{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:41:54Z","timestamp":1763746914803},"reference-count":26,"publisher":"American Dental Society of Anesthesiology (ADSA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>Benzodiazepines in intravenous sedation are useful, owing to their outstanding amnesic effect when used for oral surgery as well as dental treatments on patients with intellectual disability or dental phobia. However, compared with propofol, the effect of benzodiazepine lasts longer and may impede discharge, especially when it is administered orally because of fear of injections. Although flumazenil antagonizes the effects of benzodiazepine quickly, its effect on the equilibrium function (EF) has never been tested. Since EF is more objective than other tests, the purpose of this study is to assess the sedation level and EF using a computerized static posturographic platform. The collection of control values was followed by the injection of 0.075 mg\/kg of midazolam. Thirty minutes later, 0.5 mg or 1.0 mg of flumazenil was administered, and the sedation level and EF were measured until 150 minutes after flumazenil administration. Flumazenil antagonized sedation, and there was no apparent resedation; however, it failed to antagonize the disturbance in EF. This finding may be due to differences in the difficulty of assessing the sedation level and performing the EF test, and a greater amount of flumazenil may effectively antagonize the disturbance in EF.<\/jats:p>","DOI":"10.2344\/0003-3006-55.3.73","type":"journal-article","created":{"date-parts":[[2010,6,11]],"date-time":"2010-06-11T19:07:33Z","timestamp":1276283253000},"page":"73-77","source":"Crossref","is-referenced-by-count":7,"title":["Effect of Flumazenil on Disturbance of Equilibrium Function Induced by Midazolam"],"prefix":"10.2344","volume":"55","author":[{"given":"S.","family":"Maeda","sequence":"first","affiliation":[{"name":"Department of Dental Anesthesiology, Okayama University Dental Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Miyawaki","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Okayama University Dental Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Okayama University Dental Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Shimada","sequence":"additional","affiliation":[{"name":"Orofacial Pain Management, Department of Oral Restitution, Graduate School, Tokyo Medical and Dental University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1191","reference":[{"key":"i0003-3006-55-3-73-Dionne1","series-title":"J Am Dent Assoc","first-page":"740","article-title":"Comparing efficacy and safety of four intravenous sedation regimens in dental outpatients.","volume":"132","author":"Dionne, R. A.","year":"2001","unstructured":"Dionne, R. A., J. A.Yagiela, P. A.Moore, A.Gonty, J.Zuniga, and O. R.Beirne. Comparing efficacy and safety of four intravenous sedation regimens in dental outpatients.J Am Dent Assoc2001. 132:740\u2013751."},{"key":"i0003-3006-55-3-73-Miyawaki1","series-title":"J Intellect Disabil Res","first-page":"764","article-title":"Intravenous sedation for dental patients with intellectual disability.","volume":"48","author":"Miyawaki, T.","year":"2004","unstructured":"Miyawaki, T., A.Kohjitani, S.Maeda, et al. Intravenous sedation for dental patients with intellectual disability.J Intellect Disabil Res2004. 48:764\u2013768."},{"key":"i0003-3006-55-3-73-Korttila1","series-title":"J Dent Res","first-page":"848","article-title":"Clinical effectiveness and untoward effects of new agents and techniques used in intravenous sedation.","volume":"63","author":"Korttila, K.","year":"1984","unstructured":"Korttila, K.\n          \n          Clinical effectiveness and untoward effects of new agents and techniques used in intravenous sedation.