":"Pentapati\n              K-C","year":"2019","unstructured":"Pentapati\n              K-C\n             & SiddiqH (2019) Clinical applications of intraoral camera to increase patient compliance-Current perspectivesClinical, Cosmetic and Investigational Dentistry11267-278."},{"key":"b17","article-title":"Health Promotion and Disease Prevention Research Centers: Special Interest Project Competitive Supplements (SIPS) Centers for Disease Control and Prevention USA","author":"Department of Health and Human Services","year":"2017","unstructured":"Department of Health and Human Services\n           (2017) Health Promotion and Disease Prevention Research Centers: Special Interest Project Competitive Supplements (SIPS) Centers for Disease Control and Prevention USA, Atlanta, GA."},{"issue":"2","key":"b18","series-title":"Folia medica","first-page":"43","article-title":"Aesthetic perception of dental fluorosis-Opinions of dentists and non-specialists","volume":"52","author":"Kukleva\n              M","year":"2010","unstructured":"Kukleva\n              M\n            , KondevaV, IshevaA, PetrovaS, & RimalovskaS (2010) Aesthetic perception of dental fluorosis-Opinions of dentists and non-specialistsFolia medica52(2) 43-48."},{"issue":"1","key":"b19","series-title":"Community Dentistry and Oral Epidemiology","first-page":"e41","article-title":"International Caries Detection and Assessment System (ICDAS) and its International Caries Classification and Management System (ICCMS)\u2013Methods for staging of the caries process and enabling dentists to manage caries","volume":"41","author":"Pitts\n              N","year":"2013","unstructured":"Pitts\n              N\n            , EkstrandK, & FoundationI (2013) International Caries Detection and Assessment System (ICDAS) and its International Caries Classification and Management System (ICCMS)\u2013Methods for staging of the caries process and enabling dentists to manage cariesCommunity Dentistry and Oral Epidemiology41(1) e41-e52."},{"key":"b20","series-title":"Journal of Dentistry","first-page":"42","article-title":"Relationship between enamel fluorosis severity and fluoride content","volume":"46","author":"Martinez-Mier\n              EA","year":"2016","unstructured":"Martinez-Mier\n              EA\n            , ShoneDB, BuckleyCM, AndoM, LippertF, & Soto-RojasAE (2016) Relationship between enamel fluorosis severity and fluoride contentJournal of Dentistry4642-46."},{"issue":"1","key":"b21","series-title":"Biometrics","first-page":"159","article-title":"The measurement of observer agreement for categorical data","volume":"33","author":"Landis\n              JR","year":"1977","unstructured":"Landis\n              JR\n             & KochGG (1977) The measurement of observer agreement for categorical dataBiometrics33(1) 159-174."},{"issue":"1","key":"b22","series-title":"Caries Research","first-page":"2","article-title":"A new method for in vivo quantification of changes in initial enamel caries with laser fluorescence","volume":"29","author":"De Jong\n              EdJ","year":"1995","unstructured":"De Jong\n              EdJ\n            , Sundstr\u00f6mF, WesterlingH, TranaeusS, Ten BoschJ, & Angmar-M\u00e5nssonB (1995) A new method for in vivo quantification of changes in initial enamel caries with laser fluorescenceCaries Research29(1) 2-7."},{"key":"b23","series-title":"Monographs in Oral Science","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000061639","article-title":"Application of quantitative light-induced fluorescence for assessing early caries lesions","volume":"17","author":"Van Der Veen\n              M","year":"2000","unstructured":"Van Der Veen\n              M\n            , & de JongEdJ (2000) Application of quantitative light-induced fluorescence for assessing early caries lesionsMonographs in Oral Science17144-162."},{"issue":"5","key":"b24","series-title":"Caries Research","first-page":"515","article-title":"In vitro validation of quantitative light-induced fluorescence for the diagnosis of enamel fluorosis in permanent teeth","volume":"51","author":"Cuevas-Espinosa\n              DM","year":"2017","unstructured":"Cuevas-Espinosa\n              DM\n            , Martinez-MierE, AndoM, CastiblancoG, Cort\u00e9sF, Rincon-BermudezCM, & MartignonS (2017) In vitro validation of quantitative light-induced fluorescence for the diagnosis of enamel fluorosis in permanent teethCaries Research51(5) 515-526."},{"key":"b25","series-title":"Mastering dental photography","author":"Bengel\n              W","year":"2002","unstructured":"Bengel\n              W\n            \n           (2002) Mastering dental photographyQuintessence Publishing Carol Stream, IL, USA."},{"issue":"10","key":"b26","series-title":"Journal of Dental Research","first-page":"877","article-title":"The impact of fluoride on ameloblasts and the mechanisms of enamel fluorosis","volume":"88","author":"Bronckers\n              A","year":"2009","unstructured":"Bronckers\n              A\n            , LyaruuD, & DenBestenP (2009) The impact of fluoride on ameloblasts and the mechanisms of enamel fluorosisJournal of Dental Research88(10) 877-893."},{"issue":"6","key":"b27","series-title":"American Journal of Public Health and the Nations Health","first-page":"567","article-title":"Some epidemiological aspects of chronic endemic dental fluorosis","volume":"26","author":"Dean\n              HT","year":"1936","unstructured":"Dean\n              HT\n             & ElvoveE (1936) Some epidemiological aspects of chronic endemic dental fluorosisAmerican Journal of Public Health and the Nations Health26(6) 567-575."},{"issue":"1","key":"b28","series-title":"Advances in Dental Research","first-page":"105","article-title":"Dental fluorosis: Its use as a biomarker","volume":"8","author":"Den Besten\n              P","year":"1994","unstructured":"Den Besten\n              P\n            \n           (1994) Dental fluorosis: Its use as a biomarkerAdvances in Dental Research8(1) 105-110."},{"issue":"1","key":"b29","series-title":"BMC Public Health","first-page":"1","article-title":"Quantitative light fluorescence (QLF) and polarized white light (PWL) assessments of dental fluorosis in an epidemiological setting","volume":"12","author":"Pretty\n              IA","year":"2012","unstructured":"Pretty\n              IA\n            , McGradyM, ZakianC, EllwoodRP, TaylorA, SharifMO, IafollaT, Martinez-MierEA, SrisilapananP, & KorwanichN (2012) Quantitative light fluorescence (QLF) and polarized white light (PWL) assessments of dental fluorosis in an epidemiological settingBMC Public Health12(1) 1-10"}],"container-title":["Operative Dentistry"],"original-title":[],"link":[{"URL":"https:\/\/operative-dentistry.kglmeridian.com\/view\/journals\/odnt\/50\/3\/article-p311.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/meridian.allenpress.com\/operative-dentistry\/article-pdf\/50\/3\/311\/3528593\/i1559-2863-50-3-311.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/operative-dentistry.kglmeridian.com\/downloadpdf\/journals\/odnt\/50\/3\/article-p311.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/operative-dentistry.kglmeridian.com\/downloadpdf\/journals\/odnt\/50\/3\/article-p311.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:50:23Z","timestamp":1758934223000},"score":1,"resource":{"primary":{"URL":"https:\/\/operative-dentistry.kglmeridian.com\/view\/journals\/odnt\/50\/3\/article-p311.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":29,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.2341\/24-137-c","relation":{},"ISSN":["1559-2863","0361-7734"],"issn-type":[{"type":"electronic","value":"1559-2863"},{"type":"print","value":"0361-7734"}],"subject":[],"published":{"date-parts":[[2025,5]]}}}