\n          J Dent Res\n          1984. 63:848\u2013852."},{"key":"i0003-3006-55-3-73-Gupta1","series-title":"Br J Anaesth","first-page":"667","article-title":"Computerized dynamic posturography: a new method for the evaluation of postural stability following anaesthesia.","volume":"66","author":"Gupta, A.","year":"1991","unstructured":"Gupta, A., T.Ledin, L. E.Larsen, C.Lennmarken, and L. M.Odkvist. Computerized dynamic posturography: a new method for the evaluation of postural stability following anaesthesia.Br J Anaesth1991. 66:667\u2013672."},{"key":"i0003-3006-55-3-73-Ledin1","series-title":"Acta Otolaryngol","first-page":"245","article-title":"Randomized perturbed posturography: methodology and effects of midazolam sedation.","volume":"113","author":"Ledin, T.","year":"1993","unstructured":"Ledin, T., A.Gupta, L. E.Larsen, and L. M.Odkvist. Randomized perturbed posturography: methodology and effects of midazolam sedation.Acta Otolaryngol1993. 113:245\u2013248."},{"key":"i0003-3006-55-3-73-Korttila2","series-title":"Anesthesiology","first-page":"625","article-title":"Evaluation of instrumented force platform as a test to measure residual effects of anesthetics.","volume":"55","author":"Korttila, K.","year":"1981","unstructured":"Korttila, K., M. M.Ghoneim, L.Jacobs, and R. S.Lakes. Evaluation of instrumented force platform as a test to measure residual effects of anesthetics.Anesthesiology1981. 55:625\u2013630."},{"key":"i0003-3006-55-3-73-Hunkeler1","series-title":"Nature","first-page":"514","article-title":"Selective antagonists of benzodiazepines.","volume":"290","author":"Hunkeler, W.","year":"1981","unstructured":"Hunkeler, W., H.Mohler, L.Pieri, et al. Selective antagonists of benzodiazepines.Nature1981. 290:514\u2013516."},{"key":"i0003-3006-55-3-73-Mohler1","series-title":"Nature","first-page":"763","article-title":"Agonist and antagonist benzodiazepine receptor interaction in vitro.","volume":"294","author":"Mohler, H.","year":"1981","unstructured":"Mohler, H. and J. G.Richards. Agonist and antagonist benzodiazepine receptor interaction in vitro.Nature1981. 294:763\u2013765."},{"key":"i0003-3006-55-3-73-Lauven1","series-title":"Anesthesiology","first-page":"61","article-title":"The effects of a benzodiazepine antagonist Ro 15-1788 in the presence of stable concentrations of midazolam.","volume":"63","author":"Lauven, P. M.","year":"1985","unstructured":"Lauven, P. M., H.Schwilden, H.Stoeckel, and D. J.Greenblatt. The effects of a benzodiazepine antagonist Ro 15-1788 in the presence of stable concentrations of midazolam.Anesthesiology1985. 63:61\u201364."},{"key":"i0003-3006-55-3-73-Short1","series-title":"Acta Anaesthesiol Scand","first-page":"350","article-title":"Midazolam and flumazenil pharmacokinetics and pharmacodynamics following simultaneous administration to human volunteers.","volume":"38","author":"Short, T. G.","year":"1994","unstructured":"Short, T. G., K. K.Young, P.Tan, Y. H.Tam, T.Gin, and T. E.Oh. Midazolam and flumazenil pharmacokinetics and pharmacodynamics following simultaneous administration to human volunteers.Acta Anaesthesiol Scand1994. 38:350\u2013356."},{"key":"i0003-3006-55-3-73-Ghouri1","series-title":"Anesthesiology","first-page":"333","article-title":"Effect of flumazenil on recovery after midazolam and propofol sedation.","volume":"81","author":"Ghouri, A. F.","year":"1994","unstructured":"Ghouri, A. F., M. A.Ruiz, and P. F.White. Effect of flumazenil on recovery after midazolam and propofol sedation.Anesthesiology1994. 81:333\u2013339."},{"key":"i0003-3006-55-3-73-Klausen1","series-title":"Acta Anaesthesiol Scand","first-page":"409","article-title":"Flumazenil in total intravenous anaesthesia using midazolam and fentanyl.","volume":"32","author":"Klausen, N. O.","year":"1988","unstructured":"Klausen, N. O., O.Juhl, J.Sorensen, A. H.Ferguson, and P. B.Neumann. Flumazenil in total intravenous anaesthesia using midazolam and fentanyl.Acta Anaesthesiol Scand1988. 32:409\u2013412."},{"key":"i0003-3006-55-3-73-Luger1","series-title":"Br J Anaesth","first-page":"53","article-title":"Additional subcutaneous administration of flumazenil does not shorten recovery time after midazolam.","volume":"64","author":"Luger, T. J.","year":"1990","unstructured":"Luger, T. J., R. F.Morawetz, and G.Mitterschiffthaler. Additional subcutaneous administration of flumazenil does not shorten recovery time after midazolam.Br J Anaesth1990. 64:53\u201358."},{"key":"i0003-3006-55-3-73-Jensen1","series-title":"Acta Anaesthesiol Scand","first-page":"26","article-title":"Flumazenil used for antagonizing the central effects of midazolam and diazepam in outpatients.","volume":"33","author":"Jensen, S.","year":"1989","unstructured":"Jensen, S., L.Knudsen, L.Kirkegaard, A.Kruse, and E. B.Knudsen. Flumazenil used for antagonizing the central effects of midazolam and diazepam in outpatients.Acta Anaesthesiol Scand1989. 33:26\u201328."},{"key":"i0003-3006-55-3-73-Dodgson1","series-title":"Acta Anaesthesiol Scand","first-page":"629","article-title":"Antagonism of diazepam-induced sedative effects by Ro15-1788 in patients after surgery under lumbar epidural block. A double-blind placebo-controlled investigation of efficacy and safety.","volume":"31","author":"Dodgson, M. S.","year":"1987","unstructured":"Dodgson, M. S., B.Skeie, S.Emhjellen, E.Wickstrom, and P. A.Steen. Antagonism of diazepam-induced sedative effects by Ro15-1788 in patients after surgery under lumbar epidural block. A double-blind placebo-controlled investigation of efficacy and safety.Acta Anaesthesiol Scand1987. 31:629\u2013633."},{"key":"i0003-3006-55-3-73-Andrews1","series-title":"Anaesthesia","first-page":"445","article-title":"Flumazenil in the outpatient. A study following midazolam as sedation for upper gastrointestinal endoscopy.","volume":"45","author":"Andrews, P. J.","year":"1990","unstructured":"Andrews, P. J., D. J.Wright, and M. C.Lamont. Flumazenil in the outpatient. A study following midazolam as sedation for upper gastrointestinal endoscopy.Anaesthesia1990. 45:445\u2013448."},{"key":"i0003-3006-55-3-73-Sanders1","series-title":"Br J Anaesth","first-page":"445","article-title":"Reversal of benzodiazepine sedation with the antagonist flumazenil.","volume":"66","author":"Sanders, L. D.","year":"1991","unstructured":"Sanders, L. D., S. E.Piggott, P. A.Isaac, et al. Reversal of benzodiazepine sedation with the antagonist flumazenil.Br J Anaesth1991. 66:445\u2013453."},{"key":"i0003-3006-55-3-73-Pratila1","series-title":"J Clin Anesth","first-page":"268","article-title":"Propofol versus midazolam for monitored sedation: a comparison of intraoperative and recovery parameters.","volume":"5","author":"Pratila, M. G.","year":"1993","unstructured":"Pratila, M. G., M. E.Fischer, R.Alagesan, R. A.Reinsel, and D.Pratilas. Propofol versus midazolam for monitored sedation: a comparison of intraoperative and recovery parameters.J Clin Anesth1993. 5:268\u2013274."},{"key":"i0003-3006-55-3-73-Snyder1","series-title":"Am J Psychiatry","first-page":"662","article-title":"Brain mechanisms associated with therapeutic actions of benzodiazepines: focus on neurotransmitters.","volume":"134","author":"Snyder, S. H.","year":"1977","unstructured":"Snyder, S. H., S. J.Enna, and A. B.Young. Brain mechanisms associated with therapeutic actions of benzodiazepines: focus on neurotransmitters.Am J Psychiatry1977. 134:662\u2013665."},{"key":"i0003-3006-55-3-73-Young1","series-title":"Proc Natl Acad Sci U S A","first-page":"2246","article-title":"Interaction of benzodiazepines with central nervous glycine receptors: possible mechanism of action.","volume":"71","author":"Young, A. B.","year":"1974","unstructured":"Young, A. B., S. R.Zukin, and S. H.Snyder. Interaction of benzodiazepines with central nervous glycine receptors: possible mechanism of action.Proc Natl Acad Sci U S A1974. 71:2246\u20132250."},{"key":"i0003-3006-55-3-73-Richter1","series-title":"Anesthesiology","first-page":"66","article-title":"Current theories about the mechanisms of benzodiazepines and neuroleptic drugs.","volume":"54","author":"Richter, J. J.","year":"1981","unstructured":"Richter, J. J.\n          \n          Current theories about the mechanisms of benzodiazepines and neuroleptic drugs.\n          Anesthesiology\n          1981. 54:66\u201372."},{"key":"i0003-3006-55-3-73-Sanders2","series-title":"Paediatr Anaesth","first-page":"369","article-title":"Flumazenil reverses a paradoxical reaction to intravenous midazolam in a child with uneventful prior exposure to midazolam.","volume":"13","author":"Sanders, J. C.","year":"2003","unstructured":"Sanders, J. C.\n          \n          Flumazenil reverses a paradoxical reaction to intravenous midazolam in a child with uneventful prior exposure to midazolam.\n          Paediatr Anaesth\n          2003. 13:369\u2013370."},{"key":"i0003-3006-55-3-73-Schofield1","series-title":"Nature","first-page":"221","article-title":"Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family.","volume":"328","author":"Schofield, P. R.","year":"1987","unstructured":"Schofield, P. R., M. G.Darlison, N.Fujita, et al. Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family.Nature1987. 328:221\u2013227."},{"key":"i0003-3006-55-3-73-Braestrup1","series-title":"Proc Natl Acad Sci U S A","first-page":"3805","article-title":"Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding.","volume":"74","author":"Braestrup, C.","year":"1977","unstructured":"Braestrup, C. and R. F.Squires. Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding.Proc Natl Acad Sci U S A1977. 74:3805\u20133809."},{"key":"i0003-3006-55-3-73-Reves1","series-title":"Anesthesiology","first-page":"310","article-title":"Midazolam: pharmacology and uses.","volume":"62","author":"Reves, J. G.","year":"1985","unstructured":"Reves, J. G., R. J.Fragen, H. R.Vinik, and D. J.Greenblatt. Midazolam: pharmacology and uses.Anesthesiology1985. 62:310\u2013324."},{"key":"i0003-3006-55-3-73-Mak1","series-title":"J Pharmacol Exp Ther","first-page":"880","article-title":"Peripheral type benzodiazepine receptors in human and guinea pig lung: characterization and autoradiographic mapping.","volume":"252","author":"Mak, J. C.","year":"1990","unstructured":"Mak, J. C. and P. J.Barnes. Peripheral type benzodiazepine receptors in human and guinea pig lung: characterization and autoradiographic mapping.J Pharmacol Exp Ther1990. 252:880\u2013885."}],"container-title":["Anesthesia Progress"],"original-title":[],"link":[{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/55\/3\/article-p73.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/anesthesia-progress\/article-pdf\/55\/3\/73\/2100549\/0003-3006-55_3_73.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/55\/3\/article-p73.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/55\/3\/article-p73.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T12:19:32Z","timestamp":1728303572000},"score":1,"resource":{"primary":{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/55\/3\/article-p73.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":26,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.2344\/0003-3006-55.3.73","relation":{},"ISSN":["0003-3006","1878-7177"],"issn-type":[{"type":"print","value":"0003-3006"},{"type":"electronic","value":"1878-7177"}],"subject":[],"published":{"date-parts":[[2008]]}}}